Stanford University
Showing 34,361-34,380 of 37,040 Results
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Irving Weissman
Virginia & D.K. Ludwig Professor of Clinical Investigation in Cancer Research, Professor of Pathology, and of Developmental Biology
Current Research and Scholarly InterestsStem cell and cancer stem cell biology; development of T and B lymphocytes; cell-surface receptors for oncornaviruses in leukemia. Hematopoietic stem cells; Lymphocyte homing, lymphoma invasiveness and metastasis; order of events from hematopoietic stem cells [HSC] to AML leukemia stem cells and blood diseases, and parallels in other tissues; discovery of tumor and pathogenic cell 'don't eat me' and 'eat me' signals, and translation into therapeutics.
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Itschak Weissman
Robert and Barbara Kleist Professor in the School of Engineering
BioTsachy's research focuses on Information Theory, Data Compression and Communications, Statistical Signal Processing, Machine Learning, the interplay between them, and their applications, with recent focus on applications to genomic data compression and processing. He is inventor of several patents and involved in several companies as member of the technical board. IEEE fellow, he serves on the board of governors of the information theory society as well as the editorial boards of the Transactions on Information Theory and Foundations and Trends in Communications and Information Theory. He is founding Director of the Stanford Compression Forum.
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Paul B. Welander
Lead Scientist, SLAC National Accelerator Laboratory
BioPaul Welander is a Lead Scientist and Head of the Quantum Devices Department in the Technology Innovation Directorate at SLAC National Accelerator Laboratory. Paul’s research interests concern materials for quantum devices, from the study of materials-induced decoherence mechanisms in superconducting quantum bits, to the development of materials platforms that enable novel quantum technologies. He’s a researcher in both the Detector Microfabrication Facility and Nano-X, two new state-of-the-art cleanrooms at SLAC geared toward superconductor quantum device fabrication and rapid nano-prototyping, respectively. Paul also leads experiments at the Stanford Synchrotron Radiation Lightsource (SSRL) to characterize materials used in superconducting quantum devices and correlate those measurements with device performance and quantum decoherence rates. His expertise includes molecular beam epitaxy of metal-oxide heterostructures, superconducting device fabrication, and an array of materials characterization techniques including electron and x-ray diffraction, photoelectron spectroscopy, and scanning probe microscopy. Paul received his Ph.D. in physics from the University of Illinois at Urbana-Champaign, and holds Bachelors degrees from both Caltech and Occidental College. Prior to joining SLAC in 2012, he spent five years as a member of the technical staff at MIT Lincoln Laboratory.
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Paula V. Welander
Associate Dean for Research and Professor of Earth System Science
Current Research and Scholarly InterestsBiosynthesis of lipid biomarkers in modern microbes; molecular geomicrobiology; microbial physiology
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Chad S. Weldy, M.D., Ph.D.
Instructor, Medicine - Cardiovascular Medicine
Current Research and Scholarly InterestsAs a physician-scientist I work to understand the genetic basis of cardiovascular disease and the transcriptional and epigenomic mechanisms of atherosclerosis. My work is focused across four main areas of cardiovascular genetics and mechanisms of coronary artery disease and smooth muscle biology:
1.Vascular smooth muscle specific ADAR1 mediated RNA editing of double stranded RNA and activation of the double stranded RNA receptor MDA5 in coronary artery disease and vascular calcification
2.Defining on single cell resolution the cellular and epigenomic features of human vascular disease across vascular beds of differing embryonic origin
3.CRISPRi screening with targeted perturb seq (TAPseq) to identify novel CAD genes in human coronary artery smooth muscle cells
4.Investigation of the epigenetic and molecular basis of coronary artery disease and smooth muscle cell transition in mice with conditional smooth muscle genetic deletion of CAD genes Pdgfd and Sox9
My work is focused on discovery of causal mechanisms of disease through leveraging human genetics with sophisticated molecular biology, single cell sequencing technologies, and mouse models of disease. This work attempts to apply multiple scientific research arms to ultimately lead to novel understandings of vascular disease and discover important new therapeutic approaches for drug discovery.
First Author Manuscripts for this work:
•Weldy, C. S., et al. (2025). Smooth muscle cell expression of RNA editing enzyme ADAR1 controls activation of RNA sensor MDA5 in atherosclerosis. (2025). Nature Cardiovascular Research. 1-17, PMID: 40958051, doi: 10.1038/s44161-025-00710-5
•*Selected as finalist for Louis N. and Arnold M. Katz Basic Science Research Prize from the American Heart Association, finalist competition November 16, 2024, Chicago
•Work was highlighted in the Stanford Department of Medicine News
https://medicine.stanford.edu/news/current-news/standard-news/RNA-editing.html
•Weldy, C.S., et al. (2025). Epigenomic landscape of single vascular cells reflects developmental origin and disease risk loci. Molecular Systems Biology. 1-25, PMID: 40931195, doi:10.1038/s44320-025-00140-2.
•*Selected for the cover of November 2025 edition of Molecular Systems Biology
Grant funding received for this work:
Mentored Clinical Scientist Research Career Development Award (K08)(NIH/NHLBI, 1 K08 HL167699-01), August, 2023 – July 2028. PI: Weldy, Chad
•Title of proposal: “ADAR Mediated RNA editing is a causal mechanism in coronary artery disease”.
•Activated 08/01/2023
•$850,000 over 5 years
Career Development Award, American Heart Association (AHA CDA)(23CDA1042900), July, 2023 – June, 2026. PI: Weldy, Chad
•Title of proposal: “Linking RNA editing to coronary artery calcification and disease”
•Activated 07/01/2023
•$231,000 over three years
NIH Loan Repayment Program (LRP) Award (NIH/NHLBI) Renewal Award, July, 2023. PI: Weldy, Chad
•Title of proposal: “RNA editing is a causal mechanism of coronary artery disease”
Ruth L. Kirschstein National Research Service Award (NRSA) Individual Postdoctoral Fellowship (F32) (NIH/NHLBI, 1 F32 HL160067-01), July, 2021 – June 2023 (Completed). PI: Weldy, Chad
• Titled, “A transcriptional network which governs smooth muscle transition is mediated by causal coronary artery disease gene PDGFD”
•*Received perfect score with impact score 10, 1st percentile
NIH Loan Repayment Program (LRP) Award (NIH/NHLBI), July, 2021. PI: Weldy, Chad
•Title of proposal: "Single cell transcriptomic and epigenomic features of human atherosclerosis".
•This will award up to $100,000 towards student loans over the next 24 months with opportunity for renewal after 24 months.
