School of Medicine
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Associate Professor of Medicine (Pulmonary and Critical Care Medicine)
Current Research and Scholarly Interests1. Development and evaluation of prognostic and diagnostic integral biomarkers in PAH.
2. Prevalence and Treatment of Insulin Resistance in PAH.
3. Role of inflammation and proteomic signature in PAH
4. Development of novel therapeutics (bench to bedside) including FK506 & Elastase Inhibition in PAH.
5. Assessment of Vasoreactivity (gain and loss) in pulmonary arterial hypertension
6. Assessment of microvascular function in PAH.
Marguerite Blake Wilbur Professor of Natural Science and Professor, by courtesy, of Physics
Current Research and Scholarly InterestsMy research group is exploring a variety of topics that range from the basic understanding of chemical reaction dynamics to the nature of the chemical contents of single cells.
Under thermal conditions nature seems to hide the details of how elementary reactions occur through a series of averages over reagent velocity, internal energy, impact parameter, and orientation. To discover the effects of these variables on reactivity, it is necessary to carry out studies of chemical reactions far from equilibrium in which the states of the reactants are more sharply restricted and can be varied in a controlled manner. My research group is attempting to meet this tough experimental challenge through a number of laser techniques that prepare reactants in specific quantum states and probe the quantum state distributions of the resulting products. It is our belief that such state-to-state information gives the deepest insight into the forces that operate in the breaking of old bonds and the making of new ones.
Space does not permit a full description of these projects, and I earnestly invite correspondence. The following examples are representative:
The simplest of all neutral bimolecular reactions is the exchange reaction H H2 -> H2 H. We are studying this system and various isotopic cousins using a tunable UV laser pulse to photodissociate HBr (DBr) and hence create fast H (D) atoms of known translational energy in the presence of H2 and/or D2 and using a laser multiphoton ionization time-of-flight mass spectrometer to detect the nascent molecular products in a quantum-state-specific manner by means of an imaging technique. It is expected that these product state distributions will provide a key test of the adequacy of various advanced theoretical schemes for modeling this reaction.
Analytical efforts involve the use of capillary zone electrophoresis, two-step laser desorption laser multiphoton ionization mass spectrometry, cavity ring-down spectroscopy, and Hadamard transform time-of-flight mass spectrometry. We believe these methods can revolutionize trace analysis, particularly of biomolecules in cells.
Christopher K. Zarins
Walter Clifford Chidester and Elsa Rooney Chidester Professor of Surgery, Emeritus
Current Research and Scholarly InterestsHemodynamic factors in atherosclerosis, pathogenesis of, aortic aneurysms, carotid plaque localization and complication, anastomotic intimal hyperplasia, vascular biology of artery wall, computational fluid dynamics as applied to blood flow and vascular disease.
James L. Zehnder, M.D.
Professor of Pathology (Research) and of Medicine (Hematology)
Current Research and Scholarly InterestsOur laboratory focuses on translational research in 2 main areas - genomic approaches to diagnosis and minimal residual disease testing for patients with cancer, and molecular basis of disorders of thrombosis and hemostasis. My clinical focus is in molecular pathology, diagnosis and treatment of disorders of hemostasis and thrombosis and general hematology.
Assistant Professor of Mechanical Engineering and, by courtesy, of Materials Science and Engineering
BioRuike Renee Zhao is an Assistant Professor of Mechanical Engineering at Stanford University where she directs the Soft Intelligent Materials Laboratory. Renee received her BS degree from Xi'an Jiaotong University in 2012, and her MS and PhD degrees from Brown University in 2014 and 2016, respectively. She was a postdoc associate at MIT during 2016-2018 prior to her appointment as an Assistant Professor in the Department of Mechanical and Aerospace Engineering at The Ohio State University from 2018 to 2021.
Renee’s research concerns the development of stimuli-responsive soft composites for multifunctional robotic systems with integrated shape-changing, assembling, sensing, and navigation. By combining mechanics, polymer engineering, and advanced material manufacturing techniques, the functional soft composites enable applications in soft robotics, miniaturized biomedical devices, flexible electronics, deployable and morphing structures.
Renee is a recipient of the 2022 ASME Henry Hess Early Career Publication Award, 2022 ASME Pi Tau Sigma Gold Medal, 2021 ASME Applied Mechanics Division Journal of Applied Mechanics Award, 2020 NSF Career Award, and 2018 ASME Applied Mechanics Division Haythornthwaite Research Initiation Award.
BioDr. Zhu is a general cardiologist with specialized clinical and research training in cardio-oncology and cardio-immunology. She focuses on the cardiovascular care of patients undergoing therapies for cancer, with a particular focus on the effects of immunotherapies on the heart. She received a bioengineering degree at MIT, medical degree at Case Western Reserve University, and completed clinical cardiology fellowship and internal medicine residency training at Stanford University School of Medicine. Dr. Zhu’s research focuses on myocarditis, cardiac inflammation, and the effects of cancer therapeutics on the cardiovascular system. Her current research employs clinical data, bio-banked samples, and animal models combined with single-cell technologies to study immune-based toxicities in the heart. Dr. Zhu's clinic sees cardio-oncology and cardio-immunology patients and focuses on devising new methods for minimizing cardiovascular complications in the cancer patient population.