Clinical Focus


  • Pediatric Hematology-Oncology

Academic Appointments


Honors & Awards


  • AOA, Medical Honor Society (2007)
  • Fellow, Rachleff Hem-Onc Pediatric Fellowship fund (2012-2013)

Professional Education


  • Board Certification: Pediatrics, American Board of Pediatrics (2010)
  • Board Certification: Pediatric Hematology-Oncology, American Board of Pediatrics (2015)
  • Medical Education:Tufts University School of Medicine (2007) MA
  • Residency:Massachusetts General HospitalMA
  • Internship:Massachusetts General HospitalMA
  • Fellowship:Lucile Packard Children's HospitalCA
  • Chief Resident, Massachusetts General Hospital for Children, Pediatrics (2011)
  • Resident, Massachusetts General Hospital for Children, Pediatrics (2010)
  • Doctor of Medicine, Tufts University School of Medicine (2007)

Current Research and Scholarly Interests


I am interested in the prevention and management of infectious complication in pediatric oncology patients. I am currently conducting a retrospective chart review of voriconazole vs. fluconazole for the prevention of invasive fungal disease after allogeneic stem cell transplant. I am also interested in developing a protocol for the management of low risk patients with fever and neutropenia.

All Publications


  • Evaluation of Febrile, Nonneutropenic Pediatric Oncology Patients with Central Venous Catheters Who Are Not Given Empiric Antibiotics JOURNAL OF PEDIATRICS Bartholomew, F., Aftandilian, C., Andrews, J., Gutierrez, K., Luna-Fineman, S., Jeng, M. 2015; 166 (1): 157-162

    Abstract

    To evaluate the practice of empiric antibiotics for febrile, nonneutropenic pediatric oncology patients with a central venous catheter (CVC) in place.Episodes of fever without neutropenia (absolute neutrophil count [ANC] ≥500 cells/mm(3)) were reviewed retrospectively in pediatric oncology patients with a CVC undergoing chemotherapy. Characteristics and symptoms were compared between patients with bacteremia and patients without bacteremia.A total of 392 episodes of nonneutropenic fever in 138 subjects (52 females; 38%) were reviewed. In this cohort, the median age at an episode was 7 years, and the majority of patients had a diagnosis of acute leukemia (54%). Median ANC was 3100 cells/mm(3) (IQR, 1570-5980 cells/mm(3)). Median temperature was 38.7°C (IQR, 38.3-39.2°C). Twenty-four infectious episodes (6%) occurred in 18 subjects, and 5 CVCs required removal; all patients requiring removal admitted and received antibiotics owing to chills. There were no significant difference in age, sex, or ANC between patients with bacteremia and those without bacteremia; however, mean temperature was higher in the patients with bacteremia (39.4°C vs 38.7°C; P = .003). No deaths due to sepsis occurred, and no CVCs were removed because antibiotics were not administered empirically.Our practice of observing pediatric oncology patients undergoing chemotherapy with CVCs who are not neutropenic does not appear to lead to increased serious adverse outcomes and avoids antibiotic exposure for >90% of patients without a bacterial infection.

    View details for DOI 10.1016/j.jpeds.2014.09.008

    View details for Web of Science ID 000346584000032

    View details for PubMedID 25444524

  • The Neutropenic Diet ... Still Ageless? C. Aftandilian Article Reviewed ONCOLOGY-NEW YORK Aftandilian, C. C., Milotich, C., Sakamoto, K. M. 2012; 26 (6): 586-589
  • The neutropenic diet... still ageless? Oncology (Williston Park, N.Y.) Aftandilian, C. C., Milotich, C., Sakamoto, K. M. 2012; 26 (6): 586-?

    View details for PubMedID 22870544

  • Burkitt Lymphoma With Pancreatic Involvement JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY Aftandilian, C. C., Friedmann, A. M. 2010; 32 (8): E338-E340

    Abstract

    A 10-year-old boy was referred to our clinic for tonsillectomy and was found to have a large mass within his oropharynx. Intraoperative biopsies confirmed Burkitt lymphoma. Further imaging and biopsy revealed pancreatic involvement. He was treated with multiagent chemotherapy. He remains disease-free 6 years later. Review of the literature demonstrates other cases of non-Hodgkin lymphoma with pancreatic involvement with good outcomes. Pancreatic involvement is a relatively rare occurrence in childhood lymphoma.

    View details for DOI 10.1097/MPH.0b013e3181ed1178

    View details for Web of Science ID 000283538300021

    View details for PubMedID 20930650

  • Group therapy for substance use disorders: What do we know? HARVARD REVIEW OF PSYCHIATRY Weiss, R. D., Jaffee, W. B., de Menil, V. P., Cogley, C. B. 2004; 12 (6): 339-350

    Abstract

    Although group therapy is the most prevalent treatment modality for substance use disorders, an up-to-date review of treatment outcome literature does not exist. A search of the literature yielded 24 treatment outcome studies comparing group therapy to other treatment conditions. These studies fell into one of six research design categories: (1) group therapy versus no group therapy; (2) group therapy versus individual therapy; (3) group therapy plus individual therapy versus group therapy alone; (4) group therapy plus individual therapy versus individual therapy alone; (5) group therapy versus another group therapy with different content or theoretical orientation; and (6) more group therapy versus less group therapy. In general, treatment outcome studies did not demonstrate differences between group and individual modalities, and no single type of group therapy reliably demonstrated greater efficacy than others. Unique methodological and logistical hurdles encountered in research on group therapy for substance use disorders, as well as considerations for future research, are also discussed.

    View details for DOI 10.1080/1067322049095723

    View details for Web of Science ID 000226593100004

    View details for PubMedID 15764469

  • Requiring remission of undue influence of weight and shape on self-evaluation in the definition of recovery for bulimia nervosa INTERNATIONAL JOURNAL OF EATING DISORDERS Cogley, C. B., Keel, P. K. 2003; 34 (2): 200-210

    Abstract

    The current study evaluated the concurrent validity of requiring remission of undue influence of weight and shape on self-evaluation (undue influence) in defining recovery from bulimia nervosa (BN).Three groups completed the Beck Depression Inventory, the Mood and Anxiety Symptom Questionnaire, the Body Shape Questionnaire, and the Social Adjustment Scale: 31 women were fully recovered from BN (FR), 28 women had no behavioral symptoms of BN (partially recovered [PR]), and 59 matched non-eating-disordered controls (MC).The PR group had more pathologic scores on depression, anxiety, body dissatisfaction, and social adjustment compared with both the FR and MC groups, which did not differ from each other.These findings suggest that including remission of cognitive symptoms in a standardized definition of recovery may prove to be clinically useful in establishing reliable prognostic indicators. Future research should evaluate the role played by cognitive symptoms in triggering relapse.

    View details for DOI 10.1002/eat.10187

    View details for Web of Science ID 000184510900003

    View details for PubMedID 12898556