Stanford University
Showing 11-20 of 94 Results
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Alan C. Pao
Associate Professor of Medicine (Nephrology) and, by courtesy, of Urology
Current Research and Scholarly InterestsWe are broadly interested in how the kidneys control salt, water, and electrolyte homeostasis in the body. Our disease focus is on kidney stone disease. We use cultured kidney cells, transgenic mice, human plasma/urine samples, and electronic health record data to study the pathogenesis of kidney stone disease. Our therapeutic focus is on the development of small molecule compounds that can be used for kidney stone prevention.
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Peter Parham
Professor of Structural Biology and, by courtesy, of Microbiology and Immunology
Current Research and Scholarly InterestsThe Parham laboratory investigates the biology, genetics, and evolution of MHC class I molecules and NK cell receptors.
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Victoria Parikh
Assistant Professor of Medicine (Cardiovascular Medicine)
BioDr. Parikh is a clinician scientist who cares for patients with and studies inherited (genetic) cardiovascular disease. She is the director of the Stanford Center for Inherited Cardiovascular Disease (SCICD) which is one of the largest of its kind in the country. SCICD integrates clinical and basic science with the expert care of patients with genetic cardiovascular conditions (e.g., cardiomyopathies, arrhythmias and vascular diseases). It provides cutting edge care for thousands of patients and families across the lifespan and integrates medical, surgical and genetics care. Our team includes physicians, nurses, advanced practice providers, genetic counselors, exercise physiologists and scientists.
Dr. Parikh's own clinical practice and laboratory are focused on the genetics of cardiomyopathies and their associated arrhythmogenic substrates. She completed clinical cardiology fellowship at Stanford School of Medicine and her medical residency at the University of California, San Francisco. Funded by multiple research grants from the NIH, her lab seeks to identify novel mechanisms and therapeutic technologies for genetic cardiomyopathy as well as better understand the natural histories of patients affected by these diseases. -
David Jaehyun Park
Clinical Instructor, Neurosurgery
BioDavid Park, MD, PhD, is a neurosurgeon who graduated from medical school at the Catholic University of Korea in Seoul, South Korea. He then completed his internship and residency training in the Department of Neurosurgery at Seoul St. Mary’s Hospital. He became a board-certified neurosurgeon in South Korea in 2014 and subsequently completed a 2-year fellowship at the same hospital, specializing in brain tumor surgery and skull base surgery. During his residency, he also attended graduate school while practicing neurosurgery as a trainee and successfully defended his Ph.D. thesis, titled “Combination therapy for gliomas using temozolomide and interferon-beta secreting human bone marrow-derived mesenchymal stem cells,” in 2015.
After completing his fellowship in South Korea, Dr. Park moved to Singapore in 2016 and worked as a Clinical Fellow (Clinical Associate) at the National Neuroscience Institute for one year, focusing on Neurosurgical Oncology and Skull Base Surgery.
In 2017, Dr. Park joined Dr. Christian Badr’s lab at Massachusetts General Hospital, Harvard Medical School, as a Postdoctoral Research Fellow, conducting translational research on glioblastoma and studying the role of fatty acids and lipid metabolism in glioblastoma to complement his clinical expertise.
During this time, Dr. Park also launched a startup based on his invention of an intraoperative diagnostic tool for tumor detection during glioma surgery. He collaborated with bioengineers at M.I.T. to develop a prototype and secured seed funding from the MIT Sandbox Innovation Fund Program. As an alumnus of the MIT Sandbox program, he continues to develop this project.
In 2020, Dr. Park served as a Neurosurgical Oncology and Radiosurgery Fellow (Teaching Associate) for a year at North Shore University Hospital, Zucker School of Medicine at Hofstra/Northwell, in Long Island, New York, where he worked with Dr. Michael Schulder on brain tumor surgery including advanced techniques, such as Laser Interstitial Thermal Therapy (LITT) and Stereotactic Radiosurgery (SRS).
From July 2021 to June 2022, he completed another fellowship in Neurosurgical Oncology and Radiosurgery at the Cleveland Clinic in Cleveland. He devoted his efforts to minimally invasive neurosurgical techniques such as LITT and Gamma Knife SRS, as well as awake brain tumor surgery under the guidance of Drs. Gene Barnett, Lilyana Angelov, and Ali Mohammadi.
