School of Medicine
Showing 11-20 of 140 Results
Helen M. Blau
Donald E. and Delia B. Baxter Foundation Professor, Director, Baxter Laboratory for Stem Cell Biology and Professor, by courtesy, of Psychiatry and Behavioral Sciences
Current Research and Scholarly InterestsProf. Helen Blau's research area is regenerative medicine with a focus on stem cells. Her research on nuclear reprogramming and demonstrating the plasticity of cell fate using cell fusion is well known and her laboratory has also pioneered the design of biomaterials to mimic the in vivo microenvironment and direct stem cell fate. Current findings are leading to more efficient iPS generation, cell based therapies by dedifferentiation a la newts, and discovery of novel molecules and therapies.
Professor of Pathology and of Microbiology and Immunology and, by courtesy, of Chemical and Systems BiologyOn Leave from 03/01/2023 To 12/31/2023
Current Research and Scholarly InterestsOur lab uses chemical, biochemical, and cell biological methods to study protease function in human disease. Projects include:
1) Design and synthesis of novel chemical probes for serine and cysteine hydrolases.
2) Understanding the role of hydrolases in bacterial pathogenesis and the human parasites, Plasmodium falciparum and Toxoplasma gondii.
3) Defining the specific functional roles of proteases during the process of tumorogenesis.
4) In vivo imaging of protease activity
Associate Professor of Medicine (Infectious Diseases) and of Microbiology and Immunology
Current Research and Scholarly InterestsWe seek to understand how interactions between bacteria, bacteriophages, and the human immune system impact our health and disease. Our goals are to gain insights into the pathogenesis of bacterial infections and to generate novel therapies to improve human health.
Burt and Marion Avery Professor of Immunology, Emeritus
Current Research and Scholarly InterestsWe are intereseted in the interaction between the protozoan parasite Toxoplasma gondii and its mammalian host. We use a combination of molecular and genetic tools to understand how this obligate intracellular parasite can invade almost any cell it encounters, how it co-opts a host cell once inside and how it evades the immune response to produce a life-long, persistent infection.
Associate Professor of Microbiology and Immunology
Current Research and Scholarly InterestsOur research focuses on the identification of host genes that play critical roles in the pathogenesis of infectious agents including viruses. We use haploid genetic screens in human cells as an efficient approach to perform loss-of-function studies. Besides obtaining fundamental insights on how viruses hijack cellular processes and on host defense mechanisms, it may also facilitate the development of new therapeutic strategies.
Postdoctoral Scholar, Microbiology and Immunology
BioI am a postdoctoral researcher in the lab of Prof. Priscilla Yang since September 2021. I am interested in virus-induced changes in membrane lipid composition of infected cells and my research focuses on developing experimental systems to interrogate the impact of lipid composition on membrane-associated RNA virus replication, using hepatitis C virus and brome mosaic virus as model systems.
During my doctoral studies, under the supervision of Prof. ALN Rao at the University of California-Riverside, I investigated capsid dynamics in multipartite bromoviruses, a group of icosahedral, plant-pathogenic RNA viruses belonging to the alphavirus-like super-family.