Sarafan ChEM-H
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Chaitan Khosla
Wells H. Rauser and Harold M. Petiprin Professor and Professor of Chemistry and, by courtesy, of Biochemistry
Current Research and Scholarly InterestsResearch in this laboratory focuses on problems where deep insights into enzymology and metabolism can be harnessed to improve human health.
For the past two decades, we have studied and engineered enzymatic assembly lines called polyketide synthases that catalyze the biosynthesis of structurally complex and medicinally fascinating antibiotics in bacteria. An example of such an assembly line is found in the erythromycin biosynthetic pathway. Our current focus is on understanding the structure and mechanism of this polyketide synthase. At the same time, we are developing methods to decode the vast and growing number of orphan polyketide assembly lines in the sequence databases.
For more than a decade, we have also investigated the pathogenesis of celiac disease, an autoimmune disorder of the small intestine, with the goal of discovering therapies and related management tools for this widespread but overlooked disease. Ongoing efforts focus on understanding the pivotal role of transglutaminase 2 in triggering the inflammatory response to dietary gluten in the celiac intestine. -
Peter S. Kim
Virginia and D. K. Ludwig Professor of Biochemistry
Current Research and Scholarly InterestsOur research focuses on developing new strategies for vaccine creation. We also aim to generate vaccines targeting infectious agents that have eluded efforts to date. We integrate experimental approaches with protein language models to guide artificial evolution and enable efficient antibody and protein engineering. Our interdisciplinary approach aims to address critical global health challenges.
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Bruce Koch, Ph.D.
Director of High-Throughput Screening
Current Role at StanfordDirector, ChEM-H/CSB High Throughput Screening Group
Staff Lead, IMA HTS Module
Adviser to the SPARK Program -
Siddharth Krishnan
Assistant Professor of Electrical Engineering, and by courtesy, of Bioengineering and of Materials Science and Engineering
Current Research and Scholarly InterestsThe Krishnan Lab develops bioelectronic devices, tools and systems for closed loop disease management. Our work is divided into the following broad areas:
1. Biohybrid electronics for therapy and sensing: we combine living cells as functional parts of implantable devices, leveraging their ability to produce complex biologic therapeutics in a constitutive or triggerable manner, and their ability to sense their complex dynamic environment. These efforts are focused on developed functional cures for diseases like Type I Diabetes and other conditions requiring the regular infusion of proteins, peptides or antibody drugs.
2. Digital drug release systems for particulate forms of biologic drugs: Many complex protein and peptide drugs are not stable in solution, thereby frustrating the ability to delivery them through pumps and autoinjectors. This need is particularly acute for drugs that need to be administered as emergency rescue therapies, such as glucagon in the context of type 1 Diabetes. We develop implantable, miniaturized microelectromechanical devices that can store particulate (powders, pills) forms of these drugs and release them in a close loop manner based on wireless inputs from sensors.
3. Wearable sensors: Wearables to detect biophysical (temperature, flow, cardiac activity) and biochemical markers of health are gaining importance for closed-loop disease management and personalized medicine. We design hardware for on-chip molecular profiling based on sampling biofluids in noninvasive or minimally invasive formats.
4. New wireless power architectures for implantable bioelectronics: We develop high-power, high-efficiency strongly coupled power harvesting system to power battery-free implant systems.