Christine Ng

All Publications

• Recent advances in induced proximity modalities. Current opinion in chemical biology Ng, C. S., Banik, S. M. 1800; 67: 102107

  Abstract

  Challenging disease targets necessitate new approaches for therapeutic intervention. Rewiring protein-biomolecule interactions with proximity-inducing agents extends intervention opportunities beyond target agonism or inhibition. Spanning varied molecular phenotypes and diverse target classes, proximity-inducing agents demonstrate immense potential across target degradation, cleavage, and post-translational editing. Here, we review a selection of exciting developments in the concepts and mechanisms of induced proximity-driven strategies from the last two years. Key technological advances that enable these discoveries and expand the scope of targets and machinery for induced-proximity modalities are highlighted.

  View details for DOI 10.1016/j.cbpa.2021.102107

  View details for PubMedID 35033823

• Taming transcription factors with TRAFTACs. Cell chemical biology Ng, C. S., Banik, S. M. 2021; 28 (5): 588-590

  Abstract

  Transcription factors play central roles in numerous diseases yet are notoriously challenging targets for drug development. In this issue of Cell Chemical Biology, Samarasinghe etal. (2021) describe a modular approach to targeting transcription factors for degradation with TRAFTACs, without the need for extensive ligand development campaigns.

  View details for DOI 10.1016/j.chembiol.2021.04.016

  View details for PubMedID 34019844