School of Medicine
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Professor of Medicine (Gastroenterology and Hepatology)
Current Research and Scholarly InterestsOur laboratory has been focusing on the mechanism of liver fibrosis and the role of hepatocyte cell death in fibrogenic injury. We have demonstrated the intricate link between hepatocyte apoptosis, generation of apoptotic bodies and their efferocytosis by stellate cells triggering fibrogenic activation. Key to this was the activation of the NADPH oxidase NOX2 and production of reactive oxidative species inducing stellate cell transdifferentiation and collagen I transcription. We have expanded our work focusing on the role of non-phagocytic NOX4 in dysregulating insulin responses and precipitating ER and mitochondrial stress signaling in non-alcoholic steatohepatitis. We are particularly interested in clinical conditions that are linked to accelerated fibrosis such as during aging and T2DM. Our other major focus is on alcoholic hepatitis, and defining novel therapeutic targets based on sterile inflammatory pathways. Our ultimate goal is translation and developing new treatment approaches that reverse fibrosis and improve patient outcomes.
Clinical Professor, Medicine - Gastroenterology & Hepatology
Current Research and Scholarly InterestsMy primary research interest concerns factors involved in the pathogenesis of gastro-esophageal reflux disease and its complications, such as Barrett's esophagus and the role of diagnostic and therapeutic modalities in their management.