School of Medicine
Showing 311-320 of 735 Results
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Mark Krasnow
Paul and Mildred Berg Professor
Current Research and Scholarly Interests- Lung development and stem cells
- Neural circuits of breathing and speaking
- Lung diseases including lung cancer
- New genetic model organism for biology, behavior, health and conservation -
Anandi Krishnan
Affiliate, Institute for Immunity, Transplantation, and Infection Operations
Visiting Scholar, Institute for Immunity, Transplantation, and Infection OperationsBioDr. Krishnan is a translational scientist with experiences in engineering, biosciences, molecular genetics and hematology. Having recently completed her NIH clinical scientist career development award (NHGRI 1K08HG010061-01A1, 2018-24), and NIH-supported research re-entry (NCATS 3UL1TR001085-04S1, 2016-18), Anandi’s interests are in expanding our understanding of the multifaceted function of anucleate blood platelets and their parent megakaryocytes in human disease.
Her current work, applying platelet transcriptome profiling and machine learning principles, aims to nominate novel clinically relevant strategies for personalized cancer and antiplatelet/antithrombotic therapy. Continued development of this research is likely to identify key mechanistic variables in platelet- and megakaryocyte-specific response to health and disease.
Recent contributions in both computational and mechanistic components of platelet and blood research lay the groundwork for sustaining contributions to the field of hematology genomic medicine (e.g. Shen et al PMID 34755136, Seetharam et al PMID 36712071, Kelliher et al PMID 37961700, Thomas & Krishnan PMID 38175681, Abbonante et al PMID 38165147, Jutzi et al PMID 35763665, Campbell et al PMID 36194487). Anandi was also was one of the first non-MD PhD scientist to be awarded the NHGRI K08 Clinical Scientist Research Career Development Award, the HTRS Mid-Career Research Award, and the MPN Research Foundation Challenge Grant Award, reflecting her consistent efforts bridging basic and clinical disciplines.
Select other recognitions include:
Member, Editorial Board, Journal of Thrombosis and Haemostasis (2024-)
Ad hoc Reviewer, NIH CSR Cancer and Hematological Disorders Study Section (2023, 24)
Host Mentor, ISTH Training Fellowship, International Society for Thrombosis and Haemostasis (2023)
Member, Minority Recruitment Initiatives Subcommittee, American Society of Hematology (2022-26)
Team Science Leadership Program at Stanford Medicine (2022)
Peer Mentor, Pathology Stanford Network for Advancement and Promotion (2021)
Research Mentor, Meharry Medical College, Nashville, Meharry-Stanford initiative *mentee selected for oral presentation & won 2nd place at Meharry (2021)
Thrombosis & Hemostasis Societies of North America Young Investigator Award (2020)
Invited Member and Panelist, NSF RESET Conference (2020)
Invited Member/Panelist, iRelaunch Return to Work Conference, Stanford Alumni Association (2018)
Featured twice by NIH NCATS in the ‘Features & Briefs’ & ‘Diversity Awardee Profiles’ webpages (2017,18)
Complete list of publications: https://pubmed.ncbi.nlm.nih.gov/?term=anandi+krishnan&sort_order=asc -
Thomas M. Krummel, MD, FACS/FAAP
Emile Holman Professor, Emeritus
Current Research and Scholarly InterestsSurgical Innovation, Simulation and Virtual Reality in Surgical Education, Fetal Healing-Cellular and Biochemical Mechanisms
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Kristina Kudelko
Clinical Professor, Medicine - Pulmonary, Allergy & Critical Care Medicine
Current Research and Scholarly InterestsDrugs and toxins-associated pulmonary arterial hypertension, clinical outcomes research, evaluating the long-term impacts of a standardized pulmonary vascular disease fellowship training program
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Ellen Kuhl
Catherine Holman Johnson Director of Stanford Bio-X, Walter B Reinhold Professor in the School of Engineering, Professor of Mechanical Engineering and, by courtesy, of Bioengineering
Current Research and Scholarly Interestscomputaitonal simulation of brain development, cortical folding, computational simulation of cardiac disease, heart failure, left ventricular remodeling, electrophysiology, excitation-contraction coupling, computer-guided surgical planning, patient-specific simulation
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Calvin Kuo
Maureen Lyles D'Ambrogio Professor
Current Research and Scholarly InterestsWe study cancer biology, intestinal stem cells (ISC), and angiogenesis. We use primary organoid cultures of diverse tissues and tumor biopsies for immunotherapy modeling, oncogene functional screening and stem cell biology. Angiogenesis projects include blood-brain barrier regulation, stroke therapeutics and anti-angiogenic cancer therapy. ISC projects apply organoid culture and ko mice to injury-inducible vs homeostatic stem cells and symmetric division mechanisms.
