School of Medicine
Showing 241-250 of 251 Results
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Elisabetta Viani Puglisi
Associate Professor (Research) of Structural Biology
Current Research and Scholarly InterestsViral infections and subsequent host response depend on multiple RNA-protein interaction. My research focuses on the structural and functional characterization of RNA-protein complexes involved in viral infection. Current research aims to understand how the Human Immunodeficiency Virus (HIV) initiates its replication upon host infection. We use NMR spectroscopy and x-ray crystallography to study the structure of the initiation complex, formed by a host tRNA and HIV genomic RNA, coupled with biochemical and biophysical methods to understand functional properties. The goal of this research is to gain a molecular view of HIV replication initiation, and use this information to develop new therapeutic approaches to combat HIV.
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Joseph (Jody) Puglisi
Jauch Professor and Professor of Structural Biology
Current Research and Scholarly InterestsThe Puglisi group investigates the role of RNA in cellular processes and disease. We investigate dynamics using single-molecule approaches. Our goal is a unified picture of structure, dynamics and function. We are currently focused on the mechanism and regulation of translation, and the role of RNA in viral infections. A long-term goal is to target processes involving RNA with novel therapeutic strategies.
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Benjamin Pulli, MD
Clinical Assistant Professor, Radiology
Clinical Assistant Professor (By courtesy), NeurosurgeryBioDr. Pulli is a dual fellowship trained diagnostic and interventional neuroradiologist with a focus on vascular disorders of the brain, head, neck, and spine. He is a clinical assistant professor in the Department of Radiology, Neuroradiology Division.
Having grown up in Austria, Dr. Pulli moved to the US after completing medical school in Innsbruck, Austria. He completed post-doctoral research training in stroke imaging in the Division of Neuroradiology at the Massachusetts General Hospital, as well as in experimental molecular imaging techniques of neuroinflammatory disorders at the Center for Systems Biology of Massachusetts General Hospital and Harvard Medical School.
He completed residency training in Radiology and fellowship training in Diagnostic Neuroradiology at the Massachusetts General Hospital in Boston. He then completed a second fellowship in interventional neuroradiology/neurointerventional surgery at Stanford University School of Medicine.
After having graduated from fellowship, Dr. Pulli then spent more than a year practicing Interventional Neuroradiology at Pacific Neuroscience Institute in Los Angeles. He employs state-of-the-art minimally invasive endovascular and percutaneous surgical techniques to treat patients with brain aneurysms, arteriovenous malformations, dural arteriovenous fistulas, carotid artery stenosis, acute stroke, chronic subdural hematoma, idiopathic intracranial hypertension, vascular tumors, and chronic back pain.
His research focuses on advanced imaging techniques for acute ischemic stroke and other neurovascular diseases. He has authored more than 40 peer-reviewed publications and received scientific grants from institutions such as the Radiological Society of North America and the Ernst Schering Foundation. In addition, he has made invited presentations to his peers at meetings of organizations such as the American Society of Neuroradiology, Radiological Society of North American, European Congress of Radiology, and Western Neuroradiological Society.
He is a member of the Society of Neurointerventional Surgery. -
Stephanie Pun, MD
Clinical Associate Professor, Orthopaedic Surgery
Current Research and Scholarly InterestsDr. Pun specializes in the treatment of complex hip disorders with surgical hip preservation options for children, adolescents, and adults. Her goal is to enhance hip function in active individuals and to prevent the early development of hip osteoarthritis.
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Patrick Lee Purdon
Professor of Anesthesiology, Perioperative and Pain Medicine (Department Research) and, by courtesy, of Bioengineering
BioMy research integrates neuroimaging, biomedical signal processing, and the systems neuroscience of general anesthesia and sedation.
My group conducts human studies of anesthesia-induced unconsciousness, using a variety of techniques including multimodal neuroimaging, high-density EEG, and invasive neurophysiological recordings used to diagnose medically refractory epilepsy. We also develop novel methods in neuroimaging and biomedical signal processing to support these studies, as well as methods for monitoring level of consciousness under general anesthesia using EEG.
