School of Medicine
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Jared and Mae Tinklenberg Professor and Professor, by courtesy, of Neurology
Current Research and Scholarly InterestsWe study cognitive processes and aging in our research center. Studies range from molecular biology to neuropsychology of cognitive processes.
Jong H. Yoon
Professor of Psychiatry and Behavioral Sciences (Public Mental Health & Population Sciences)
Current Research and Scholarly InterestsMy research seeks to discover the brain mechanisms responsible for schizophrenia and to translate this knowledge into the clinic to improve how we diagnose and treat this condition. Towards these ends, our group has been developing cutting-edge neuroimaging tools to identify neurobiological abnormalities and test novel systems-level disease models of psychosis and schizophrenia directly in individuals with these conditions.
We have been particularly interested in the role of neocortical-basal ganglia circuit dysfunction. A working hypothesis is that some of the core symptoms of schizophrenia are attributable to impairments in neocortical function that results in disconnectivity with components of the basal ganglia and dysregulation of their activity. The Yoon Lab has developed new high-resolution functional magnetic resonance imaging methods to more precisely measure the function of basal ganglia components, which given their small size and location deep within the brain has been challenging. This includes ways to measure the activity of nuclei that store and control the release of dopamine throughout the brain, a neurochemical that is one of the most important factors in the production of psychosis in schizophrenia and other neuropsychiatric conditions.
Lindsey Eileen Zimmerman
Affiliate, Psych/Public Mental Health & Population Sciences
BioLindsey Zimmerman, PhD, is a Clinical and Community Psychologist, and Implementation Scientist at the National Center for PTSD, Dissemination and Training Division of the Veterans Health Administration.
Dr. Zimmerman is principal investigator of National Institutes of Health (NIH) and Veterans Health Administration (VA) research that enlists participatory system dynamics to increase timely patient access to evidence-based pharmacotherapy and evidence-based psychotherapy for depression, PTSD, alcohol and opioid use disorder. See https://mtl.how/team
Active NIH Grants
Participatory System Dynamics vs Audit and Feedback: A Cluster Randomized Trial of Mechanisms Of Implementation Change to Expand Reach of Evidence-Based Addiction and Mental Health Care (R01DA046651)
The most common reasons Veterans seek VA addiction and mental health care is for help with opioid and alcohol misuse, depression and PTSD. Research evidence has established highly effective treatments that prevent relapse, overdose and suicide, but even with policy mandates, performance metrics, and electronic health records to fix the problem, these treatments may only reach 3-28% of patients. This study tests participatory business engineering methods to better meet the addiction and mental health needs of Veterans and the U.S. population.
Participatory System Dynamics for Evidence-Based Addiction and Mental Healthcare (R21DA042198)
Limited access and delays to high-quality, evidence-based mental health and addiction treatments can lead to patients getting too little or ineffective care and contribute to chronic patient impairment, relapse, and death by suicide or overdose. This study evaluates a system for resolving problems with patient flow and organization in health care systems, using electronic medical record systems and a high-level of input from healthcare leadership, frontline providers and patients.
Active VA Grants
Participatory System Dynamics vs Usual Quality Improvement: Is Staff Use of Simulation an Effective, Scalable and Affordable Way to Improve Timely Veteran Access to High-quality Mental Health Care? (I01HX002521)
Participatory system dynamics (PSD) helps improve quality with existing resources, critical in mental health and all VA health care. PSD uses learning simulations to improve staff decisions, showing how goals for quality can best be achieved given local resources and constraints. We aim to significantly increase the proportion of patients who start and complete evidence-based care, and determine the costs of using PSD for improvement.
2019 National Institutes of Health, Center for Scientific Review
Community Influences on Health Behavior (CIHB) Study Section
2019-present VA Quality Enhancement Research Initiative (QUERI)
QUERI/Health Services Research & Development, Scientific Merit Review Committee
2019-present Emory University
Prolonged Exposure Consultant Training Program Advisory Board
2018-present National Institutes of Health
Training Institute for Dissemination and Implementation Research in Health (TIDIRH)
Mental Health Faculty Mentor
2015-2017 National Institutes of Health Loan Repayment Program
National Institute of Mental Health Clinical Research Review Committee
Quality Improvement and Systems of Care Competencies
Psychiatry & Behavioral Sciences Residency, Stanford University School of Medicine & VA Palo Alto Health Care System
Postdoctoral Research Fellowship Program Seminar
VA Palo Alto research centers of the National Center for PTSD (NCPTSD), Center for Innovation to Implementation (Ci2i), Mental Illness Research Education and Clinical Care (MIRECC), and War-related Illness and Injury Study Center (WRIISC).
Open Science Resources for the Modeling to Learn Simulation Learning Program are available on GitHub at https://mtl.how and https://mtl.how/demo