Stanford University
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Barry Trost
Job and Gertrud Tamaki Professor in the School of Humanities and Sciences, Emeritus
BioBorn in Philadelphia, Pennsylvania, Barry Trost began his university training at the University of Pennsylvania (BA, 1962) and completed his Ph.D. in Chemistry at the Massachusetts Institute of Technology (1965). He moved directly to the University of Wisconsin, where he was promoted to Professor of Chemistry and subsequently Vilas Research Professor. He joined the faculty at Stanford as Professor of Chemistry in 1987 and became Tamaki Professor of Humanities and Sciences in 1990. In addition to serving multiple visiting professorships, Professor Trost was presented with a Docteur honoris causa of the Université Claude-Bernard (Lyon I), France, and in 1997 a Doctor Scientiarum Honoris Causa of the Technion, Haifa, Israel. In recognition of his innovations and scholarship in the field of organic synthesis, Professor Trost has received the ACS Award in Pure Chemistry, ACS Award for Creative Work in Synthetic Organic Chemistry, Arthur C. Cope Scholar Award, and the Presidential Green Chemistry Challenge Award, among many others. Professor Trost has been elected a Fellow of the American Academy of Arts and Sciences, American Chemical Society, and American Association for the Advancement of Science, and a member of the National Academy of Sciences, and served as Chairman of the NIH Medicinal Chemistry Study Section. He has held over 125 special university lectureships and presented over 270 Plenary Lectures at national and international meetings. He has published two books and over 950 scientific articles. He edited a major compendium entitled Comprehensive Organic Synthesis consisting of nine volumes and serves on the editorial board for Science of Synthesis and Reaxys.
The Trost Group’s research program revolves around the theme of synthesis, including target molecules with potential applications as novel catalysts, as well as antibiotic and antitumor therapies. The work comprises two major activities: 1) developing the tools, i.e., the reactions and reagents, and 2) creating the proper network of reactions to make complex targets readily available from simple starting materials.
Efforts to develop "chemists' enzymes" – non-peptidic transition metal based catalysts that can perform chemo-, regio-, diastereo-, and especially enantioselective reactions – focus close attention to the question of atom economy to minimize waste, energy, and consumption of raw materials.
Synthetic efficiency raises the question of metal catalyzed cycloadditions to rings other than six-membered. A general strategy is evolving for a "Diels-Alder" equivalent for formation of five, seven, nine, etc. membered carbo- and heterocyclic rings.
An exciting new direction derives from the molecular gymnastics acetylenes undergo in the presence of transition metals. Additional specific goals include cycloisomerization to virtually all types of ring sizes and systems with particularly versatile juxtaposition of functionality.
Palladium and ruthenium catalysts represent a major part of the lab's efforts, in order to invent new synthetic processes together with new opportunities for selectivity complementary to that obtained using other metal complexes. Main group chemistry, especially involving silicon, zinc, and sulfur, also offers many opportunities for new reaction design. Rational design of novel catalysts for asymmetric additions to carbonyl and imine groups are an exciting thrust.From these new synthetic tools evolve new synthetic strategies towards complex natural products. Targets include β-lactam antibiotics, ionophores, steroids and related compounds (e.g., Vitamin D metabolites), alkaloids, nucleosides, carbohydrates, and macrolide, terpenoid, and tetracyclic antitumor and antibiotic agents. -
Artem A. Trotsyuk, Ph.D.
Postdoctoral Scholar, Genetics
BioDr. Artem A. Trotsyuk is an AI Fellow in the Department of Genetics at Stanford University and an AI Special Projects Fellow at the Hoover Institution. He earned his PhD in Bioengineering and a Master’s in Computer Science with an AI specialization at Stanford, under the supervision of Dr. Geoffrey Gurtner in the Department of Surgery. He was co-advised by Dr. Zhenan Bao (Chemical Engineering), Dr. Russ Altman (Bioengineering and Medicine), and Dr. Michael Snyder (Genetics). His doctoral research focused on developing a smart bandage that integrates a closed-loop AI processing system for wound sensing and therapeutic delivery. His current work centers on evaluating AI tools in biomedicine, as well as special projects related to security, intent capture, and persona modeling.
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Milana Trounce
Clinical Professor, Emergency Medicine
BioDr. Boukhman Trounce graduated from the University of California San Francisco (UCSF) School of Medicine and went on to complete her emergency medicine residency and fellowship in Disaster Medicine and Bioterrorism Response at Harvard Medical School. She worked with the Center for Integration of Medicine and Technology (CIMT), a consortium of Harvard teaching hospitals and MIT, where she led BioSecurity related projects in conjunction with the US State Department. She also received her MBA from Stanford Business School.
After Harvard she joined UCSF as an Assistant Professor of Emergency Medicine and was Medical Director for Disaster Response. For the past 11 years, she has been at Stanford Medical School, where she is a Clinical Professor of Emergency Medicine.
She directs the BioSecurity program at Stanford, focused on protecting society from pandemics and other threats posed by infectious organisms, with a specific emphasis on approaches to interrupting transmission of infectious organisms in various settings. The background for the approach is outlined in her briefings at the Hoover Institute (see in publications list below). Stanford BioSecurity facilitates the creation of interdisciplinary solutions by bringing together experts in biology, medicine, public health, disaster management, policy, engineering, technology, and business. https://med.stanford.edu/biosecurity/about.html
At Stanford, over the past ten years she has established and directed a class on BioSecurity and Pandemic Resilience , which examines ways of building global societal resilience to pandemics and other biothreats and has educated over a thousand students. She has also taught an online Harvard course on medical response to biological terrorism, educating thousands of physicians globally.
She has served as a spokeswoman for the American College of Emergency Physicians (ACEP) and is a founding Chair of BioSecurity at ACEP. In addition to her academic research and speaking at national conferences, she also consults nationally and internationally to healthcare systems, governments, and other organizations. -
Megan Troxell
Professor of Pathology
Current Research and Scholarly InterestsBreast pathology, renal pathology, transplant pathology, immunohistochemistry