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Christin S Kuo
Assistant Professor of Pediatrics (Pulmonary Medicine)
BioDr. Kuo is a physician-scientist with expertise in single-cell genomics and pulmonary medicine. She has made pioneering contributions to pulmonary neuroendocrine cell (PNEC) biology by developing innovative strategies that established the first comprehensive framework for understanding the molecular and cellular diversity of normal PNECs and their roles in health and disease. Her discoveries have laid the foundation for this emerging field and her contributions are recognized internationally.
PNECs are exceedingly rare lung epithelial cells with specialized airway sensory, secretory, and stem cell functions. These neurosensory cells are thought to monitor airway oxygen, chemicals, mechanical deformation, infection, and injury, and serve as sentinels that signal this sensory information locally in the lung, to the brain through synapses with pulmonary sensory neurons and potentially globally throughout the body via secretion of myriad local signals and hormones. PNECs are also known to play critical roles in the control of breathing, cough, and respiratory physiology. Among their diverse physiologic functions, their response to injury has been most intensively studied in murine models and they are a cell of origin for high grade lung neuroendocrine tumors.
Dr. Kuo performed the first comprehensive anatomical mapping and lineage tracing studies of PNECs in mice which generated a foundational understanding of PNEC development (Kuo and Krasnow, Cell 2015). She also led single cell transcriptomic profiling studies that revealed a surprising diversity in PNEC sensors and signals (Kuo et al, eLife 2022). PNECs express over 25 different sensory receptor genes ("sensors") and over 40 different neuropeptide and peptide hormone genes ("signals"). Her scRNA-seq analysis of PNECs revealed a remarkable number and diversity of PNEC neuropeptide signals and their predicted cellular targets both within the lung and to innervating sensory neurons (Kuo et al., 2022, eLife).
In contrast to the advanced understanding of PNEC development, stem cell, and signaling function in mouse, little is known about human PNECs. To compare the findings of PNEC development, diversity, and function in mouse models to human diseases, her lab recently established a platform to systematically construct a human PNEC atlas. This foundational work created a molecular and anatomic framework for the entire human pulmonary neuroendocrine system and the diseases that are predicted to originate from distinct PNECs. Her lab has recently used this new PNEC atlas combined with single cell transcriptomic approaches to identify the molecular diversity of anatomically and functionally distinct human PNECs.
Dr. Kuo's studies with human models extends her lab’s current research aims to define the diverse neuroendocrine sensory and signaling interactions and the molecules that mediate them to their roles in lung cancer, neuroendocrine proliferative disorders such as diffuse idiopathic neuroendocrine cell hyperplasia (DIPNECH), neuroendocrine cell hyperplasia of infancy (NEHI) and major inflammatory and obstructive pulmonary diseases. Dr. Kuo’s lab engages a network of collaborators to develop and implement clinical protocols and strategically apply cutting-edge technologies to studying minor, but physiologically diverse airway sentinels.
Please visit the research website for additional information and current research areas (https://kuo.stanford.edu). -
WILLIAM T. KUO, MD, FSIR, FCCP, FSVM, FACR, FCIRSE
Professor of Radiology (Interventional Radiology)
Current Research and Scholarly Interests1) LASER-ASSISTED AND COMPLEX IVC FILTER RETRIEVAL
2) CATHETER-DIRECTED THERAPY FOR ACUTE PULMONARY EMBOLISM
3) INTERNATIONAL PE REGISTRY
4) IVC FILTER REGISTRY
5) ENDOVASCULAR TREATMENT OF CAVAL AND DEEP VENOUS THROMBOSIS
