School of Medicine
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Postdoctoral Scholar, Cardiovascular Medicine
BioI am a postdoc working with Dr. Michael Salerno. My research focus is developing advanced imaging techniques for cardiac magnetic resonance imaging and using deep learning to advance the clinical workflow.
Chad S. Weldy, M.D., Ph.D.
Postdoctoral Medical Fellow, Cardiovascular Medicine
Fellow in Medicine
Resident in Medicine
Current Research and Scholarly InterestsAs a physician-scientist in the lab of Dr. Quertermous I work to understand the genetic basis of cardiovascular disease and the transcriptional and epigenomic mechanisms of atherosclerosis. My work is focused across four main areas of cardiovascular genetics and mechanisms of coronary artery disease and smooth muscle biology:
1.Vascular smooth muscle specific ADAR1 mediated RNA editing of double stranded RNA and activation of the double stranded RNA receptor MDA5
2.Defining on single cell resolution the cellular and epigenomic features of human vascular disease across vascular beds of differing embryonic origin
3.CRISPRi screening with targeted perturb seq (TAPseq) to identify novel CAD genes in human coronary artery smooth muscle cells
4.Investigation of the epigenetic and molecular basis of coronary artery disease and smooth muscle cell transition in mice with conditional smooth muscle genetic deletion of CAD genes Pdgfd and Sox9
My work with Dr. Quertermous is focused on discovery of causal mechanisms of disease through leveraging human genetics with sophisticated molecular biology, single cell sequencing technologies, and mouse models of disease. This work attempts to apply multiple scientific research arms to ultimately lead to novel understandings of vascular disease and discover important new therapeutic approaches for drug discovery.
Grant funding received for this work:
Ruth L. Kirschstein National Research Service Award (NRSA) Individual Postdoctoral Fellowship (F32) (NIH/NHLBI, 1 F32 HL160067-01), July, 2021. PI: Weldy, Chad
• Titled, “A transcriptional network which governs smooth muscle transition is mediated by causal coronary artery disease gene PDGFD”
•*Received perfect score with impact score 10, 1st percentile
NIH Loan Repayment Program (LRP) Award (NIH/NHLBI), July, 2021. PI: Weldy, Chad
•Title of proposal: "Single cell transcriptomic and epigenomic features of human atherosclerosis".
•This will award up to $100,000 towards student loans over the next 24 months with opportunity for renewal after 24 months.
Postdoctoral Scholar, General Internal Medicine
BioDr. Wray is a Human and Planetary Health Postdoctoral Fellow at the Stanford Center for Innovation in Global Health, Stanford Woods Institute for the Environment and London School of Hygiene & Tropical Medicine. Her research focuses on the mental health impacts of climate change on young people ('emerging adults') and frontline community members, socio-emotional resilience and capacity building for vulnerable communities, and public engagement for improved mental wellbeing and planetary health. Dr. Wray has a PhD in Science Communication from the University of Copenhagen and is a journalist, speaker, and author of two books: Generation Dread: Finding Purpose in the Climate Crisis (Knopf 2022) and Rise of the Necrofauna: The Science, Ethics and Risks of De-Extinction (Greystone Books 2017). She has hosted and produced several science radio programs, podcasts and television programs for international broadcasters including the BBC and CBC, and is a TED speaker. Dr Wray is an advisor to the Climate Mental Health Network (addressing the mental health consequences of climate change through community engagement and by harnessing the power of media and technology), Climate Cares (a mental health research collaboration between the Institute of Global Health Innovation and the Grantham Institute at Imperial College London), and the Good Energy Project (a nonprofit unlocking the power of TV and film to inspire courage in the face of climate change).