Christine L Zhou

All Publications

• Synthesis of hydrazine-functionalized Polyrotaxane and formation of adaptable sliding hydrogels. MethodsX Loveland, S. J., Tong, X., Lee, H. P., Zhou, C. L., Yang, F. 2026; 16: 103970

  Abstract

  This work details the synthesis and characterization of Polyrotaxane-Hydrazine (PR-Hyd), a polyethylene glycol-based polymer utilized in the formation of Adaptable Sliding Hydrogels (ASG). ASG is a viscoelastic 3D cell culture system with reversible hydrazone bonds that can be leveraged to present cells with tunable stress relaxation and mechanical plasticity. ASG builds upon our lab's previously reported Sliding Hydrogel (SG) platform which is formed via irreversible covalent crosslinking between norbornene functionalized Polyrotaxane (PR-NB) and a dithiol crosslinker. To generate PR-Hyd, we adapted and optimized the synthesis protocol for PR-NB and used proton NMR spectroscopy to quantify polymer functionality and reduce batch-to-batch variability. In addition, this work outlines our protocol for facile ASG scaffold formation using aldehyde functionalized polyethylene glycol macromers for crosslinking. Taken together, these methods enable reproducible synthesis of PR-Hyd and the fabrication of reversibly crosslinked ASG scaffolds that can be leveraged as a 3D cell niche for applications including regenerative medicine and in vitro disease modeling.•Synthesis method for Polyrotaxane-Hydrazine, a polyethylene glycol-based polymer precursor designed for forming Adaptable Sliding Hydrogels (ASG).•Characterization of polymer functionality via proton NMR spectroscopy.•Reproducible fabrication of ASG hydrogels.

  View details for DOI 10.1016/j.mex.2026.103970

  View details for PubMedID 42233055

  View details for PubMedCentralID PMC13223800

• Evaluating the Green Solvent d-Limonene for Sustainable Chemical Delamination in Solar Panel Recycling JOURNAL OF ENERGY RESOURCES TECHNOLOGY PART A-SUSTAINABLE AND RENEWABLE ENERGY Yang, J., Burra, K., Correll-Brown, R., Zhou, C., Liu, X., Gupta, A. 2026

  View details for DOI 10.1115/1.4071511

  View details for Web of Science ID 001756676200001

• Oleo-sheets and omni-sheets: Fabric-like superabsorbers for oil, water, or any solvent CHEMICAL ENGINEERING JOURNAL Choudhary, H., Zhou, C., Raghavan, S. R. 2023; 473

  View details for DOI 10.1016/j.cej.2023.145252

  View details for Web of Science ID 001061747100001

• A better picker-upper: Superabsorbent "gel sheets"with fabric-like flexibility MATTER Choudhary, H., Zhou, C., Raghavan, S. R. 2023; 6 (2): 521-536

  View details for DOI 10.1016/j.matt.2022.11.021

  View details for Web of Science ID 001016497800001