Wu Tsai Neurosciences Institute
Showing 421-440 of 658 Results
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Derick Okwan
Assistant Professor of Pathology
Current Research and Scholarly InterestsBroadly, the Okwan lab’s primary interest is to understand how and why the immune system contributes to nearly all chronic diseases. The immune system of the modern human has evolved from a history of stress to the species: famines, continual bouts of lethal pandemics, as well as major climate/environmental and migratory changes that exposed the immune system to novel threats. At the forefront of these challenges are innate immune cells, particularly neutrophils, the most abundant leukocytes. For the first time in human history – at least in the western world- we live in an era of abundance. The Okwan lab is interested in understanding how this traumatic history creates a functional mismatch for the neutrophil, which we believe underpins their roles in chronic diseases of the modern era: cancer, cardiovascular disease, neurodegeneration, and autoimmune disorders. Rather than wholesale depletion of neutrophils and innate immune cells, we seek to identify novel approaches to leverage these cells to combat various diseases.
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Kunle Olukotun
Cadence Design Systems Professor, Professor of Electrical Engineering and of Computer Science
BioKunle Olukotun is the Cadence Design Professor of Electrical Engineering and Computer Science at Stanford University. Olukotun is a pioneer in multicore processor design and the leader of the Stanford Hydra chip multiprocessor (CMP) research project. He founded Afara Websystems to develop high-throughput, low-power multicore processors for server systems. The Afara multi-core processor, called Niagara, was acquired by Sun Microsystems and now powers Oracle's SPARC-based servers. In 2017, Olukotun co-founded SambaNova Systems, a Machine Learning and Artificial Intelligence company, and continues to lead as their Chief Technologist.
Olukotun is the Director of the Pervasive Parallel Lab and a member of the Data Analytics tor What's Next (DAWN) Lab, developing infrastructure for usable machine learning. He is a member of the National Academy of Engineering, an ACM Fellow, and an IEEE Fellow for contributions to multiprocessors on a chip design and the commercialization of this technology. He also received the Harry H. Goode Memorial Award.
Olukotun received his Ph.D. in Computer Engineering from The University of Michigan. -
Antonio Omuro, MD
Joseph D. Grant Professor
BioDr. Antonio M. Omuro, MD, FAAN, is the Chair of the Department of Neurology and Neurological Sciences at Stanford University School of Medicine.
Dr. Omuro is an internationally renowned neurologist and neuro-oncologist. Before assuming his role at Stanford, he held notable leadership positions at prestigious institutions including Yale University and Memorial Sloan Kettering Cancer Center. His research endeavors are concentrated on clinical and translational studies, where he collaborates closely with basic scientists to pioneer innovative therapies for challenging neuro-oncologic diseases such as gliomas and primary CNS lymphomas. He is also a highly esteemed educator and practicing clinician, delivering state-of-the-art and compassionate care to patients with brain tumors and neurological complications of cancers. -
Anthony Oro, MD, PhD
Eugene and Gloria Bauer Professor
Current Research and Scholarly InterestsOur lab uses the skin to answer questions about epithelial stem cell biology, differentiation and carcinogenesis using genomics, genetics, and cell biological techniques. We have studied how hedgehog signaling regulates regeneration and skin cancer, and how tumors evolve to develop resistance. We study the mechanisms of early human skin development using human embryonic stem cells. These fundamentals studies provide a greater understanding of epithelial biology and novel disease therapeutics.
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Michael Ostacher
Professor of Psychiatry and Behavioral Sciences (Public Mental Health and Population Sciences)
BioDr. Ostacher is Professor of Psychiatry and Behavioral Sciences. He is the Site Director for the Addiction Medicine Fellowship at the VA Palo Alto Health Care System, where he also serves as the Medical Director of the Pharmacology of Addiction Recovery Clinic, the Director of the Bipolar and Depression Research Program and the Co-Director of the VA/Stanford Exploratory Therapeutics Lab, the Director of Advanced Fellowship Training in Mental Illness Research and Treatment for MDs for the VISN 21 MIRECC, and the Site Director at the VA Palo Alto for Advanced Fellowship Training for Stanford. A graduate of Vanderbilt University School of Medicine, the Harvard School of Public Health, and Harvard Medical School, he completed his training at The Cambridge Health Alliance at Harvard Medical School in Adult Psychiatry, Public Psychiatry, and Geriatric Psychiatry, and is currently board certified in Psychiatry, Addiction Psychiatry, and Addiction Medicine. He is the Digital Content Editor for the journal Evidence-Based Mental Health and is on the editorial boards of Bipolar Disorders, the International Journal of Bipolar Disorders, the Journal of Clinical Psychiatry, Current Psychiatry, and Psychiatric Annals. His current research includes roles as Site Investigator for VA-BRAVE, multicenter, randomized trial comparing long-acting injectable buprenorphine to sublingual buprenorphine/naloxone, and trials of psychedelic drugs in psychiatric disorders in Veterans. With funding from NIDA, he studied, along with Jaimee Heffner, Ph.D. at the Fred Hutchinson Cancer Research Center in Seattle, smoking cessation in people with bipolar disorder using a novel online psychotherapy derived from Acceptance and Commitment Therapy. His work using a Capnometry Guided Respiratory Intervention (CGRI) for PTSD led to the FDA clearance for Freespira, a digital therapeutic, for the treatment of PTSD. His primary research interest is in large clinical trials mental health and addiction, and the implementation of evidence-based mental health practices.
