Stanford University
Showing 1,021-1,030 of 1,066 Results
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Joy Wu
Professor of Medicine (Endocrinology)
Current Research and Scholarly InterestsMy laboratory focuses on the pathways that regulate the differentiation of mesenchymal stem cells into the osteoblast and adipocyte lineages. We are also studying the role of osteoblasts in the hematopoietic and cancer niches in the bone marrow microenvironment.
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Sean M. Wu
Professor of Medicine (Cardiovascular Medicine) and, by courtesy, of Pediatrics
Current Research and Scholarly InterestsMy lab seeks to identify mechanisms regulating cardiac lineage commitment during embryonic development and the biology of cardiac progenitor cells in development and disease. We believe that by understanding the transcriptional and epigenetic basis of cardiomyocyte growth and differentiation, we can identify the most effective ways to repair diseased adult hearts. We employ mouse and human embryonic and induced pluripotent stem cells as well as rodents as our in vivo models for investigation.
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Courtney Wusthoff, MD
Professor of Neurology (Pediatric Neurology) and, by courtesy, of Pediatrics (Neonatology)
Current Research and Scholarly InterestsMy projects focus on clinical research in newborns with, or at risk, for brain injury. I use EEG in at-risk neonates to better understand the underlying pathophysiology of risk factors that may lead to worse outcomes. I am particularly interested in neonatal seizures and how they may exacerbate perinatal brain injury with a goal to identify treatments that might protect the vulnerable brain. I am also interested in EEG in other pediatric populations, as well as medical ethics and global health.
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Tony Wyss-Coray, PhD
D. H. Chen Professor II
Current Research and Scholarly InterestsUse of genetic and molecular tools to dissect immune and inflammatory pathways in Alzheimer's and neurodegeneration.
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Jian Xiong
Postdoctoral Scholar, Chemical Engineering
BioI thrive to understand the roles of lysosomes in physiological and pathological conditions. Lysosomes are both degradation compartment and metabolic controlling hub, and dysregulation of lysosomal functions are frequently implicated in a vast number of diseases including neurodegenerative diseases, however, the systematic knowledge of the molecular mechanism by which lysosomal contributes to these diseases is lacking. Ion channels are the primary mediators of neuronal activity, defects in neuronal ion channel activity are linked with many kinds of neurodegenerative diseases. Interestingly, besides typical ion channels that are involved in the neuronal activity, defects in lysosomal ion channels, such as TRPML1, CLN7 and CLC-7 are also implicated in neuropathy. My previous work as Ph.D student in University of Texas MD Anderson Cancer Center focused on regulation of lysosomal function by ion channels and metabolites. I discovered a mechanism of lysosomal Na+ channel regulate mTORC1 activation by regulating lysosomal amino acid accumulation. I also discovered role of glutamine in controlling lysosomal degradation capacity. In the meantime, I developed novel methods to isolate organelles. My ultimate research goal is to understand the key developmental pathways and how alterations in gene sequences and expression contribute to human disease, therefore, I am pursuing independent academic researcher as my career goal. Starting Feb 2022, I work with Dr. Monther Abu-Remaileh at Stanford University on role of lysosomes in neurodegenerative diseases. I use genetics, chemical biology and omics approaches to study lysosome function under various physiological and pathological conditions, especially age-associated neurodegenerative disorders, and monogenic neurodegenerative lysosome storage diseases. In Stanford, I aim to integrate ionic regulation, metabolomic regulation and functional proteomic regulation to systematically understand the biology of lysosome in physiological conditions and pathological conditions.
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Hao Yan
Postdoctoral Scholar, Bone Marrow Transplantation
BioAs a highly motivated researcher with a passion for conducting basic research that has direct implications for patient care, I have completed my Ph.D. training in physiology in China and pursued postdoctoral training in the United States. My academic training and research experience have provided me with an excellent background in multiple biological disciplines including developmental biology, gerontology, immunology, and pre-clinic research. As a doctoral student with Dr. Guoliang Xia, I focused on mammalian ovary development and aging with the goal of improving the in-vitro fertilization process for cancer patients and women over 40, and aimed to uncover the mechanisms that control the non-renewable oocyte activation and slow down its quantity and quality loss during aging.
During my Ph.D. training, I became interested in immunology research, inspired by my involvement in a project on maternal-fetal immunotolerance. In naturally conceived pregnancies, the fetus is semi-allogeneic to the mother, and the maternal immune system is exposed to foreign HLA antigens from the child. However, the fetus is well-tolerated within a specific time window. As a postdoctoral fellow at Stanford University, I joined the lab of Dr. Robert Negrin, a renowned leader in the bone marrow transplantation (BMT)/GVHD field, to explore immunotolerance-related issues such as graft-versus-host disease and blood malignancies.
