School of Medicine
Showing 1-8 of 8 Results
Laurens van de Wiel
Postdoctoral Scholar, Cardiovascular Medicine
BioLaurens van de Wiel is Dutch scientist from Berghem, The Netherlands. Laurens spent his undergrad in Software Development (BSc, Avans Hogeschool ‘s-Hertogenbosch) and Computing Science (MSc, Radboud University Nijmegen). Laurens continued his career at a start-up, where he created large-scale, real-time analytical software. Laurens continued on his academic trajectory at the Radboudumc in Nijmegen, where he started his PhD in bioinformatics.
During his PhD, Laurens integrated genetic data with protein 3D structures and protein domains. He utilized the skills he obtained before setting out on his academic trajectory; building large-scale, robust, reliable software. Exemplified by the MetaDome Web server (https://stuart.radboudumc.nl/metadome/). During his PhD, he developed novel methodologies for the interpretation of genetic variants of unknown clinical significance and, by integrating structural and evolutionary biology with genomics, Laurens identified 36 novel disease-gene associations for developmental disorders. These discoveries enabled diagnosis for over 500 families worldwide.
Laurens’ areas of expertise are (bioinformatic) software development, data integration of genetic variation with other omics, and his research aims are:
1.) Lessons long-learned in computer science aid computational biology
2.) Multi-omic data integration allows the impact measurement of genetic variation
3.) Diagnosing undiagnosed disorders will uncover novel insights into biology.
4.) International and multidisciplinary collaborations are key in diagnosing rare disorders.
At Stanford University, under guidance of Dr. Matthew Wheeler, he is conducting his postdoctoral studies in line with his research aims.
Postdoctoral Scholar, Infectious Diseases
BioMy research primarily focuses on clinical translational science of infectious diseases with an emphasis on tuberculosis and SARS-CoV-2. I leverage multiplex qPCR, whole genome sequencing and mass spectrometry-based technologies to develop novel diagnostics for pathogen detection and personalize TB treatment by pharmacogenomic analysis. In addition, I develop and test innovative approaches to study transmission of infectious diseases and evaluate control measures in congregate/community settings.
i)Development and validation of molecular viability assays for detection and quantification of novel SARS-CoV-2 virus in COVID-19 patients
ii)Development and validation of a novel aerosol capture tool for the detection of SARS-CoV-2 in exhaled breath from COVID-19 patients with mild and severe symptoms
iii)Development of a rapid pharmacogenomic assay to detect NAT2 polymorphisms and predict INH acetylation to guide dosing for tuberculosis treatment
iv)Detection of M. tuberculosis in the environment as a novel tool for identifying high-risk locations for tuberculosis transmission
v)Analyzing host serum biomarkers in latent and active Tuberculosis using ELISA assays in patients as a measure of disease severity.
Jorge Villalpando Salazar
Postdoctoral Medical Fellow, Pulmonary and Critical Care Medicine
BioMy areas of interest include pulmonary vascular disease and lung transplantation. I feel passionate about this field of medicine because it allows me to practice very well-rounded medicine and implement all the knowledge acquired since the beginning of my residency training.
As a lung transplant specialist, we follow our patients through this life changing journey and essentially become their primary care providers. I have the opportunity to practice hospital and pulmonary medicine in the wards managing end stage lung disease and other internal medicine pathologies. Lastly, we are a key component of the multidisciplinary team that takes care of the patient in the intensive care unit during the post operative period when our patients need us the most. The versatility of skill sets required to be a good lung transplant specialist keeps me on my toes and makes me love this profession.
My ultimate career goal is to become an academic lung transplant specialist and contribute to this rapidly growing field. I am pursuing advanced training on lung transplantation at Stanford University Medical Center to help accomplish my dreams.