Stanford University
Showing 631-640 of 829 Results
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Daniel Stack
Associate Professor of Chemistry
BioResearch in the Stack group focuses on the mechanism of dioxygen activation and the subsequent oxidative reactivity with primarily copper complexes ligated by imidazoles or histamines. Specifically, the group is interested in substrate hydroxylations and full dioxygen reduction. The remarkable specificity and energy efficiency of metalloenzymes provide the inspiration for the work. Trapping and characterizing immediate species, primarily at low temperatures, provide key mechanistic insights especially through substrate reactivity along with spectroscopic and metrical correlation to DFT calculations. Our objective is to move these efficient enzymatic mechanisms into small synthetic complexes, not only to reproduce biological reactivity, but more importantly to move the oxidative mechanism beyond that possible in the protein matrix.
Daniel Stack was born, raised and attended college in Portland Oregon. He received his B.A. from Reed College in 1982 (Phi Beta Kappa), working with Professor Tom Dunne on weak nickel-pyrazine complexes. In Boston, he pursued his doctoral study in synthetic inorganic chemistry at Harvard University (Ph.D., 1988) with Professor R. H. Holm, investigating site-differentiated synthetic analogues of biological Fe4S4 cubanes. As an NSF Postdoctoral Fellow with Professor K. N. Raymond at the University of California at Berkeley, he worked on synthesizing new, higher iron affinity ligands similar to enterobactin, a bacterial iron sequestering agent. He started his independent career in 1991 at Stanford University primarily working on oxidation catalysis and dioxygen activation, and was promoted to an Associate Professor in 1998. His contributions to undergraduate education have been recognized at the University level on several occasions, including the Dinkelspiel Award for Outstanding Contribution to Undergraduate Education in 2003.
Areas of current focus include:
Copper Dioxygen Chemistry
Our current interests focus on stabilizing species formed in the reaction of dioxygen with Cu(I) complexes formed with biologically relevant imidazole or histamine ligation. Many multi-copper enzymes ligated in this manner are capable of impressive hydroxylation reactions, including oxidative depolymerization of cellulose, methane oxidation, and energy-efficient reduction of dioxygen to water. Oxygenation of such complexes at extreme solution temperatures (-125°C) yield transient Cu(III) containing complexes. As Cu(III) is currently uncharacterized in any biological enzyme, developing connections between the synthetic and biological realms is a major focus.
Surface Immobilization of Catalysts in Mesoporous Materials
In redox active biological metal sites, the ligation environment is coupled tightly to the functional chemistry. Yet, the metal sites are also site-isolated, creating species that may only have a transient existence in a homogeneous solution. Site isolation of synthetic complexes can be achieved synthetically by supporting the metal complex on a solid matrix. Movement of these complexes into silica based materials or onto electroactive carbon electrodes represent a new direction for the group in the development of bio-inspired metal-based catalysts. -
Diane Stafford
Clinical Professor, Pediatrics - Endocrinology and Diabetes
BioDr. Stafford specializes in Pediatric Endocrinology with special interest in disorders of puberty and Prader-Willi syndrome (PWS). Her research interests include in medical education curriculum development, faculty development and endocrine dysfunction in PWS.
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Randall Stafford
Professor of Medicine (Stanford Center for Research in Disease Prevention)
Current Research and Scholarly InterestsAs Director of the SPRC Program on Prevention Outcomes and Practices, my work focuses on cardiovascular disease treatment and prevention, the adoption of new technology and practices, and patterns of physician practice, particularly medication prescribing. Specific interests include measuring and improving the quality of outpatient care, disparities in health care by race, gender, age and socioeconomic status, and interventions to improve prevention outcomes.
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Jeremy Stanek
Clinical Assistant Professor, Orthopaedic Surgery
BioDr. Jeremy Stanek is a sports medicine physiatrist who specializes in performing arts medicine, sports medicine, and musculoskeletal medicine. He enjoys treating musicians, dancers, athletes of all abilities, and anyone who wants to become or stay active. He performs diagnostic ultrasound as well as ultrasound-guided and fluoroscopic-guided procedures.
Dr. Stanek grew up on a small farm near the town of Qulin, Missouri. He received degrees in music performance from the University of Missouri and University of New Mexico and had a career as a professional trumpet player until developing focal dystonia (musicians' dystonia). Wanting to utilize his experience and education as a performer, he chose medicine as his next career. He graduated from the University of Missouri School of Medicine then completed his intern year at the Medical College of Wisconsin, followed by advanced residency training in physiatry (physical medicine & rehabilitation) at the University of Missouri. In 2018, Dr. Stanek completed a fellowship in sports medicine at Washington University in St. Louis, where he also was a provider in the Medical Program for Performing Artists, treating members of the St. Louis Ballet and his former colleagues in the St. Louis Symphony and community bands and orchestras. He has also provided coverage for a variety of events such as MMA fights, endurance sports events, and was a team physician for Washington University Athletics.
He conducts research in performing arts medicine and has given numerous conference presentations. Additionally, he enjoys speaking with professional and student musicians/dancers to educate them on arts medicine and avoiding injuries. In his free time, he enjoys working on old cars, baking, and participating in triathlons and other endurance sports. -
Konstantina M. Stankovic, MD, PhD, FACS
Bertarelli Foundation Professor and Professor of Otolaryngology - Head & Neck Surgery (OHNS) and, by courtesy, of Neurosurgery
Current Research and Scholarly InterestsOur investigative efforts are organized along 3 research thrusts:
1. Vestibular schwannoma: uncovering mechanisms of sensorineural hearing loss (SNHL) and identifying better therapies;
2. High-resolution imaging of the inner ear;
3. Novel sensing of and therapies for SNHL.
Given the complex, multifaceted nature of these problems, our approach to them involves domain-specific customization and fusion of tools from molecular biology, systems neuroscience, biotechnology and otologic surgery. -
Donald Stanski
Professor of Anesthesia, Emeritus
Current Research and Scholarly InterestsPharmacokinetics and dynamics of anesthetic drugs.