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Einar Ottestad
Clinical Professor, Anesthesiology, Perioperative and Pain Medicine
Current Research and Scholarly InterestsI have a strong interest in ultrasound for chronic pain management for diagnostics as well as therapeutics. I also have strong interest in acute pain in the hospital setting, including post-operative as well as cancer pain.
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Nicholas Ouellette
Professor of Civil and Environmental Engineering
Current Research and Scholarly InterestsThe Environmental Complexity Lab studies self-organization in a variety of complex systems, ranging from turbulent fluid flows to granular materials to collective motion in animal groups. In all cases, we aim to characterize the macroscopic behavior, understand its origin in the microscopic dynamics, and ultimately harness it for engineering applications. Most of our projects are experimental, though we also use numerical simulation and mathematical modeling when appropriate. We specialize in high-speed, detailed imaging and statistical analysis.
Our current research includes studies of turbulence in two and three dimensions, with a focus on coherent structures and the geometry of turbulence; the transport of inertial, anisotropic, and active particles in turbulence; the erosion of granular beds by fluid flows and subsequent sediment transport; quantitative measurements of collective behavior in insect swarms and bird flocks; the stability of ocean ecosystems; neural signal processing; and uncovering the natural, self-organized spatiotemporal scales in urban systems. -
Art Owen
Max H. Stein Professor
Current Research and Scholarly InterestsStatistical methods to analyze large data matrices in bioinformatics
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Cholawat Pacharinsak, DVM, PhD
Professor of Comparative Medicine
BioCholawat Pacharinsak, DVM, PhD Professor and Director of Anesthesia, Pain Management, and Surgery, at Stanford University’s Department of Comparative Medicine; he is a Diplomate of the American College of Veterinary Anesthesia and Analgesia (DACVAA). He received his DVM from Chulalongkorn University, Thailand and trained in an Anesthesiology/Pain Management residency program and received his Master's degree at Washington State University. He completed his PhD in Comparative and Molecular Biosciences from the University of Minnesota. Prior to arriving at Stanford, Dr. Pacharinsak was a faculty member in Anesthesiology and Pain Management at Michigan State University and Purdue University; and served as a Clinical Specialist at UCLA’s David Geffen School of Medicine. His research focuses on understanding the neurobiology of cancer pain, chemotherapeutic-induced peripheral neuropathy, acute surgical pain models, and methods to improve clinical pain management e.g. sustained release analgesics supporting refinement. Research methodology includes electrophysiologic and behavioral techniques.
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Daniel Palanker, PhD
Professor of Ophthalmology and, by courtesy, of Electrical Engineering
Current Research and Scholarly InterestsInteractions of electric field and light with biological cells and tissues and their applications to imaging, diagnostics, therapeutics and prosthetics, primarily in ophthalmology.
Specific fields of interest:
Electronic retinal prosthesis;
Electronic enhancement of tear secretion;
Electronic control of blood vessels;
Interferometric imaging of neural signals;
Interferometric imaging of cellular physiology -
Theo Palmer
Professor of Neurosurgery, Emeritus
Current Research and Scholarly InterestsMembers of the Palmer Lab study the biology of neural stem cells in brain development and in the adult. Our primary goal is to understand how genes and environment synergize in influencing stem cell behavior during development and how mild genetic or environmental risk factors for disease may synergize in their detrimental effects on brain development or in the risk of neuronal loss in age-related degenerative disease.
