Stanford University
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Madison George
Ph.D. Student in Bioengineering, admitted Autumn 2023
Current Research and Scholarly InterestsExertional compartment syndrome (ECS) is a painful condition characterized by abnormally high muscle compartment pressures induced by exercise. The diagnostic procedure for ECS requires the insertion of a needle into the muscle to directly quantify pressure, which is a barrier to both patients and clinicians. We will develop and evaluate new MRI technologies to (1) increase understanding of the pathophysiology of this condition and (2) Improve clinical diagnosis of ECS.
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Paul George, MD, PhD
Associate Professor of Neurology and Neurological Sciences (Adult Neurology) and, by courtesy, of Neurosurgery
Current Research and Scholarly InterestsCONDUCTIVE POLYMER SCAFFOLDS FOR STEM CELL-ENHANCED STROKE RECOVERY:
We focus on developing conductive polymers for stem cell applications. We have created a microfabricated, polymeric system that can continuously interact with its biological environment. This interactive polymer platform allows modifications of the recovery environment to determine essential repair mechanisms. Recent work studies the effect of electrical stimulation on neural stem cells seeded on the conductive scaffold and the pathways by which it enhances stroke recovery Further understanding the combined effect of electrical stimulation and stem cells in augmenting neural repair for clinical translational is a major focus of this research going forward.
BIOPOLYMER SYSTEMS FOR NEURAL RECOVERY AND STEM CELL MODULATION:
The George lab develops biomaterials to improve neural recovery in the peripheral and central nervous systems. By controlled release of drugs and molecules through biomaterials we can study the temporal effect of these neurotrophic factors on neural recovery and engineer drug delivery systems to enhance regenerative effects. By identifying the critical mechanisms for stroke and neural recovery, we are able to develop polymeric technologies for clinical translation in nerve regeneration and stroke recovery. Recent work utilizing these novel conductive polymers to differentiate stem cells for therapeutic and drug discovery applications.
APPLYING ENGINEERING TECHNIQUES TO DETERMINE BIOMARKERS FOR STROKE DIAGNOSTICS:
The ability to create diagnostic assays and techniques enables us to understand biological systems more completely and improve clinical management. Previous work utilized mass spectroscopy proteomics to find a simple serum biomarker for TIAs (a warning sign of stroke). Our study discovered a novel candidate marker, platelet basic protein. Current studies are underway to identify further candidate biomarkers using transcriptome analysis. More accurate diagnosis will allow for aggressive therapies to prevent subsequent strokes. -
Rachel Ann George
Lecturer
BioRachel George is a Lecturer in International Relations. She is also Nonresident Scholar with the Carnegie Endowment for International Peace and Research Fellow with the Georgetown Institute for Women, Peace and Security.
Dr. George's research focuses on foreign policy, democracy, Middle East politics, international law, women, peace, and security, AI and other emerging technologies, and the connections between development and international security. She has been published in a range of outlets, including in Foreign Policy, Just Security, The Washington Quarterly, World Politics Review, The National Interest, Think Global Health, CFR.org, Human Rights Review, and as chapters in The Arab Gulf States and the West: Perception and Misperception, Opportunities and Perils, and The Routledge History of Human Rights.
At Stanford, she leads the Diplomacy Lab and the Research Capstone Paper course within the Program in International Relations. She holds a BA in Politics and French from Princeton University, an MA in Middle East Studies from Harvard University, and PhD in International Relations from the London School of Economics & Political Science.
Website: https://www.rachelanngeorge.com/
