All Publications

  • Pulling instead of pushing: A case report of gastrostomy-assisted pull technique as an alternative method for endoluminal sponge placement in EVAC therapy Trocchia, C., Shieh, H., Dolan, I., Wilsey, M., Smithers, C. Johns Hopkins All Children’s Hospital. 2024
  • Percutaneous-Endoscopic Rendezvous Procedure in a Pediatric Patient With Biliary Obstruction and Altered Anatomy. Journal of pediatric gastroenterology and nutrition Mauer, T. L., Trocchia, C., Collard, M., Chandler, N. M., Poulos, N., Wilsey, M. 2023; 77 (4): e67

    View details for DOI 10.1097/MPG.0000000000003842

    View details for PubMedID 37229766

  • Navigating Uncertainty in Medicine With Our Families. Pediatrics Trocchia, C., Singh, P., Inglese, C., Goding, D., Matta, E., Dudas, R. 2023; 151 (4)

    View details for DOI 10.1542/peds.2022-059783

    View details for PubMedID 36866465

  • Pediatric ERCP in the Setting of Acute Pancreatitis: A Secondary Analysis of an International Multicenter Cohort Study. Journal of pediatric gastroenterology and nutrition Trocchia, C., Khalaf, R., Amankwah, E., Ruan, W., Fishman, D. S., Barth, B. A., Liu, Q. Y., Giefer, M., Kim, K. M., Martinez, M., Dall'oglio, L., Torroni, F., De Angelis, P., Faraci, S., Bitton, S., Werlin, S., Dua, K., Gugig, R., Huang, C., Mamula, P., Quiros, J. A., Zheng, Y., Piester, T., Grover, A., Fox, V. L., Wilsey, M., Troendle, D. M. 2023

    Abstract

    Previous studies have demonstrated the safety of performing Endoscopic Retrograde Cholangiopancreatography (ERCP) in the pediatric population; however, few have addressed the outcomes of children undergoing ERCP during acute pancreatitis (AP). We hypothesize that ERCP performed in the setting of AP can be executed with similar technical success and adverse event profiles to those in pediatric patients without pancreatitis. Using the Pediatric ERCP Database Initiative, a multi-national and multi-institutional prospectively collected dataset, we analyzed 1124 ERCPs. One hundred and ninety-four (17%) of these procedures were performed in the setting of AP. There were no difference in the procedure success rate, procedure time, cannulation time, fluoroscopy time or American Society of Anesthesiology class despite patients with AP having higher ASGE difficulty grading scores. This study suggests that ERCP can be safely and efficiently performed in pediatric patients with AP when appropriately indicated.

    View details for DOI 10.1097/MPG.0000000000003762

    View details for PubMedID 36913706

  • Lymphatic Leakage in Pediatric Heart Transplantation: Early Recognition and Timely Management with Interventional Radiologic and Endoscopic Therapy Trocchia, C., Mauer, t., Mitchell, S., Collard, M., Asante-Korang, A., Wilsey, M. JPGN Reports. 2023
  • A Milk-Fat Based Diet Increases Metastasis in the MMTV-PyMT Mouse Model of Breast Cancer. Nutrients Velazquez, F. N., Viscardi, V., Montemage, J., Zhang, L., Trocchia, C., Delamont, M. M., Ahmad, R., Hannun, Y. A., Obeid, L. M., Snider, A. J. 2021; 13 (7)

    Abstract

    A high-fat diet (HFD) and obesity are risk factors for many diseases including breast cancer. This is particularly important with close to 40% of the current adult population being overweight or obese. Previous studies have implicated that Mediterranean diets (MDs) partially protect against breast cancer. However, to date, the links between diet and breast cancer progression are not well defined. Therefore, to begin to define and assess this, we used an isocaloric control diet (CD) and two HFDs enriched with either olive oil (OOBD, high in oleate, and unsaturated fatty acid in MDs) or a milk fat-based diet (MFBD, high in palmitate and myristate, saturated fatty acids in Western diets) in a mammary polyomavirus middle T antigen mouse model (MMTV-PyMT) of breast cancer. Our data demonstrate that neither MFBD or OOBD altered the growth of primary tumors in the MMTV-PyMT mice. The examination of lung metastases revealed that OOBD mice exhibited fewer surface nodules and smaller metastases when compared to MFBD and CD mice. These data suggest that different fatty acids found in different sources of HFDs may alter breast cancer metastasis.

    View details for DOI 10.3390/nu13072431

    View details for PubMedID 34371939

    View details for PubMedCentralID PMC8308868

  • Loss of sphingosine kinase 1 increases lung metastases in the MMTV-PyMT mouse model of breast cancer. PloS one Velazquez, F. N., Zhang, L., Viscardi, V., Trocchia, C., Hannun, Y. A., Obeid, L. M., Snider, A. J. 2021; 16 (5): e0252311

    Abstract

    Breast cancer is a very heterogeneous disease, and ~30% of breast cancer patients succumb to metastasis, highlighting the need to understand the mechanisms of breast cancer progression in order to identify new molecular targets for treatment. Sphingosine kinase 1 (SK1) has been shown to be upregulated in patients with breast cancer, and several studies have suggested its involvement in breast cancer progression and/or metastasis, mostly based on cell studies. In this work we evaluated the role of SK1 in breast cancer development and metastasis using a transgenic breast cancer model, mouse mammary tumor virus-polyoma middle tumor-antigen (MMTV-PyMT), that closely resembles the characteristics and evolution of human breast cancer. The results show that SK1 deficiency does not alter tumor latency or growth, but significantly increases the number of metastatic lung nodules and the average metastasis size in the lung of MMTV-PyMT mice. Additionally, analysis of Kaplan-Meier plotter of human disease shows that high SK1 mRNA expression can be associated with a better prognosis for breast cancer patients. These results suggest a metastasis-suppressing function for SK1 in the MMTV-PyMT model of breast cancer, and that its role in regulating human breast cancer progression and metastasis may be dependent on the breast cancer type.

    View details for DOI 10.1371/journal.pone.0252311

    View details for PubMedID 34043703

    View details for PubMedCentralID PMC8158862