Stanford University
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Stephen J. Galli, MD
Mary Hewitt Loveless, MD, Professor in the School of Medicine and Professor of Pathology and of Microbiology and Immunology
Current Research and Scholarly InterestsThe goals of Dr. Galli's laboratory are to understand the regulation of mast cell and basophil development and function, and to develop and use genetic approaches to elucidate the roles of these cells in health and disease. We study both the roles of mast cells, basophils, and IgE in normal physiology and host defense, e.g., in responses to parasites and in enhancing resistance to venoms, and also their roles in pathology, e.g., anaphylaxis, food allergy, and asthma, both in mice and humans.
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Leonor García-Bayona
Assistant Professor of Microbiology and Immunology
Current Research and Scholarly InterestsThe human microbiome is evolving rapidly (i.e. over our lifetimes) following changes in modern lifestyles, especially in industrialized countries. The García-Bayona lab seeks to understand how horizontal gene transfer shapes interactions within the human intestinal microbiota and what the implications of this widespread phenomenon are for community properties relevant to human health (for example, the ability of the gut community to recover after antibiotic treatment). There is currently only a superficial understanding of the different cellular roles of most exchanged genes, the mechanisms governing their spread and their effect community dynamics. Our lab works on bridging the existing gap between the current systems-level observational studies and a mechanistic understanding through bacterial genetics and physiology. We take a bottom-up approach (from genes to communities), incorporating genetics, metagenomics, population analyses and experimental evolution in tractable bacterial consortia.
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Matthias Garten
Assistant Professor of Microbiology and Immunology and of Bioengineering
Current Research and Scholarly InterestsWith a creative, collaborative, biophysical mindset, we aim to understand the ability non-model organisms to interface with environment to a point at which we can exploit the mechanisms finding cures against diseases and use the mechanisms as tools that we can use to engineer the environment. By developing approaches that allow a quantitative understanding and manipulation of molecular transport our research makes non-model organisms accessible to researchers and engineers.
Specifically, we are studying how the malaria parasite takes control over red blood cells. By learning the biophysical principles of transport in between the host and the parasite we can design ways to kill the parasite or exploit it to reengineer red blood cells. The transport we study is broadly encompassing everything from ions to lipids and proteins. We use variations of quantitative microscopy and electrophysiology to gain insight into the unique strategies the parasite evolved to survive. -
Jeffrey S. Glenn, M.D., Ph.D.
Joseph D. Grant Professor and Professor of Microbiology and Immunology
Current Research and Scholarly InterestsDr. Glenn's primary interest is in molecular virology, with a strong emphasis on translating this knowledge into novel antiviral therapies. Other interests include exploitation of hepatic stem cells, engineered human liver tissues, liver cancer, and new biodefense antiviral strategies.