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Current Research and Scholarly InterestsOur research focuses on unraveling the molecular mechanisms underlying retinal development and diseases. We employ genetic and genomic tools to explore how various retinal cell types, including neurons, glia, and the vasculature, respond to developmental cues and disease insults at the epigenomic and transcriptional levels. In addition, we investigate their interactions and collective contributions to maintain retinal integrity.

1. Investigating retinal development:
We utilize genetic tools and methods such as in vivo plasmid electroporation and CRISPR to dissect the roles of cis-regulatory elements and transcription factors in controlling retinal development.

2. Understanding diabetes-induced cell-type-specific responses in the retina:
Diabetes triggers a range of multicellular responses in the retina, such as vascular lesions, glial dysfunction, and neurodegeneration, all of which contribute to retinopathy. We delve into the detailed molecular mechanisms underlying these diabetes-induced cell-type-specific responses and the pathogenesis of diabetic retinopathy.

3. Developing molecular tools for labeling and manipulation of specific cell types in vivo:
Cis-regulatory elements, particularly enhancers, play pivotal roles in directing tissue- and cell-type-specific expression. Our interest lies in identifying enhancers that can drive cell type-specific expression in the retina and brain. We incorporate these enhancers into plasmid or AAV-based delivery systems, enabling precise labeling and manipulation of specific cell types in vivo.

Sydney Wang

Undergraduate, Vice Provost for Undergraduate Education

Contact Info
swang29@stanford.edu

Taia T. Wang, MD, PhD, MSCI

Associate Professor of Medicine (Infectious Diseases) and of Microbiology and Immunology

Current Research and Scholarly InterestsLaboratory of Mechanisms in Human Immunity and Disease Pathogenesis

Tammy Wang

Clinical Associate Professor, Anesthesiology, Perioperative and Pain Medicine

Tao Wang (王韬)

Director of Precision Diabetes Care, Genetics

Current Role at StanfordPrincipal Investigator, AI for Precision Diabetes Management
Project Manager & Scientific Co-lead, PsychENCODE Project
Project Initiator & Clinical Co-lead, Long COVID Clinical RCT with TCM
Project Initiator & Manager, AI & Wearables Toolkit for Biomedical Sciences
ENCODE and PsychENCODE Project Data Manager
Research Scientist, US Veteran Affairs Hospital
SCGPM HPC System Administrator