School of Medicine
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Atif Saleem
Clinical Assistant Professor (Affiliated), Pathology Clinical
Staff, Pathology Operations supported expensesBioDr. Atif Saleem completed his residency training in Anatomic and Clinical Pathology, followed by fellowships in Hematopathology and Dermatopathology at Stanford. He is board certified in both Anatomic Pathology and Clinical Pathology, Hematopathology, and Dermatopathology. His interests include virus-associated neoplasms, medical education, and global health.
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Darren Salmi
Clinical Assistant Professor, Pathology
Current Research and Scholarly InterestsCardiovascular pathology, congenital heart disease, autopsy, medical education
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Ansuman Satpathy
Assistant Professor of Pathology
Current Research and Scholarly InterestsOur lab works at the interface of immunology, cancer biology, and genomics to study cellular and molecular mechanisms of the immune response to cancer. In particular, we are leveraging high-throughput genomic technologies to understand the dynamics of the tumor-specific T cell response to cancer antigens and immunotherapies (checkpoint blockade, CAR-T cells, and others). We are also interested in understanding the impact of immuno-editing on the heterogeneity and clonal evolution of cancer.
We previously developed genome sequencing technologies that enable epigenetic studies in primary human immune cells from patients: 1) 3D enhancer-promoter interaction profiling (Nat Genet, 2017), 2) paired epigenome and T cell receptor (TCR) profiling in single cells (Nat Med, 2018), 3) paired epigenome and CRISPR profiling in single cells (Cell, 2019), and high-throughput single-cell ATAC-seq in droplets (Nature Biotech, 2019). We used these tools to study fundamental principles of the T cell response to cancer immunotherapy (PD-1 blockade) directly in cancer patient samples (Nature Biotech, 2019; Nat Med, 2019).
