Stanford University
Showing 561-570 of 1,261 Results
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Chaitan Khosla
Wells H. Rauser and Harold M. Petiprin Professor and Professor of Chemistry and, by courtesy, of Biochemistry
Current Research and Scholarly InterestsResearch in this laboratory focuses on problems where deep insights into enzymology and metabolism can be harnessed to improve human health.
For the past two decades, we have studied and engineered enzymatic assembly lines called polyketide synthases that catalyze the biosynthesis of structurally complex and medicinally fascinating antibiotics in bacteria. An example of such an assembly line is found in the erythromycin biosynthetic pathway. Our current focus is on understanding the structure and mechanism of this polyketide synthase. At the same time, we are developing methods to decode the vast and growing number of orphan polyketide assembly lines in the sequence databases.
For more than a decade, we have also investigated the pathogenesis of celiac disease, an autoimmune disorder of the small intestine, with the goal of discovering therapies and related management tools for this widespread but overlooked disease. Ongoing efforts focus on understanding the pivotal role of transglutaminase 2 in triggering the inflammatory response to dietary gluten in the celiac intestine. -
Grace S. Kim, MD
Assistant Professor of Otolaryngology - Head & Neck Surgery (OHNS)
BioGrace S. Kim, MD is a pediatric otolaryngologist and surgeon-scientist in the Department of Otolaryngology–Head & Neck Surgery at Stanford University. Her clinical practice focuses on the full spectrum of pediatric otolaryngology, with particular expertise in hearing loss, chronic ear disease, thyroid disorders, vascular malformations and pediatric head and neck conditions. Her research investigates the immune mechanisms underlying congenital hearing loss and inner ear injury, with the goal of developing therapies to preserve hearing in children.
Dr. Kim received her BA in Biochemical Sciences from Harvard University and her MD from Stanford University School of Medicine, where she also completed an additional year of research as a Howard Hughes Medical Institute Research Fellow. She completed residency training in otolaryngology–head and neck surgery at Stanford, including a two-year NIH-sponsored research fellowship investigating vestibular repair and regeneration, followed by fellowship training in complex pediatric otolaryngology at Stanford.
Dr. Kim joined the Stanford faculty in 2023. She leads a translational research program investigating inner ear neuroimmunology and congenital hearing loss, using animal models to understand how congenital cytomegalovirus infection and immune responses impact the developing auditory system. Her long-term goal is to develop targeted therapies that prevent hearing loss in children. Her work is supported by an NIH Mentored Clinical Scientist Research Career Development (K08) Award, as well as funding from the American Society of Pediatric Otolaryngology and the Stanford Maternal & Child Health Research Institute. -
Peter S. Kim
Virginia and D. K. Ludwig Professor of Biochemistry
Current Research and Scholarly InterestsOur research focuses on developing new strategies for vaccine creation. We also aim to generate vaccines targeting infectious agents that have eluded efforts to date. We integrate experimental approaches with protein language models to guide artificial evolution and enable efficient antibody and protein engineering. Our interdisciplinary approach aims to address critical global health challenges.
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Seung K. Kim M.D., Ph.D.
KM Mulberry Professor, Professor of Developmental Biology, of Medicine (Endocrinology) and, by courtesy, of Pediatrics (Endocrinology)
Current Research and Scholarly InterestsPancreatic islets are essential for human health. We study the development and function of islet cells using modern methods in several model systems, including mice, pigs, human pancreas, primates, embryonic stem cells, and fruit flies. We have discovered critical factors required for islet development and mature islet cell function. These approaches have informed efforts to generate replacement islets, and provide immune protection of transplanted islets for diabetes.
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Yong Yean Kim
Assistant Professor of Pediatrics ( Hematology & Oncology)
BioOur lab is interested in translational science to bring new therapies to clinical trials. In particular, we are interested in pediatric sarcomas which have not had advancement in clinical treatment for decades. Current projects in the lab focus on understanding of the biology of fusion transcription factor PAX3::FOXO1 which is the driver mutation in fusion positive rhabdomyosarcoma. PAX3::FOXO1 is a powerful oncogenic transcription factor which rewires the transcriptional organization to lock the cancer cell in the proliferative state. Since transcription factors including PAX3::FOXO1 are difficult to target using small molecules, we aim to understand how PAX3::FOXO1 is regulated and targeting the regulators of PAX3::FOXO1. By understanding and targeting the regulation of PAX3::FOXO1, we hope to bring new therapies for fusion positive rhabdomyosarcoma. Additionally, these regulatory mechanisms may also be active in other transcription driven cancers such as the EWSR1::FLI1 driven Ewings Sarcoma.
Our lab is also interested in exploring the epigenetic landscape of pediatric solid tumors and trying to understand how dysregulation in the epigenome drives oncogenesis. We utilize various CRISPR mediated genetic techniques to interrogate the regulators of epigenome focusing on the histone lysine demethylases (KDMs). KDMs are an understudied group of epigenetic regulators which can be targeted for therapeutic effect. We explore the role of KDMs in pediatric solid tumors and hope to identify potential targets for drug development.
