Stanford University
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Mohammad Shahrokh Esfahani
Assistant Professor of Radiation Oncology (Radiation and Cancer Biology)
BioI lead a computational oncology laboratory that develops machine learning and statistical methods for high-dimensional genomics, with particular expertise in Bayesian and uncertainty-aware modeling to integrate prior biological knowledge with large-scale datasets.
Our research centers on liquid biopsy analytics—especially cell-free DNA (cfDNA)—to noninvasively quantify genetic and epigenetic states relevant to cancer detection, monitoring, and tumor evolution. We developed EPIC-seq, a fragmentomics-based method that uses cfDNA fragmentation patterns to infer regulatory activity and gene expression programs, providing a scalable framework for epigenetic profiling from blood.
A core methodological focus of the lab is enabling reliable inference in extremely low signal-to-noise settings that are typical of cfDNA and early-stage disease. We build robust, interpretable models and benchmarking frameworks that support clinical translation, with the long-term aim of democratizing access to sensitive, minimally invasive cancer diagnostics. -
Mehrdad Shamloo
Professor (Research) of Neurosurgery and, by courtesy, of Neurology and Neurological Sciences
Current Research and Scholarly InterestsThe ultimate goal of the Shamloo laboratory is to rapidly advance our understanding of brain function at the molecular, cellular, circuit and behavioral levels, and to elucidate the pathological process underlying malfunction of the nervous system following injury and neurologic disorders such as stroke, Alzheimer's disease, Parkinson’s disease, and autism. We have been focusing on the noradrenergic system and approaches leading to restoration of brain adrenergic signaling in these disorders.
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Hua Shan
Professor of Pathology
BioDr. Shan specializes in providing blood transfusion and apheresis treatment to patients with diverse medical problems. She has been practicing transfusion medicine for over thirty years. Dr. Shan served as the Medical Director of Transfusion Service at Stanford Medical Center from 2015 to 2026. Dr. Shan has also been leading research and education programs in the fields of transfusion safety, optimizing clinical blood transfusion practice and blood availability.
