School of Medicine
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Marguerite Blake Wilbur Professor in Natural Science and Professor, by courtesy, of Physics
Current Research and Scholarly InterestsMy research group is exploring a variety of topics that range from the basic understanding of chemical reaction dynamics to the nature of the chemical contents of single cells.
Under thermal conditions nature seems to hide the details of how elementary reactions occur through a series of averages over reagent velocity, internal energy, impact parameter, and orientation. To discover the effects of these variables on reactivity, it is necessary to carry out studies of chemical reactions far from equilibrium in which the states of the reactants are more sharply restricted and can be varied in a controlled manner. My research group is attempting to meet this tough experimental challenge through a number of laser techniques that prepare reactants in specific quantum states and probe the quantum state distributions of the resulting products. It is our belief that such state-to-state information gives the deepest insight into the forces that operate in the breaking of old bonds and the making of new ones.
Space does not permit a full description of these projects, and I earnestly invite correspondence. The following examples are representative:
The simplest of all neutral bimolecular reactions is the exchange reaction H H2 -> H2 H. We are studying this system and various isotopic cousins using a tunable UV laser pulse to photodissociate HBr (DBr) and hence create fast H (D) atoms of known translational energy in the presence of H2 and/or D2 and using a laser multiphoton ionization time-of-flight mass spectrometer to detect the nascent molecular products in a quantum-state-specific manner by means of an imaging technique. It is expected that these product state distributions will provide a key test of the adequacy of various advanced theoretical schemes for modeling this reaction.
Analytical efforts involve the use of capillary zone electrophoresis, two-step laser desorption laser multiphoton ionization mass spectrometry, cavity ring-down spectroscopy, and Hadamard transform time-of-flight mass spectrometry. We believe these methods can revolutionize trace analysis, particularly of biomolecules in cells.
Postdoctoral Research Fellow, Cardiovascular Institute
BioDr. Hao Zhang is a postdoctoral fellow working with Dr. Joseph Wu at Stanford Cardiovascular Institute. At Stanford, his focus is to develop and optimize differentiation protocol of iPSCs to cardiac fibroblasts, elucidate patient-specific mechanisms of cardiac fibrosis in cell and tissue levels, and utilize high-throughput technology to screen anti-fibrosis drugs. Dr. Zhang received his MD at Peking Union Medical School, Tsinghua University (2013), Beijing. After graduation, he became a cardiologist at Fuwai Hospital. At Peking Union Medical School, Dr. Zhang was trained by his mentor, Dr. Yue-jin Yang, to investigate the microenvironment in the adult heart following ischemic injury, such as myocardial infarction. During his clinical training, Dr. Zhang studied calcified valve disease and TAVR technology in the cardiology department, where he was supervised by Dr. Yong-jian Wu.