School of Medicine
Showing 1-10 of 528 Results
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Raya Saab
Lindhard Family Professor of Pediatric Cancer Biology
BioOur laboratory focuses on investigating molecular mechanisms of oncogene-induced tumorigenesis and tumor suppressor pathways, and oncogenic signaling in the pediatric solid tumor rhabdomyosarcoma. Our earlier work identified the tumor suppressors p53 and p18Ink4c as inhibitors of Cyclin D1-driven tumorigenesis in a pineoblastoma model, through senescence induction, and highlighted distinct roles for the the RB and p53 pathways in induction and maintenance of oncogene-induced senescence. We also identified CDK2 as a potential target for inducing senescence in premalignant lesions to inhibit tumor progression.
Our current focus is on studying oncogenic signaling and tumor suppression in the childhood tumor rhabdomyosarcoma, to identify key mediators of invasion and metastasis, which is the most common cause of treatment failure clinically. We use preclinical in vitro and in vivo models, including murine and human cell lines, and mouse models of disease.
We have recently uncovered a paracrine role for rhabdomyosarcoma-secreted exosomes in impacting biology of stromal cells. Rhabdomyosarcoma-derived exosomes carry specific miRNA cargo that imparts an invasive and migratory phenotype on normal recipient fibroblasts, and proteomic analysis revealed specific and unique pathways relevant to the two different molecular rhabdomyosarcoma subtypes that are driven by distinct oncogenic pathways. We identified that the driver oncogene in fusion-positive rhabdomyosarcoma, PAX3-FOXO1, modulates exosome cargo to promote invasion, migration, and angiogenic properties, and identified specific microRNA and protein cargo acting as effectors of PAX3-FOXO1 exosome-mediated signaling, including modulation of oxidative stress response and cell survival signaling.
Our ongoing work is focused on interrogating specific paracrine signaling pathways and molecular mechanisms of metastatic disease progression in rhabdomyosarcoma, for potential therapeutic targeting. -
Chiara Sabatti
Professor of Biomedical Data Science and of Statistics
Current Research and Scholarly InterestsStatistical models and reasoning are key to our understanding of the genetic basis of human traits. Modern high-throughput technology presents us with new opportunities and challenges. We develop statistical approaches for high dimensional data in the attempt of improving our understanding of the molecular basis of health related traits.
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Zahra Sadat-Hossieny, MD
Clinical Assistant Professor, Adult Neurology
BioZahra Sadat-Hossieny, MD, is a board-certified neurologist who completed her fellowship in clinical epilepsy at Stanford University Hospitals and Clinics. She finished her residency in neurology at the Ohio State University Wexner Medical Center. She obtained her medical degree and a certificate in global health from the George Washington University School of Medicine and Health Sciences.
She has extensive experience treating patients with epilepsy and currently provides care through the Comprehensive Epilepsy and Comprehensive Neurology Programs at Stanford Health Care. In addition to her clinical responsibilities, Dr. Sadat-Hossieny also teaches future generations of clinicians as an assistant professor at Stanford School of Medicine in the Department of Neurology, Epilepsy, and Comprehensive Neurology.
Dr. Sadat-Hossieny has authored several peer-reviewed journal articles and book chapters. She has presented her research orally and through posters at various conferences. During her fellowship at Stanford University Hospitals and Clinics, she used advanced diagnostic techniques including video-EEG monitoring, computerized brainwave mapping, diagnostic imaging, neuropsychiatric testing, and functional mapping to accurately diagnose epilepsy and conditions imitating epilepsy. She also gained expertise in the most advanced forms of epilepsy treatment including neuromodulation, epilepsy surgery and medications specific to epilepsy. Her research focused on the cognitive effects of anti-seizure medications on patients with epilepsy and their children. She has also published on the importance of nutrient supplementation on cognition in patients taking anti-seizure medications. Her collaborations include projects that assess and improve patients’ understanding of their own seizure types. -
Rebecca Saenz
Clinical Assistant Professor, Pediatrics - Immunology and Allergy
Current Research and Scholarly InterestsAllergy, Immunology, Bioengineering and Biodesign
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Samuel Ricardo Saenz
Clinical Assistant Professor, Psychiatry and Behavioral Sciences
BioDr. Sam Saenz was born in the Bay Area and received his bachelor’s degree in psychology from Stanford University. He completed his medical degree at UC Irvine’s Program in Medical Education for the Latino Community, and he also obtained a Master’s in Public Health from UC Berkeley. After serving as chief psychiatry resident during his psychiatry residency at Stanford, he completed a fellowship in public psychiatry at UC San Francisco. His professional interests include fostering the next generation of diverse mental health providers and community advocacy.
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Debra Safer
Professor of Psychiatry and Behavioral Sciences (General Psychiatry and Psychology-Adult)
Current Research and Scholarly InterestsPrimary research interests include the nature and treatment of eating disorders
(particularly bulimia nervosa and binge eating disorder), the development and treatment of obesity, and the development and treatment of problematic eating patterns in patients following bariatric surgery.
