School of Medicine
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Associate Professor of Medicine (Pulmonary and Critical Care Medicine)
Current Research and Scholarly Interests1. Development and evaluation of prognostic and diagnostic integral biomarkers in PAH.
2. Prevalence and Treatment of Insulin Resistance in PAH.
3. Role of inflammation and proteomic signature in PAH
4. Development of novel therapeutics (bench to bedside) including FK506 & Elastase Inhibition in PAH.
5. Assessment of Vasoreactivity (gain and loss) in pulmonary arterial hypertension
6. Assessment of microvascular function in PAH.
James L. Zehnder, M.D.
Professor of Pathology (Research) and of Medicine (Hematology)
Current Research and Scholarly InterestsOur laboratory focuses on translational research in 2 main areas - genomic approaches to diagnosis and minimal residual disease testing for patients with cancer, and molecular basis of disorders of thrombosis and hemostasis. My clinical focus is in molecular pathology, diagnosis and treatment of disorders of hemostasis and thrombosis and general hematology.
Tian Yi Zhang, MD, PhD
Assistant Professor of Medicine (Hematology)
BioDr. Zhang is a board-certified hematologist. She is also an assistant professor of hematology at Stanford University School of Medicine. In addition to her medical degree, she holds a PhD in cellular and molecular immunology.
In her clinical practice, she treats patients with all forms of hematological malignancies, offering specialized expertise in acute myeloid leukemia, including therapy-resistant cases. For each patient, she develops a personalized care plan encompassing novel treatment options.
Her research activities include conducting early phase clinical trials, investigator initiated clinical trials (IITs), studying the immune repertoire in patients with myeloid malignancies, and exploring cholesterol metabolic dependencies of acute myeloid leukemia (AML).
She was the recipient of an A.P. Giannini Foundation fellowship award, which supports innovative research. The award helped fund Dr. Zhang’s study of how AML cells interact with other cells in bone marrow. A significant finding confirmed that AML cells secrete a protein that suppresses the production of red blood cells, the same protein that causes inflammation in disorders such as rheumatoid arthritis and Crohn’s disease.
Her many other honors include the National Cancer Institute Career Development (K08) Award, the American Society of Hematology (ASH) Research Training Award for Fellows, Stanford Cancer Institute - American Cancer Society (SCI-ACS) Pilot Grant and Best ASH Abstract Award two years in a row. She also has earned recognition from the National Institutes of Health and American College of Physicians.
She has published her research findings on topics such as advanced therapy for high-risk myelodysplastic syndromes and reversal of bone marrow failure induced by AML. Her work has appeared in Leukemia & Lymphoma, Science Translational Medicine, Cancer Research, the Journal of Clinical Investigation, Journal of Immunology, and elsewhere.
Dr. Zhang is a member of the American Association of Cancer Research and American Society of Hematology. She advises and mentors Stanford medical students, residents and fellows. She delivers invited lectures to faculty and fellows. In addition, she has been an invited speaker on the topic of acute myeloid leukemia at the Association of Northern California Oncologists Update on Hematological Malignancies.
BioDr. Zhu is a general cardiologist with specialized clinical and research training in cardio-oncology and cardio-immunology. She focuses on the cardiovascular care of patients undergoing therapies for cancer, with a particular focus on the effects of immunotherapies on the heart. She completed clinical cardiology fellowship and internal medicine residency training at Stanford University School of Medicine. During her post-doctoral training, Dr. Zhu’s research focuses on myocarditis, cardiac inflammation, and the effects of cancer therapeutics on the cardiovascular system. Her current research employs clinical data, bio-banked samples, and animal models to study T-cell toxicities in the heart. Dr. Zhu's clinic sees cardio-oncology and cardio-immunology patients and focuses on devising new methods for minimizing cardiovascular complications in the cancer patient population.
Clinical Assistant Professor, Medicine - Gastroenterology & Hepatology
BioI am initially a Pittsburgh, PA native, but have been at Stanford University since 2012 for residency, fellowship, and now as faculty. It is exciting to be affiliated with one of the most dynamic and innovative medical institutions worldwide.
My clinical and research interests focus on functional, motility, and esophageal disorders of the gastrointestinal tract. Outside of this sub-sub specialization, a significant portion of my practice is also devoted to the care of a broad range of “general gastroenterology” concerns.
Functional, motility, esophageal, and general gastroenterology disorders are very common, and can cause significant disability. Some examples include irritable bowel syndrome, functional dyspepsia, gastroparesis, chronic nausea, chronic constipation, achalasia, and gastroesophageal reflux disease.
Despite the common nature of these disorders, many are not well understood, leading to frustration among both patients and clinicians alike. Furthermore, there is an incorrect stigma associated with some of these disorders that “it is all in your head.” On the opposite side of the spectrum, there is sometimes an incorrect assumption that we will be able to pinpoint an exact underlying cause in all cases, but this is not possible with current technology. We aim to bridge this gap using the latest diagnostic testing and treatment paradigms, as well as a healing hand. Additionally, our group is actively engaged in multiple research projects and studies to drive the future of the field.
Though I am early in my career, I am hoping that by the end the field will look nothing like it does today. I am hopeful, and I believe that we can revolutionize the field to better characterize gastrointestinal disorders, and come up with highly effective targeted treatments.
Professor of Medicine (Infectious Diseases) at the Stanford University Medical Center, Emeritus
Current Research and Scholarly InterestsDr. Zolopas research applies a variety of clinical epidemiologic methods in an effort to optimize antiretroviral therapy and understand the impact of drug resistance on response to ARV. Areas of focus include the clinical application of resistance testing in optimizing antiretroviral therapy, clinical cohorts, trials of antiretroviral therapies and population-based epidemiologic evaluation of HIV resistance and efficacy of ARV therapy. More recently studies focused on premature aging in HIV.
Associate Professor of Medicine (General Medical Disciplines)
Current Research and Scholarly Interests- Health care delivery models for patients with complex medical, social and behavioral needs.
- Interventions that address social determinants of health
- Effective communication and relationship-building in the clinical context
- Patient-facing technology (e.g., video-based care, eHealth technology) to facilitate access to health care