Christopher Mow

All Publications

• Dual Mobility in Total Hip Arthroplasty: Biomechanics, Indications and Complications-Current Concepts INDIAN JOURNAL OF ORTHOPAEDICS Patil, N., Deshmane, P., Deshmukh, A., Mow, C. 2021

  View details for DOI 10.1007/s43465-021-00471-w

  View details for Web of Science ID 000707925800001

• Periprosthetic Joint Infection: Clinical and Bench SCIENTIFIC WORLD JOURNAL Lee, M. S., Freiberg, A., Klauser, W., Mow, C. S., Kim, S. 2013: 134786

  View details for PubMedID 24453790

• High revision rate after total elbow arthroplasty with a linked semiconstrained device. Orthopedics Patil, N., Cheung, E. V., Mow, C. S. 2009; 32 (5): 321-?

  Abstract

  The clinical results of semiconstrained total elbow arthroplasty have been encouraging, especially in rheumatoid arthritis. This article presents medium-term clinical results, revision rates, and reasons for revision of a semiconstrained linked total elbow device (Solar Total Elbow; Stryker, Mahwah, New Jersey). We retrospectively reviewed 17 consecutive total elbow arthroplasty patients operated on between February 1994 and March 2001. Thirteen patients were available for clinical evaluation with an average follow-up of 8.4 years (range, 4-12.6 years). The presenting diagnosis was posttraumatic arthritis in 6 patients, rheumatoid arthritis in 6, and gouty arthritis in 1, with an average patient age of 63.4 years. The results were analyzed with regard to complications following the procedure, functional outcome using the Mayo Elbow Performance Score (MEPS), and radiological evaluation at latest follow-up. The mean MEPS improved from 32.1 to 65 at latest follow-up. Three patients had excellent results, 5 had good results, 1 had a fair result, and 4 had poor results. Seven patients required at least 1 revision surgery, including 2 with humeral component loosening, 2 with ulnar component loosening, and 2 with bushing failure. One patient required resection arthroplasty for deep periprosthetic infection. Three patients eventually sustained periprosthetic fractures. Five patients with rheumatoid arthritis and 2 patients with posttraumatic arthritis underwent revision surgery. Poor clinical outcomes and a high revision rate were noted in patients with posttraumatic arthritis. Further comparative studies with other semiconstrained devices are necessary to determine their clinical effectiveness in patients with rheumatoid arthritis.

  View details for PubMedID 19472967

• Age at onset-dependent presentations of premature hip osteoarthritis, avascular necrosis of the femoral head, or Legg-Calve-Perthes disease in a single family, consequent upon a p.Gly1170Ser mutation of COL2A1 ARTHRITIS AND RHEUMATISM Su, P., Li, R., Liu, S., Zhou, Y., Wang, X., Patil, N., Mow, C. S., Mason, J. C., Huang, D., Wang, Y. 2008; 58 (6): 1701-1706

  Abstract

  To identify the genetic abnormality responsible for osteoarthritis (OA), avascular necrosis (AVN) of the femoral head, and Legg-Calvé-Perthes disease in a single family, and to determine factors responsible for the distinct phenotypes manifested by different family members.Forty-two members of a 5-generation family were recruited and investigated. Diagnosis was made by independent orthopedic surgeons and radiologists. Histopathologic changes of the diseased tissue were examined. Linkage analysis was performed with markers spanning the COL2A1 locus. Haplotypes were constructed and mutation of the gene was detected. Structures of the wild-type and mutant proteins were modeled.Sixteen affected members were identified (5 with isolated precocious hip OA, 6 with AVN of the femoral head, and 5 with Legg-Calvé-Perthes disease). A p.Gly1170Ser mutation of COL2A1 cosegregated with the 3 diseases and was absent in controls. Of note, age at onset in relation to the closure status of the femoral head epiphysis was associated with the diseases, with Legg-Calvé-Perthes disease presenting prior to closure (at ages 6-14 years), AVN of the femoral head presenting during closure (at ages 15-18 years), and precocious OA of the hip presenting after closure (at ages 21-34 years). Molecular modeling predicted that the serine-to-glycine substitution loosens the helical structure of the protein.The p.Gly1170Ser mutation of COL2A1 in the family described is responsible for pathology confined to the hip joint, which presents as isolated precocious hip OA, AVN of the femoral head, or Legg-Calvé-Perthes disease. Age at onset in relation to closure of the femoral head epiphysis appears to be a critical factor in determining disease pattern.

  View details for DOI 10.1002/art.23491

  View details for Web of Science ID 000256724900017

  View details for PubMedID 18512791

• Polyethylene Wear Particle Induced Osteolysis in Total Hip Replacement MALAYSIAN ORTHOPAEDIC JOURNAL Patil, N., Jin, W., Mow, C. S. 2008; 2 (1): 1–7

  View details for Web of Science ID 000447491500001

• Comparison of scars from total hip replacements done with a standard or a mini-incision CLINICAL ORTHOPAEDICS AND RELATED RESEARCH Mow, C. S., Woolson, S. T., Ngarmukos, S. G., Park, E. H., Lorenz, H. P. 2005: 80-85

  Abstract

  Scar cosmesis is one of the proposed benefits of mini-incision total hip replacement as opposed to standard-incision procedures; however, there has been no scientific proof of this clinical outcome. The cosmetic appearances of healed incisions of 34 primary total hip replacement procedures done by one surgeon using either a mini-incision (20 procedures) or a standard-length incision (14 procedures) were compared at an average of 2 years postoperatively. Each scar's appearance was graded independently by two plastic surgeons using a standardized rating system. Patients answered a questionnaire regarding their subjective assessment of their scar. The blinded observers found that more mini-scars (six of 20) were rated poor than standard scars (one of 14) and that more standard-incision patients had scars that were rated good. More mini-incision patients (two of 20 versus zero of 14) had wound-healing problems. All the patients thought that their hip scar was acceptable in appearance, but 30 of 31 patients rated the relief of pain and total hip replacement longevity as higher priorities than scar cosmesis. The cosmesis of mini-incision total hip replacement scars may be inferior to standard-incision scars because of skin and soft tissue damage produced by high retractor pressures needed for exposure using a limited skin incision. Level of Evidence: Therapeutic study, Level II-2 (prospective comparative study). See the Guidelines for Authors for a complete description of levels of evidence.

  View details for DOI 10.1097/01.blo.0000191317.85422.c3

  View details for Web of Science ID 000233794700015

  View details for PubMedID 16330988

• Comparison of primary total hip replacements performed with a standard incision or a mini-incision JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME Woolson, S. T., Mow, C. S., Syquia, J. F., Lannin, J. V., Schurman, D. J. 2004; 86A (7): 1353-1358

  Abstract

  Primary total hip replacement performed through an incision that is

  View details for Web of Science ID 000222475900001

• Comparison of primary total hip replacements performed with a standard incision or a mini-incision. journal of bone and joint surgery. American volume Woolson, S. T., Mow, C. S., Syquia, J. F., Lannin, J. V., Schurman, D. J. 2004; 86-A (7): 1353-1358

  Abstract

  Primary total hip replacement performed through an incision that is

  View details for PubMedID 15252080