Stanford University
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Shiva Pathak
Postdoctoral Scholar, Bone Marrow Transplantation
BioMy research interest is to develop tolerance-inducing strategies aimed at treating autoimmune diseases with a focus on type 1 diabetes (T1D). My exploration into T1D began with the design of novel drug delivery systems for immunosuppression in islet transplantation. This effort enabled the formulation of an effective immunosuppression protocol, which resulted in prolonged survival of transplanted islets in murine models. Recently, I have pivoted towards inducing tolerance via mixed donor chimerism, which has demonstrated promise in augmenting islet survival by mitigating autoimmune responses in T1D. A key goal of my research is to reduce the dosage of immunosuppressive therapies while leveraging T regulatory cells (Tregs) to facilitate antigen-specific tolerance. I am investigating the potential application of TCR-engineered Tregs and chimeric antigen receptor (CAR) Tregs to foster tolerance in both T1D and islet transplantation contexts. Additionally, I have been examining the functional roles of distinct Treg subsets in peripheral tolerance within non-obese diabetic chimeras, with the intent that elucidating the mechanisms underlying Treg-mediated suppression will inform the development of novel tolerance induction pathways for T1D.