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David J. Park, MD, PhD, FCNS
Clinical Assistant Professor, Neurosurgery
Current Research and Scholarly InterestsThe goal of our Laboratory is to improve patients’ care and outcomes by analyzing clinical data from thousands of patients treated at our institution. Our current primary areas of interest are benign tumors, brain and spine metastases, and neurogenetic disorders.
Our lab is led by Dr. Steven D. Chang and Dr. David J. Park and proudly hosts talented young clinical scientists from around the world.
Link: https://med.stanford.edu/neurosurgery/research/NeuroOncLab.html -
Karen J. Parker, PhD
Truong-Tan Broadcom Endowed Professor and Professor, by courtesy, of Comparative Medicine
Current Research and Scholarly InterestsThe Parker Lab conducts research on the biology of social functioning in monkeys, typically developing humans, and patients with social difficulties.
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Sonia Partap
Clinical Professor, Pediatric Neurology
Clinical Professor (By courtesy), Neurosurgery
Clinical Professor (By courtesy), PediatricsCurrent Research and Scholarly InterestsMy research interests involve the epidemiology, treatment and diagnosis of pediatric and young adult brain tumors. I am also interested in long-term neurologic effects and designing clinical trials to treat brain and spinal cord tumors.
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Josef Parvizi, MD, PhD
Professor of Neurology and Neurological Sciences (Adult Neurology) and, by courtesy, of Neurosurgery
BioDr. Parvizi completed his medical internship at Mayo Clinic, neurology training at Harvard, and subspecialty training in clinical neurophysiology and epilepsy at UCLA before joining the Department of Neurology and Neurological Sciences at Stanford in 2007. Dr. Parvizi directs the Stanford Program for Medication Resistant Epilepsies and specializes in surgical treatments of intractable focal epilepsies. Dr. Parvizi is the principal investigator in the Laboratory of Behavioral and Cognitive Neuroscience, where he leads a team of investigators to study the human brain. http://med.stanford.edu/parvizi-lab.html.
Epilepsy patient story: https://www.youtube.com/watch?v=HXy-gXg0t94&t=3s -
Sergiu P. Pasca
Kenneth T. Norris, Jr. Professor of Psychiatry and Behavioral Sciences and Bonnie Uytengsu and Family Director of the Stanford Brain Organogenesis Program and Senior Fellow, by courtesy, at the Hoover Institution
Current Research and Scholarly InterestsA critical challenge in understanding the intricate programs underlying development, assembly and dysfunction of the human brain is the lack of direct access to intact, functioning human brain tissue for detailed investigation by imaging, recording, and stimulation.
To address this, we are developing bottom-up approaches to generate and assemble, from multi-cellular components, human neural circuits in vitro and in vivo.
We introduced the use of instructive signals for deriving from human pluripotent stem cells self-organizing 3D cellular structures named brain region-specific spheroids/organoids. We demonstrated that these cultures, such as the ones resembling the cerebral cortex, can be reliably derived across many lines and experiments, contain synaptically connected neurons and non-reactive astrocytes, and can be used to gain mechanistic insights into genetic and environmental brain disorders. Moreover, when maintained as long-term cultures, they recapitulate an intrinsic program of maturation that progresses towards postnatal stages.
We also pioneered a modular system to integrate 3D brain region-specific organoids and study human neuronal migration and neural circuit formation in functional preparations that we named assembloids. We have actively applied these models in combination with studies in long-term ex vivo brain preparations to acquire a deeper understanding of human physiology, evolution and disease mechanisms.
We have carved a unique research program that combines rigorous in vivo and in vitro neuroscience, stem cell and molecular biology approaches to construct and deconstruct previously inaccessible stages of human brain development and function in health and disease.
We believe science is a community effort, and accordingly, we have been advancing the field by broadly and openly sharing our technologies with numerous laboratories around the world and organizing the primary research conference and the training courses in the area of cellular models of the human brain. -
Chirag Patel, MD, PhD
Member, Cardiovascular Institute
Current Research and Scholarly InterestsNeuro-oncology, Clinical Trials, Tumor Treating Fields (TTFields), Molecular/PET Imaging, Neuroimaging, Immunotherapy, Big Data Analysis
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Zara M. Patel, MD
Professor of Otolaryngology - Head & Neck Surgery (OHNS) and, by courtesy, of Neurosurgery
Current Research and Scholarly InterestsCurrently performing research studies in Smell and Taste Disorders,Artificial Intelligence in Rhinology, Chronic Sinusitis and Endoscopic Sinus Surgery, Endoscopic Skull Base Surgery.