As of July 2022, Dr. Park has joined the Department of Neurosurgery at Stanford University as a Clinical Instructor, working with Dr. Steven D. Chang in the fields of Neurosurgical Oncology and CyberKnife SRS. -
Jon Park, MD, FRCSC
Saunders Family Professor
Current Research and Scholarly InterestsNon-fusion dynamic spinal stabilization, artificial disc technologies, and regenerative spinal technologies.
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Karen J. Parker, PhD
Truong-Tan Broadcom Endowed Professor and Professor, by courtesy, of Comparative Medicine
Current Research and Scholarly InterestsThe Parker Lab conducts research on the biology of social functioning in monkeys, typically developing humans, and patients with social impairments.
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Vanessa Parli
Director of Research Programs, Institute for Human-Centered Artificial Intelligence (HAI)
BioVanessa Parli is the Director of Research at HAI. She leads the HAI grant programs, research convenings, student groups and “state of AI” reports such as the AI 100 and the AI Index where she is a member of the Steering Committee. Her team also analyzes the effectiveness of these programs to continuously improve HAI’s ability to foster interdisciplinary research collaborations internal and external to Stanford. Prior to Stanford, Vanessa worked in management consulting where she utilized statistics, machine learning and other data science methodologies to advise government agencies, large biotech companies and nonprofit organizations. Vanessa holds an MS in Engineering Management and Computational Mathematics from Johns Hopkins University and a BA in Industrial Engineering from Arizona State University.
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Josef Parvizi, MD, PhD
Professor of Neurology (Adult Neurology) and, by courtesy, of Neurosurgery
BioDr. Parvizi completed his medical internship at Mayo Clinic, neurology training at Harvard, and subspecialty training in clinical neurophysiology and epilepsy at UCLA before joining the Department of Neurology and Neurological Sciences at Stanford in 2007. Dr. Parvizi directs the Stanford Program for Medication Resistant Epilepsies and specializes in surgical treatments of intractable focal epilepsies. Dr. Parvizi is the principal investigator in the Laboratory of Behavioral and Cognitive Neuroscience, where he leads a team of investigators to study the human brain. http://med.stanford.edu/parvizi-lab.html.
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Anca M. Pasca, MD
Assistant Professor of Pediatrics
Current Research and Scholarly InterestsThe research focus of the lab is to understand molecular mechanisms underlying neurodevelopmental disorders associated with premature birth, neonatal and fetal brain injury with the long-term goal of translating the lab’s findings into therapeutics. The research team employs a multidisciplinary approach involving genetics, molecular and developmental neurobiology, animal models and neural cells differentiated from patient-derived induced pluripotent stem (iPS) cells. In particular, the lab is using a powerful 3D human brain-region specific organoid system developed at Stanford (Nature Methods, 2015; Nature Protocols, 2018) to ask questions about brain injury during development.
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Sergiu P. Pasca
Kenneth T. Norris, Jr. Professor of Psychiatry and Behavioral Sciences and Bonnie Uytengsu and Family Director of the Stanford Brain Organogenesis Program
Current Research and Scholarly InterestsA critical challenge in understanding the intricate programs underlying development, assembly and dysfunction of the human brain is the lack of direct access to intact, functioning human brain tissue for detailed investigation by imaging, recording, and stimulation.
To address this, we are developing bottom-up approaches to generate and assemble, from multi-cellular components, human neural circuits in vitro and in vivo.
We introduced the use of instructive signals for deriving from human pluripotent stem cells self-organizing 3D cellular structures named brain region-specific spheroids/organoids. We demonstrated that these cultures, such as the ones resembling the cerebral cortex, can be reliably derived across many lines and experiments, contain synaptically connected neurons and non-reactive astrocytes, and can be used to gain mechanistic insights into genetic and environmental brain disorders. Moreover, when maintained as long-term cultures, they recapitulate an intrinsic program of maturation that progresses towards postnatal stages.
We also pioneered a modular system to integrate 3D brain region-specific organoids and study human neuronal migration and neural circuit formation in functional preparations that we named assembloids. We have actively applied these models in combination with studies in long-term ex vivo brain preparations to acquire a deeper understanding of human physiology, evolution and disease mechanisms.
We have carved a unique research program that combines rigorous in vivo and in vitro neuroscience, stem cell and molecular biology approaches to construct and deconstruct previously inaccessible stages of human brain development and function in health and disease.
We believe science is a community effort, and accordingly, we have been advancing the field by broadly and openly sharing our technologies with numerous laboratories around the world and organizing the primary research conference and the training courses in the area of cellular models of the human brain.