Stanford University
Showing 121-130 of 148 Results
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Stephen Skirboll
Associate Professor of Neurosurgery
On Leave from 06/24/2024 To 09/06/2024Current Research and Scholarly InterestsMy research focuses on screening strategies to identify and characterize cancer stem cells (CSCs) in human gliomas. We are pursuing this in several ways: 1) a novel colony-forming antibody live cell array to identify distinct CSC surface phenotypes, 2) RNAi screens to identify kinases critical for CSC tumorigenicity, 3) high throughput small molecule and chemical screens to identify compounds that selectively kill or target CSCs, and 4) identifying CSCs using the tumor specific EGFRvIII
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Ivan Soltesz
James R. Doty Professor of Neurosurgery and Neurosciences
BioIvan Soltesz received his doctorate in Budapest and conducted postdoctoral research at universities at Oxford, London, Stanford and Dallas. He established his laboratory at the University of California, Irvine, in 1995. He became full Professor in 2003, and served as department Chair from 2006 to July 2015. He returned to Stanford in 2015 as the James R. Doty Professor of Neurosurgery and Neurosciences at Stanford University School of Medicine. His major research interest is focused on neuronal microcircuits, network oscillations, cannabinoid signaling and the mechanistic bases of circuit dysfunction in epilepsy.
His laboratory employs a combination of closely integrated experimental and theoretical techniques, including closed-loop in vivo optogenetics, paired patch clamp recordings, in vivo electrophysiological recordings from identified interneurons in awake mice, 2-photon imaging, machine learning-aided 3D video analysis of behavior, video-EEG recordings, behavioral approaches, and large-scale computational modeling methods using supercomputers. He is the author of a book on GABAergic microcircuits (Diversity in the Neuronal Machine, Oxford University Press), and editor of a book on Computational Neuroscience in Epilepsy (Academic Press/Elsevier). He co-founded the first Gordon Research Conference on the Mechanisms of neuronal synchronization and epilepsy, and taught for five years in the Ion Channels Course at Cold Springs Harbor. He has over 30 years of research experience, with over 20 years as a faculty involved in the training of graduate students (total of 16, 6 of them MD/PhDs) and postdoctoral fellows (20), many of whom received fellowship awards, K99 grants, joined prestigious residency programs and became independent faculty. -
Scott G. Soltys, MD
Professor of Radiation Oncology (Radiation Therapy) and, by courtesy, of Neurosurgery
On Leave from 06/03/2024 To 08/16/2024Current Research and Scholarly InterestsMy clinical and research interests focus on the development of new radiation techniques involving stereotactic radiosurgery and radiotherapy for the treatment of malignant and benign tumors of the brain and spine, as well as functional disorders such as trigeminal neuralgia.
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Konstantina M. Stankovic, MD, PhD, FACS
Bertarelli Foundation Professor and Professor of Otolaryngology - Head & Neck Surgery (OHNS) and, by courtesy, of Neurosurgery
Current Research and Scholarly InterestsOur investigative efforts are organized along 3 research thrusts:
1. Vestibular schwannoma: uncovering mechanisms of sensorineural hearing loss (SNHL) and identifying better therapies;
2. High-resolution imaging of the inner ear;
3. Novel sensing of and therapies for SNHL.
Given the complex, multifaceted nature of these problems, our approach to them involves domain-specific customization and fusion of tools from molecular biology, systems neuroscience, biotechnology and otologic surgery. -
Gary K. Steinberg, MD, PhD
Bernard and Ronni Lacroute-William Randolph Hearst Professor of Neurosurgery and Neurosciences and Professor, by courtesy, of Neurology
Current Research and Scholarly InterestsOur laboratory investigates the pathophysiology and treatment of cerebral ischemia, and methods to restore neurologic function after stroke. Treatment strategies include brain hypothermia, stem cell transplantation and optogenetic stimulation. Our clinical research develops innovative surgical, endovascular and radiosurgical approaches for treating difficult intracranial aneurysms, complex vascular malformations and occlusive disease, including Moyamoya disease, as well as stem cell transplant.
