School of Medicine
Showing 61-70 of 169 Results
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Jody Elizabeth Hooper
Associate Professor of Pathology
Current Research and Scholarly InterestsI am the Director of the Research Autopsy Collaboration at Stanford (RACS) to collect organs and tissues from decedent donors for cancer and disease research. https://med.stanford.edu/racs
I have a number of research interests associated with my autopsy work, including how the time interval between death and collection (the PMI) affects the condition and research viability of the collected tissue, how valuable blood and tissue cultures behave after death, and how autopsy results affect clinical practice in an established information loop. I have projects exploring physician and family attitudes towards autopsy and the utilization of rapid autopsy tissue in characterizing cancer evolution from genetic and immunologic standpoints. -
Dikran Horoupian
Professor (Clinical) of Pathology, Emeritus
Current Research and Scholarly InterestsNeuropathology of:
1. Neurodegenerative diseases
2. Neurodevelopmental disorders
3. CNS neoplasms
4. Nerve & muscle diseases -
Brooke Howitt
Associate Professor of Pathology
BioDr. Howitt is a gynecologic and sarcoma pathologist, with academic interests in gynecologic mesenchymal tumors and morphologic and clinical correlates of molecular alterations in gynecologic neoplasia.
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Michael R. Howitt
Assistant Professor of Pathology and of Microbiology and Immunology
Current Research and Scholarly InterestsOur lab is broadly interested in how intestinal microbes shape our immune system to promote both health and disease. Recently we discovered that a type of intestinal epithelial cell, called tuft cells, act as sentinels stationed along the lining of the gut. Tuft cells respond to microbes, including parasites, to initiate type 2 immunity, remodel the epithelium, and alter gut physiology. Surprisingly, these changes to the intestine rely on the same chemosensory pathway found in oral taste cells. Currently, we aim to 1) elucidate the role of specific tuft cell receptors in microbial detection. 2) To understand how protozoa and bacteria within the microbiota impact host immunity. 3) Discover how tuft cells modulate surrounding cells and tissue.
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Chris C.S. Hsiung
Instructor, Pathology
BioI am a molecular biologist and laboratory medicine physician. I am interested in understanding how cells turn genes on or off, and engineering ways we can turn genes on or off for biological discovery and therapeutic benefit.
In my postdoctoral work advised by Dr. Luke Gilbert (Arc Institute), I developed multiAsCas12a (multiplexed transcriptional interference Acidaminococcus Cas12a), a new functional genomics platform capable of higher-order combinatorial chromatin targeting of multiple coding and non-coding genetic elements per cell, including in pooled 6-plex CRISPRi screens. I proposed a group testing experimental framework to efficiently survey higher-order combinatorial spaces of genetic perturbations. I applied this approach to discover new enhancer elements and dissect the combinatorial logic of cis-regulatory elements. This work is available as a preprint: https://www.biorxiv.org/content/10.1101/2023.09.18.558350v2
In my prior work as an MD-PhD student co-advised by Dr. Arjun Raj and Dr. Gerd Blobel at the Univ. of Pennsylvania, I led several studies focused on how gene regulatory information is maintained or altered through mitosis in mammalian cells, using epigenomics methods, single-molecule RNA imaging, and computational analysis. -
Peter K. Jackson
Professor of Microbiology and Immunology (Baxter Labs) and of Pathology
Current Research and Scholarly InterestsCell cycle and cyclin control of DNA replication .
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Siddhartha Jaiswal
Assistant Professor of Pathology
Current Research and Scholarly InterestsWe identified a common disorder of aging called clonal hematopoiesis of indeterminate potential (CHIP). CHIP occurs due to certain somatic mutations in blood stem cells and represents a precursor state for blood cancer, but is also associated with increased risk of cardiovascular disease and death. We hope to understand more about the biology and clinical implications of CHIP using human and model system studies.
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Kristin Jensen
Associate Professor of Pathology
Current Research and Scholarly InterestsI am a clinical translational investigator with a primary interest in breast cancer biology, and the use of investigational and clinical ancillary techniques such as gene and tissue microarray analysis and immunohistochemistry in the diagnosis and prognosis of this disease. As a practicing cytopathologist, I also have an interest in improving the fine needle aspiration biopsy diagnosis of breast lesions, again using immunohistochemistry and gene expression analysis as adjuncts to cytomorphology.
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Neeraja Kambham
Professor of Pathology
Current Research and Scholarly InterestsDr. Kambham's research interests primarily involve medical diseases and transplantation pathology of the kidney and liver.
