Stanford University
Showing 5,951-5,960 of 7,809 Results
-
maura ruzhnikov
Member, Maternal & Child Health Research Institute (MCHRI)
BioChild neurologist and medical geneticist focusing on the diagnosis and management of rare neurologic disorders. Specific interests are in genetic epilepsy syndromes, childhood neurodegenerative and neurometabolic diseases and undiagnosed suspected genetic conditions.
-
Katherine Jane Ryan
Clinical Assistant Professor, Pediatrics - Hematology & Oncology
Clinical Assistant Professor (By courtesy), Adult NeurologyCurrent Research and Scholarly InterestsDr. Katherine “Katie” Ryan is a pediatric neuro-oncologist whose research focuses on developing and translating cellular immunotherapies for children with malignant brain tumors. She leads the first-in-human trial of GPC2-directed CAR T cells for CNS Embryonal Tumors. As a member of Stanford Children’s world-renowned pediatric brain tumor team, she diagnoses and treats children with CNS tumors while advancing innovative trial design, intracerebroventricular delivery, and correlative science.
-
Tracy Rydel
Clinical Professor, Medicine - Primary Care and Population Health
BioTracy Rydel is Clinical Professor of Medicine at Stanford University School of Medicine where she holds the positions of Assistant Dean for Clerkship Education and Director, Core Clerkship in Family and Community Medicine. She has also served as the Director of Medical Student Education in the Division of Primary Care and Population Health, and was an Educator-4-CARE faculty from 2017-2020. She is a family physician with a passion for medical education. She completed the Rathmann Family Foundation Fellowship in Patient-centered Care and Medical Education in 2012, was in the first wave of peer coaches in the Peer Coaching Program under the Stanford Teaching and Mentoring Academy, and was the Director of the Practice of Medicine Year One Course at Stanford from 2013-2016. She emphasizes patient-centered care in the pursuit of clinical and educational excellence. She is frequently an invited presenter at the national conferences of the Society of Teachers of Family Medicine (STFM), and the Western Group on Educational Affairs (WGEA) regional group of the AAMC; her scholarly work focuses on medical education endeavors, including equity and justice in systems of medical education assessment. She has also presented and published on topics in nutrition education and the teaching kitchen, working with medical scribes, Entrustable Professional Activities, primary care career recruitment and mentoring, procedures training, time management in ambulatory teaching, communication skills, virtual health and telehealth, teaching gender-affirming primary care, and learning communities.
-
Raya Saab
Lindhard Family Professor of Pediatric Cancer Biology
BioI am a pediatric oncologist, and I primarily treat children who are diagnosed with soft tissue sarcomas including rhabdomyosarcoma, and children diagnosed with the eye tumor retinoblastoma, as well as children with other solid tumors.
I have two very different areas of primary research interest, both of which I pursue with passion. One focuses on global oncology, including clinical and research resource capacity building towards effective treatment and improving outcomes of children with cancer worldwide. I work with collaborators across the globe towards a common goal of improving access to diagnostic and clinical care, training of multidisciplinary teams, and building clinical resources and research capacity to develop context-informed approaches to improving cancer care and achieving better outcomes for children diagnosed with cancer irrespective of where they happen to live.
My parallel research interest, which is the focus of my laboratory, is understanding oncogenic signaling in pediatric soft tissue sarcomas, in an effort to clarify the driving biology and determinants of metastatic disease, to uncover novel targets for more effective treatment. We use preclinical in vitro and in vivo models, including murine and human cell lines, and mouse models of cancer. We have recently uncovered a paracrine role for rhabdomyosarcoma-secreted exosomes in impacting biology of stromal cells. Rhabdomyosarcoma-derived exosomes carry specific miRNA cargo that imparts an invasive and migratory phenotype on normal recipient fibroblasts, and proteomic analysis revealed specific and unique pathways relevant to the two different molecular rhabdomyosarcoma subtypes that are driven by distinct oncogenic pathways. We identified that the driver oncogene in fusion-positive rhabdomyosarcoma, PAX3-FOXO1, modulates exosome cargo to promote invasion, migration, and angiogenic properties, and identified specific microRNA and protein cargo acting as effectors of PAX3-FOXO1 exosome-mediated signaling, including modulation of oxidative stress response and cell survival signaling. Our ongoing work is focused on interrogating specific paracrine signaling pathways and molecular mechanisms of metastatic disease progression in rhabdomyosarcoma, for potential therapeutic targeting.