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Thomas Sudhof
Avram Goldstein Professor in the School of Medicine, Professor of Neurosurgery and, by courtesy, of Neurology and of Psychiatry and Behavioral Sciences
Current Research and Scholarly InterestsInformation transfer at synapses mediates information processing in brain, and is impaired in many brain diseases. Thomas Südhof is interested in how synapses are formed, how presynaptic terminals release neurotransmitters at synapses, and how synapses become dysfunctional in diseases such as autism or Alzheimer's disease. To address these questions, Südhof's laboratory employs approaches ranging from biophysical studies to the electrophysiological and behavioral analyses of mutant mice.
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Peter Tass
Professor of Neurosurgery
BioDr. Peter Tass investigates and develops neuromodulation techniques for understanding and treating neurologic conditions such as Parkinson’s disease, epilepsy, dysfunction following stroke and tinnitus. He creates invasive and non-invasive therapeutic procedures by means of comprehensive computational neuroscience studies and advanced data analysis techniques. The computational neuroscience studies guide experiments that use clinical electrophysiology measures, such as high density EEG recordings and MRI imaging, and various outcome measures. He has pioneered a neuromodulation approach based on thorough computational modelling that employs dynamic self-organization, plasticity and other neuromodulation principles to produce sustained effects after stimulation. To investigate stimulation effects and disease-related brain activity, he focuses on the development of stimulation methods that cause a sustained neural desynchronization by an unlearning of abnormal synaptic interactions. He also performs and contributes to pre-clinical and clinical research in related areas.
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Nicholas Telischak, MD, MS
Clinical Associate Professor, Radiology
Clinical Associate Professor (By courtesy), NeurosurgeryBioA native of the Bay Area, Dr. Nick Telischak is a dual fellowship-trained neurointerventional surgeon and neuroradiologist at Stanford Health Care. With board certifications in radiology and neuroradiology, he serves as a clinical associate professor in the Department of Radiology, and, by courtesy of the Department of Neurosurgery, at Stanford School of Medicine.
Dr. Telischak specializes in diagnosing and treating artery disorders in the brain and spine, including brain aneurysms, arteriovenous malformations (AVM), and dural arteriovenous fistula (dAVF), and stroke. Dr. Telischak also specializes in venous disorders in the brain including idiopathic intracranial hypertension (IIH). He also has a special interest in pulsatile tinnitus, a whooshing sound in the ears that occurs in rhythm with the heartbeat. Dr. Telischak also treats painful spinal (vertebral) fractures, spinal metastases (tumors resulting from cancer elsewhere in the body), and congenital vascular malformations (blood vessel abnormalities that are present at birth). He treats these conditions using minimally invasive, image-guided procedures and state-of-the-art technology.
Prior to joining Stanford Health Care, Dr. Telischak helped develop the Stroke Program at California Pacific Medical Center and Mills-Peninsula Medical Center, giving him a broad perspective on medical care systems within the Bay Area.
Dr. Telischak’s research focuses on:
• Identifying biomarkers to diagnose large vessel occlusion stroke (stroke in one of the large arteries in the brain)
• Noninvasive MRI techniques for diagnosing idiopathic intracranial hypertension (high pressure within the skull)
He is also the principal investigator for a study examining the efficacy of vertebroplasty and kyphoplasty for the treatment of painful vertebral compression fractures.
In addition, Dr. Telischak holds a master’s degree in bioengineering. He has worked with several companies pioneering new devices to treat brain aneurysms, vascular malformations, and strokes caused by blood clots, as well as new treatments for venous disorders in the brain caused by idiopathic intracranial hypertension.
Dr. Telischak has published more than 20 peer-reviewed articles and has been invited to present locally, nationally, and internationally at meetings for the Society of NeuroInterventional Surgery, American Society of Neuroradiology, and Jornada de Stroke in Asuncion, Paraguay, where he has served as visiting faculty. -
Suzanne Tharin
Associate Professor of Neurosurgery
Current Research and Scholarly InterestsThe long-term goal of my research is the repair of damaged corticospinal circuitry. Therapeutic regeneration strategies will be informed by an understanding both of corticospinal motor neuron (CSMN) development and of events occurring in CSMN in the setting of spinal cord injury. MicroRNAs are small, non-coding RNAs that regulate the expression of “suites” of genes. The work in my lab seeks to identify microRNA controls over CSMN development and over the CSMN response to spinal cord injury.
