Recent advances in induced proximity modalities.
Current opinion in chemical biology
1800; 67: 102107
Challenging disease targets necessitate new approaches for therapeutic intervention. Rewiring protein-biomolecule interactions with proximity-inducing agents extends intervention opportunities beyond target agonism or inhibition. Spanning varied molecular phenotypes and diverse target classes, proximity-inducing agents demonstrate immense potential across target degradation, cleavage, and post-translational editing. Here, we review a selection of exciting developments in the concepts and mechanisms of induced proximity-driven strategies from the last two years. Key technological advances that enable these discoveries and expand the scope of targets and machinery for induced-proximity modalities are highlighted.
View details for DOI 10.1016/j.cbpa.2021.102107
View details for PubMedID 35033823
Taming transcription factors with TRAFTACs.
Cell chemical biology
2021; 28 (5): 588-590
Transcription factors play central roles in numerous diseases yet are notoriously challenging targets for drug development. In this issue of Cell Chemical Biology, Samarasinghe etal. (2021) describe a modular approach to targeting transcription factors for degradation with TRAFTACs, without the need for extensive ligand development campaigns.
View details for DOI 10.1016/j.chembiol.2021.04.016
View details for PubMedID 34019844