Honors & Awards

  • Tau Beta Pi Membership, Tau Beta Pi Honor Society (2017)
  • ADVANCE Fellow, Stanford University (2018)
  • Boeing Scholarship, The Boeing Company (2017)
  • Harold P. Brown Engineering Fellowship, Washington University in St. Louis McKelvey School of Engineering (2016)
  • Goldwater Scholarship Honorable Mention, Barry Goldwater Scholarship Foundation (2016)

Education & Certifications

  • Master of Science, Stanford University, BIOPH-MS (2021)
  • M.S., Stanford University, Biophysics (2021)
  • B.S., Washington University in St. Louis, Systems Engineering (2018)
  • B.S., Washington University in St. Louis, Computer Science (2018)
  • B.S., Whitworth University, Biophysics (2018)

Stanford Advisors

Current Research and Scholarly Interests

I am an MD/PhD candidate in Biophysics at Stanford University, and work with Olivier Gevaert in the Department of Biomedical Data Science and the Center for Artificial Intelligence in Medicine and Imaging.

My research interests are broadly in the development of theoretical and applied solutions to problems at the intersection of machine learning and medicine. In particular, my current work is in representation learning and computer vision (both primarily for brain MRI scans), and I've recently started working on privacy-preserving machine learning.

Previously I've worked in such areas as theoretical biophysics (with Shamit Kachru at Stanford), algorithms for computational neuroscience (with Ralf Wessel and Benjamin Moseley at WUStL), inverse optimization (with Alejandro Rodriguez at Princeton), and computational drug design (with Matt Jacobson at UCSF).

I graduated from the dual degree program at Washington University in St. Louis in 2018, with three B.S. degrees respectively in physics (with a biophysics concentration), computer science, and systems engineering.

Current Clinical Interests

  • Neurosurgery
  • Pediatric Neurosurgery
  • Medical Oncology

All Publications

  • Pre-Synaptic Pool Modification (PSPM): A supervised learning procedure for recurrent spiking neural networks. PloS one Bagley, B. A., Bordelon, B., Moseley, B., Wessel, R. 2020; 15 (2): e0229083


    Learning synaptic weights of spiking neural network (SNN) models that can reproduce target spike trains from provided neural firing data is a central problem in computational neuroscience and spike-based computing. The discovery of the optimal weight values can be posed as a supervised learning task wherein the weights of the model network are chosen to maximize the similarity between the target spike trains and the model outputs. It is still largely unknown whether optimizing spike train similarity of highly recurrent SNNs produces weight matrices similar to those of the ground truth model. To this end, we propose flexible heuristic supervised learning rules, termed Pre-Synaptic Pool Modification (PSPM), that rely on stochastic weight updates in order to produce spikes within a short window of the desired times and eliminate spikes outside of this window. PSPM improves spike train similarity for all-to-all SNNs and makes no assumption about the post-synaptic potential of the neurons or the structure of the network since no gradients are required. We test whether optimizing for spike train similarity entails the discovery of accurate weights and explore the relative contributions of local and homeostatic weight updates. Although PSPM improves similarity between spike trains, the learned weights often differ from the weights of the ground truth model, implying that connectome inference from spike data may require additional constraints on connectivity statistics. We also find that spike train similarity is sensitive to local updates, but other measures of network activity such as avalanche distributions, can be learned through synaptic homeostasis.

    View details for DOI 10.1371/journal.pone.0229083

    View details for PubMedID 32092107