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Neetu Saini

Postdoctoral Scholar, Stem Cell Transplantation

BioMy research interests focus on translational human T-cell immunology, with an emphasis on regulatory T cells (Tregs) and their therapeutic potential in restoring immune tolerance and tissue homeostasis. I am particularly interested in engineering FOXP3-programmed CD4⁺ T cells as a stable and functional alternative to conventional Tregs, especially in inflammatory settings where endogenous Tregs may be unstable or dysfunctional. My work integrates gene-editing approaches, immunophenotyping, and human organoid systems to study how these engineered cells interact with epithelial and stem cell compartments, with a focus on mechanisms of tissue repair and immune–epithelial crosstalk in barrier tissues such as the intestine. Moving forward, I aim to advance next-generation cell therapies by combining insights from T-cell biology, tissue biology, and disease modeling to develop durable and clinically relevant strategies for treating immune-mediated and epithelial barrier disorders.