Claire Baum
Postdoctoral Scholar, Neurosurgery
All Publications
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Functional characterization of pig retinal ganglion cells
ASSOC RESEARCH VISION OPHTHALMOLOGY INC. 2026
View details for Web of Science ID 001878017700044
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Modulating Aberrant Retinal Activity in Degeneration to Enhance Artificial Vision
ASSOC RESEARCH VISION OPHTHALMOLOGY INC. 2026
View details for Web of Science ID 001880635300036
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Leveraging current steering and the biophysics of spike generation for cellular-resolution electrical stimulation of neurons.
Cell reports
2026; 45 (2): 116917
Abstract
Electrical stimulation at cellular resolution to restore the function of neural circuits is limited by the density of available electrode arrays. Although current steering with multi-electrode stimulation can be used to target cells between electrodes, it has not been proven for systematically targeting individual cells. We develop a framework for cellular-resolution current steering, leveraging the biophysics of electrically evoked spike generation, and test its efficacy in isolated macaque and human retina. Currents were passed through three electrodes simultaneously using large-scale high-density microelectrode arrays, directly evoking single spikes in retinal ganglion cells. The currents combined either linearly or nonlinearly to drive spiking, depending on the geometry of the electrodes relative to the cell. These findings were captured by a biophysical model and by a simpler parametric model in which spikes can initiate at several sites on the cell membrane and were leveraged to efficiently identify multi-electrode stimulation patterns that optimized cellular selectivity.
View details for DOI 10.1016/j.celrep.2025.116917
View details for PubMedID 41615801
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Ex vivo Model for Surgical Implantation and Functional Testing of Electronic Retinal Implants
ASSOC RESEARCH VISION OPHTHALMOLOGY INC. 2025
View details for Web of Science ID 001559100200001
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Optical mode conversion via spatiotemporally modulated atomic susceptibility
OPTICS EXPRESS
2023; 31 (1): 528-535
Abstract
Light is an excellent medium for both classical and quantum information transmission due to its speed, manipulability, and abundant degrees of freedom into which to encode information. Recently, space-division multiplexing has gained attention as a means to substantially increase the rate of information transfer by utilizing sets of infinite-dimensional propagation eigenmodes such as the Laguerre-Gaussian "donut" modes. Encoding in these high-dimensional spaces necessitates devices capable of manipulating photonic degrees of freedom with high efficiency. In this work, we demonstrate controlling the optical susceptibility of an atomic sample can be used as powerful tool for manipulating the degrees of freedom of light that pass through the sample. Utilizing this tool, we demonstrate photonic mode conversion between two Laguerre-Gaussian modes of a twisted optical cavity with high efficiency. We spatiotemporally modulate the optical susceptibility of an atomic sample that sits at the cavity waist using an auxiliary Stark-shifting beam, in effect creating a mode-coupling optic that converts modes of orbital angular momentum l = 3 → l = 0. The internal conversion efficiency saturates near unity as a function of the atom number and modulation beam intensity, finding application in topological few-body state preparation, quantum communication, and potential development as a flexible tabletop device.
View details for DOI 10.1364/OE.476638
View details for Web of Science ID 000920797200046
View details for PubMedID 36606989
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Understanding and suppressing backscatter in optical resonators
OPTICA
2022; 9 (8): 878-885
View details for DOI 10.1364/OPTICA.463723
View details for Web of Science ID 000843612600007
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Aberrated optical cavities
PHYSICAL REVIEW A
2021; 104 (1)
View details for DOI 10.1103/PhysRevA.104.013524
View details for Web of Science ID 000678776400014
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Observation of Laughlin states made of light
NATURE
2020; 582 (7810): 41-+
Abstract
Much of the richness in nature emerges because simple constituents form an endless variety of ordered states1. Whereas many such states are fully characterized by symmetries2, interacting quantum systems can exhibit topological order and are instead characterized by intricate patterns of entanglement3,4. A paradigmatic example of topological order is the Laughlin state5, which minimizes the interaction energy of charged particles in a magnetic field and underlies the fractional quantum Hall effect6. Efforts have been made to enhance our understanding of topological order by forming Laughlin states in synthetic systems of ultracold atoms7,8 or photons9-11. Nonetheless, electron gases remain the only systems in which such topological states have been definitively observed6,12-14. Here we create Laughlin-ordered photon pairs using a gas of strongly interacting, lowest-Landau-level polaritons as a photon collider. Initially uncorrelated photons enter a cavity and hybridize with atomic Rydberg excitations to form polaritons15-17, quasiparticles that here behave like electrons in the lowest Landau level owing to a synthetic magnetic field created by Floquet engineering18 a twisted cavity11,19 and by Rydberg-mediated interactions between them16,17,20,21. Polariton pairs collide and self-organize to avoid each other while conserving angular momentum. Our finite-lifetime polaritons only weakly prefer such organization. Therefore, we harness the unique tunability of Floquet polaritons to distil high-fidelity Laughlin states of photons outside the cavity. Particle-resolved measurements show that these photons avoid each other and exhibit angular momentum correlations, the hallmarks of Laughlin physics. This work provides broad prospects for the study of topological quantum light22.
View details for DOI 10.1038/s41586-020-2318-5
View details for Web of Science ID 000562462300001
View details for PubMedID 32494082
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Interacting Floquet polaritons
NATURE
2019; 571 (7766): 532-+
Abstract
Ordinarily, photons do not interact with one another. However, atoms can be used to mediate photonic interactions1,2, raising the prospect of forming synthetic materials3 and quantum information systems4-7 from photons. One promising approach combines highly excited Rydberg atoms8-12 with the enhanced light-matter coupling of an optical cavity to convert photons into strongly interacting polaritons13-15. However, quantum materials made of optical photons have not yet been realized, because the experimental challenge of coupling a suitable atomic sample with a degenerate cavity has constrained cavity polaritons to a single spatial mode that is resonant with an atomic transition. Here we use Floquet engineering16,17-the periodic modulation of a quantum system-to enable strongly interacting polaritons to access multiple spatial modes of an optical cavity. First, we show that periodically modulating an excited state of rubidium splits its spectral weight to generate new lines-beyond those that are ordinarily characteristic of the atom-separated by multiples of the modulation frequency. Second, we use this capability to simultaneously generate spectral lines that are resonant with two chosen spatial modes of a non-degenerate optical cavity, enabling what we name 'Floquet polaritons' to exist in both modes. Because both spectral lines correspond to the same Floquet-engineered atomic state, adding a single-frequency field is sufficient to couple both modes to a Rydberg excitation. We demonstrate that the resulting polaritons interact strongly in both cavity modes simultaneously. The production of Floquet polaritons provides a promising new route to the realization of ordered states of strongly correlated photons, including crystals and topological fluids, as well as quantum information technologies such as multimode photon-by-photon switching.
View details for DOI 10.1038/s41586-019-1354-5
View details for Web of Science ID 000477016700064
View details for PubMedID 31270460
https://orcid.org/0000-0003-1140-6930