Stanford University
Showing 41-50 of 70 Results
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Grace Xiong, MD
Assistant Professor of Orthopaedic Surgery
BioDr. Grace Xiong is an Assistant Professor and the Patient Safety Director for the Department of Orthopaedic Surgery at Stanford Health Care. She completed her undergraduate education at Harvard College and her medical education at Stanford University. She completed residency in orthopaedic surgery (Harvard Medical School) where she was a chief resident and trained under orthopaedic leaders at Massachusetts General Hospital, Brigham and Women’s Hospital, Beth Israel Deaconess Hospital, and Boston Children’s Hospital. This was followed by a fellowship in spinal surgery at the Rothman Orthopaedic Institute and Jefferson University under the tutelage of world-renowned mentors including Drs. Alexander Vaccaro, Alan Hilibrand, and Christopher Kepler.
Dr. Xiong’s expertise spans the full spectrum of spinal disorders. This includes degenerative cervical, thoracic, and lumbar conditions, particularly spinal disc herniations, spinal stenosis, spinal cysts, spondylolisthesis, and spondylosis causing radiculopathy, myelopathy, claudication, and sciatica. She specializes in both minimally invasive and complex reconstructive and revision spinal surgery. She is particularly interested in the use of motion-preserving approaches to restore function, accelerate recovery, and decrease the need for future spinal surgery for patients. She was awarded the William H. Thomas award for excellence and collegiality in patient care. Patients choose Dr. Xiong for her thoughtful approach in diagnosis and careful use of surgery only when necessary.
Nationally, Dr. Xiong serves as the Associate Editor for leading medical journals in spine care including Spine and Spine Open. She also serves as the Chair of the Resident and Fellow Education Committee for the North American Spine Society and is a member of the Adult Spine Evaluation Committee for the American Academy of Orthopaedic Surgeons.
Dr. Xiong’s main research interests stem from her careful observations of clinical gaps facing patients with spinal issues. She has over 50 peer-reviewed medical publications. Her research focuses on improving the diagnosis and treatment of patients with chronic spinal cord injury, improving clinical outcomes in spinal surgery, and improving health access and equity to spinal care. She is a member of the AO Knowledge Forum, an international research consortium of spine surgeons aimed at improving care for patients with spinal trauma or spinal infections. She is also a member of the North American Spine Society, the American Academy of Orthopaedic Surgeons, the Cervical Spine Research Society, and is an Emerging Leader of the American Orthopaedic Association. -
熊剑 (Jian Xiong)
Postdoctoral Scholar, Chemical Engineering
BioI thrive to understand the roles of lysosomes in physiological and pathological conditions. Lysosomes are both degradation compartment and metabolic controlling hub, and dysregulation of lysosomal functions are frequently implicated in a vast number of diseases including neurodegenerative diseases, however, the systematic knowledge of the molecular mechanism by which lysosomal contributes to these diseases is lacking. Ion channels are the primary mediators of neuronal activity, defects in neuronal ion channel activity are linked with many kinds of neurodegenerative diseases. Interestingly, besides typical ion channels that are involved in the neuronal activity, defects in lysosomal ion channels, such as TRPML1, CLN7 and CLC-7 are also implicated in neuropathy. My previous work as Ph.D student in University of Texas MD Anderson Cancer Center focused on regulation of lysosomal function by ion channels and metabolites. I discovered a mechanism of lysosomal Na+ channel regulate mTORC1 activation by regulating lysosomal amino acid accumulation. I also discovered role of glutamine in controlling lysosomal degradation capacity. In the meantime, I developed novel methods to isolate organelles. My ultimate research goal is to understand the key developmental pathways and how alterations in gene sequences and expression contribute to human disease, therefore, I am pursuing independent academic researcher as my career goal. Starting Feb 2022, I work with Dr. Monther Abu-Remaileh at Stanford University on role of lysosomes in neurodegenerative diseases. I use genetics, chemical biology and omics approaches to study lysosome function under various physiological and pathological conditions, especially age-associated neurodegenerative disorders, and monogenic neurodegenerative lysosome storage diseases. In Stanford, I aim to integrate ionic regulation, metabolomic regulation and functional proteomic regulation to systematically understand the biology of lysosome in physiological conditions and pathological conditions.
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Lei Xiong
Postdoctoral Scholar, Genetics
Current Research and Scholarly InterestsMy research focuses on develop deep learning methods to
1. Infer macrophage-tumor cells interaction using spatial multi-omics
2. Decipher the cis-regulatory code using a large language models
3. Predict enhancer-promoter interaction
4. Multi-omics integration
5. Build foundational model for single-cell genomics
