School of Medicine
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Aluya Oseghale, PhD
Postdoctoral Scholar, Stem Cell Transplantation
BioMy primary goal is to develop an independent research career in hematology. As an African from a family background afflicted by hereditary hematologic disorders, I have longed to be part of research efforts to develop better treatments for blood diseases. My doctoral research focused on sickle cell disease where I conducted a preclinical investigation of a novel derivative of butyrate as a drug candidate for ameliorating the complications of the illness (Oseghale AR et al. Blood Cells Mol Dis. 2019 Jul 9;79:102345). My current focus as a postdoctoral scholar, in the Porteus laboratory, is to use CRISPR/Cas9 for genomic modification of human primary cells for curative therapeutic applications. A major aim of my project is to develop an automated closed system for the manufacturing of CRISPR/Cas9-engineered chimeric antigen receptor-expressing (CAR) T cells.