School of Medicine
Showing 591-600 of 1,214 Results
-
Yunkyeong Lee
Postdoctoral Scholar, Endocrinology and Metabolism
BioYun is a postdoctoral research scholar in the Translational Genomics of Diabetes Laboratory under the mentorship of Dr. Anna Gloyn. Since joining the lab in August 2022, she has been investigating type 2 diabetes (T2D) susceptible genes and their molecular mechanisms in pancreatic β-cell dysfunction and the development of T2D. Her primary focus is on how T2D effector transcripts alter autophagy/mitophagy pathways in human pancreatic β-cells, contributing to β-cell failure, mitochondrial dysfunction, and T2D pathology. She also investigated the impact of genetic mutations underlying neonatal diabetes using CRISPR HDR knockin genome editing in human induced pluripotent stem cell (hiPSC) models and their derivatives.
During her PhD, she explored the role of an epigenetic regulator and its molecular machinery in the pathogenesis of non-alcoholic fatty liver disease (NAFLD), now termed metabolic dysfunction-associated steatotic liver disease (MASLD). In parallel, she studied the interplay between endoplasmic reticulum (ER) stress-mediated unfolded protein response (UPR) signalling and autophagy, and examined how these processes are modulated by bioactive plant extracts in various cellular contexts.
She is particularly interested in exploring inter-organ communication, such as pancreas-liver-heart crosstalk, and how these interactions influence systemic metabolism and contribute to the onset and progression of T2D, along with its complications. Her long-term research goal is to advance our understanding of the cellular and molecular mechanisms driving T2D and to identify novel therapeutic targets and strategies. -
Christopher Lee-Messer, MD, PhD
Clinical Associate Professor, Pediatric Neurology
Clinical Associate Professor (By courtesy), PediatricsCurrent Research and Scholarly InterestsMy chief clinical focus is in pediatric epilepsy, especially how epilepsy affects learning and development. For my research, I background in neural development and computational neuroscience towards developing better learning algorithms and applying the latest techniques in machine learning for better diagnosis and treatment of disease.
-
John Leikauf
Clinical Associate Professor, Psychiatry and Behavioral Sciences - Child & Adolescent Psychiatry and Child Development
Current Research and Scholarly InterestsI am interested in better understanding the heterogeneous cognitive and electrophysiological abnormalities in children with ADHD and the many other conditions that commonly co-occur with ADHD. The long-term goal is to be able to better target treatments to specific deficits in order to promote long-term health and well-being and improve outcomes that matter to individuals and families suffering from these disorders.
-
Mary Leonard
Arline and Pete Harman Professor, Professor of Pediatrics (Nephrology), of Medicine (Nephrology) and, by courtesy, of Epidemiology and Population Health
Current Research and Scholarly InterestsMy multidisciplinary research program is focused on (1) the detrimental effects of glucocorticoids, sarcopenia and inflammation on bone development in pediatric diseases, (2) the long-term effects of childhood cancer on bone and muscle quality, (3) the assessment of renal osteodystrophy using novel micro-imaging techniques, (4) the effects of vitamin D deficiency on physical function and cardiovascular disease, and (5) the evaluation of biomechanical interventions as anabolic bone therapies.
-
Stephanie A. Leonard
Assistant Professor (Research) of Obstetrics and Gynecology (Maternal Fetal Medicine) and, by courtesy, of Anesthesiology, Perioperative & Pain Medicine
BioStephanie Leonard, PhD, MS, is an Assistant Professor in the Dunlevie Maternal-Fetal Medicine Center for Discovery, Innovation, and Clinical Impact (https://dunleviemfm.stanford.edu/) and holds a courtesy appointment in Anesthesiology, Perioperative and Pain Medicine.
The goal of Dr. Leonard’s research is to advance equitable, positive health experiences and outcomes for pregnant individuals and newborns. She is interested in applying transdisciplinary methods to perinatal health research, with a focus on studying pregnancy-related morbidities in large data sources. Currently, her primary research interests are in building an infrastructure for distributed data network studies of perinatal health and improving treatment of chronic hypertension in pregnancy. To this end, she co-launched the OHDSI Pregnancy and Reproductive Health Work Group (https://www.ohdsi.org/workgroups/) and collaborates closely with the Harvard Program on Perinatal and Pediatric Pharmacoepidemiology (http://www.harvardpreg.org/). She also serves as a collaborator and mentor on a variety of obstetrics studies, including clinical trials, prospective and retrospective observational studies, and qualitative studies. Dr. Leonard's research program is currently funded by NHLBI (K01) and NICHD (U54).
Dr. Leonard trained in epidemiology at UCLA (MS) and UC Berkeley (PhD), where her research focused on nutrition in pregnancy and was completed in partnership with the WIC program and the Nutrition Policy Institute. She completed a postdoc in Neonatal and Developmental Medicine at Stanford as part of the Stanford Center for Population Health Sciences. -
Marc Levenston
Associate Professor of Mechanical Engineering and, by courtesy, of Radiology (Radiological Sciences Laboratory)
Current Research and Scholarly InterestsMy lab's research involves the function, degeneration and repair of musculoskeletal soft tissues, with a focus on meniscal fibrocartilage and articular cartilage. We are particularly interested in the complex interactions between biophysical and biochemical cues in controlling cell behavior, the roles of these interactions in degenerative conditions such as osteoarthritis, and development of tissue engineered 3D model systems for studying physical influences on primary and progenitor cells.
-
Maayan Levy
Assistant Professor of Pathology
Current Research and Scholarly InterestsThe Levy Lab studies how microbiome-brain interactions influence metabolism, behavior, and disease. By investigating how microbial signals affect neural circuits, we explore mechanisms underlying obesity, diabetes, and psychiatric conditions. The lab seeks to uncover new therapeutic targets using advanced neuroscience tools like optogenetics and imaging. Our research aims to improve understanding of how microbiome imbalances contribute to disease and how restoring balance can promote health.
-
David B. Lewis
Naddisy Foundation Professor of Pediatric Food Allergy, Immunology, and Asthma
Current Research and Scholarly InterestsMy laboratory is focused on defining cellular and molecular mechanisms that limit T cell responses to vaccines and pathogens during normal early postnatal development and in cases of inherited genetic immunodeficiencies. We are also determinomg how these limitations in immunity can be overcome by using novel approaches for vaccine adjuvants for influenza vaccine and by using catalytically inactive Cas proteins for inducing endogenous gene expression.
-
Gordon Li, MD
Professor of Neurosurgery and, by courtesy, of Neurology and Neurological Sciences and of Otolaryngology - Head & Neck Surgery (OHNS)
Current Research and Scholarly Interests1.) My laboratory studies the biology of brain tumors with the goal of developing novel therapeutics for the treatment of malignant brain tumors and translating that research into clinical trials.
2.) My clinical interests include improving surgical techniques for brain tumor surgery, immunotherapy for the treatment of glioblastoma, and novel uses for stereotactic radiosurgery.
