School of Medicine
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Maureen Lyles D'Ambrogio Professor in the School of Medicine
Current Research and Scholarly InterestsOur long term interest is to have a better understanding of the natural antithrombotic pathways and the pathophysiology of vascular thrombosis. We have focused on thrombin, the key enzyme in the blood clotting cascade.Our goal is to develop new antithrombotic agents and devise new diagnostic tests for vascular thrombotic disorders.
Professor of Medicine (Hematology) at the Santa Clara Valley Medical Center, Emeritus
Current Research and Scholarly InterestsLow molecular-weight heparins Clinical trials with anti-thrombotics Clinical trials in patients with leukemia, breast cancer and myeloma Medical education.
Associate Professor of Medicine (Hematology)
Current Research and Scholarly Interests1) Design of phase I/II trials for the treatment of Multiple Myeloma and Amyloidosis
2) Conduct of clinical trials to improve the treatment of patients with acute lymphoblastic leukemia (ALL)
3) Outcomes research using clinical databases for patients with Multiple Myeloma and Amyloidosis
4) Characterization of the molecular mechanism of MLL-induced acute leukemia
Postdoctoral Scholar, Hematology
BioI am currently working on several projects to understand the control of gastrointestinal and cancer stem cell biology, especially how critical intrinsic genetic mutations and extrinsic extracellular components within the microenvironment influence cell behaviors. Stem cells of the gastrointestinal tract give rise to the surface lining of the epithelium, and must continuously produce new cells to replace those shed into the lumen throughout the lifespan. When mutations accumulate in these stem cells, they can grow uncontrollably into benign polyps or malignant tumors. In Dr. Calvin Kuo’s laboratory, I have used transgenic mice and primary human organoids as the models. Human organoids provide a robust primary culture system to recapitulate 3D structure and multilineage differentiation, which represents an underutilized method for the study of stem cell and cancer biology (Lo et al, Nature Cancer 2020). I have focused my efforts on establishing next generation CRISPR/Cas9 genome editing tools in primary human organoids, and applying this powerful system to gain insight into how different signaling pathways can contribute to gastrointestinal stem cell activity and tumorigenesis (Lo et al, Cancer Discovery 2021).
Sydney X. Lu
Assistant Professor of Medicine (Hematology)
BioSydney Lu is a hematologist and medical oncologist in the Division of Hematology, Department of Medicine, studying novel therapeutics for challenging cancers and immune disorders.
Sydney's research career started with graduate studies in the laboratory of Dr. Marcel van den Brink at Memorial Sloan Kettering Cancer Center (MSKCC) studying the biology of pathologic donor T cells during graft-versus-host-disease and beneficial T cells mediating graft-versus-tumor effects after allogeneic bone marrow transplant, as well as the role of the thymus in regenerating healthy and protective donor-derived T cells post-transplant.
The direct relevance of these cellular therapies and their immediate translational applicability to patients inspired him to attend medical school at Stanford and further training in hematology and medical oncology at Memorial Sloan Kettering. There, as a fellow and junior faculty member, he studied disordered RNA splicing in cancer in the laboratory of Dr. Omar Abdel-Wahab, with the goal of developing novel drugs targeting RNA splicing. This work has led to observations that targeted degradation of the RNA binding protein RBM39 may be a feasible therapeutic for the treatment of myeloid cancers bearing RNA splicing factor mutations and that pharmacologic RNA splicing inhibition can generate MHC I-presented peptide neoantigens which are exploitable for immunotherapy in model systems.
Sydney's laboratory is broadly interested in studying RNA processing and splicing in the contexts of:
1) normal and pathologic immunity and immunotherapy
2) cancer biology
3) normal and malignant hematopoiesis