Daniel Kwasi Amponsah

All Publications

• Racial and Ethnic Differences in Adoption of Mitral Valve Transcatheter Edge-to-Edge Repair Over a Decade in the National Veterans Affairs Healthcare System. Journal of the American Heart Association Pillai, B., Beyene, T. J., Kang, G., Amponsah, D., Heidenreich, P. A., Yong, C. M. 2024; 13 (19): e035767

  View details for DOI 10.1161/JAHA.124.035767

  View details for PubMedID 39344644

• DEI Is Not Dead: A Framework for Cardiology Fellowship Programs. Journal of the American College of Cardiology Amponsah, D., Yong, C. M. 2024; 84 (14): 1367-1371

  View details for DOI 10.1016/j.jacc.2024.07.042

  View details for PubMedID 39322330

• Artificial Intelligence to Promote Racial and Ethnic Cardiovascular Health Equity CURRENT CARDIOVASCULAR RISK REPORTS Amponsah, D., Thamman, R., Brandt, E., James, C., Spector-Bagdady, K., Yong, C. M. 2024

  View details for DOI 10.1007/s12170-024-00745-6

  View details for Web of Science ID 001294394200001

• Advancements and future perspectives in coronary angiography-derived fractional flow reserve. Progress in cardiovascular diseases Collet, C., Amponsah, D. K., Mahendiran, T., Mizukami, T., Wilgenhof, A., Fearon, W. F. 2024

  Abstract

  Angiography-derived fractional flow reserve (FFR) has emerged as a non-invasive technique to assess the functional significance of coronary artery stenoses. The clinical applications of angiography-derived FFR span a wide range of scenarios, including assessing intermediate coronary lesions and guiding revascularization decisions. This review paper aims to provide an overview of angiography-derived FFR, including its principles, clinical applications, and evidence supporting its accuracy and utility. Lastly, the review discusses future directions and ongoing research in the field, including the integration of angiography-derived FFR into routine clinical practice.

  View details for DOI 10.1016/j.pcad.2024.08.002

  View details for PubMedID 39122203

• Novel Use of Z Codes to Identify Social Determinants of Cardiovascular Disease Outcomes. Circulation Song, N., Beyene, T. J., Amponsah, D. K., Asch, S. M., Heidenreich, P. A., Yong, C. M. 2024; 150 (3): 243-245

  View details for DOI 10.1161/CIRCULATIONAHA.124.069083

  View details for PubMedID 39008558

• Sex Differences in Coronary Artery Disease Characteristics Among Patients With Type 2 Myocardial Infarction. JACC. Advances Lin, C., McCarthy, C. P., Mohebi, R., Liu, Y., Blankstein, R., Murphy, S. P., Miksenas, H., Rogers, C., Amponsah, D. K., Rambarat, P. K., Raghavan, A., Levin, A., Ghoshhajra, B., Wasfy, J. H., Hedgire, S., Januzzi, J. L. 2024; 3 (2): 100795

  Abstract

  Type 2 myocardial infarction (MI) results from coronary supply and demand imbalance and has a poor prognosis. It is crucial to identify potential sex-based differences in the prevalence and nature of coronary artery disease (CAD) within this population.The purpose of this study was to evaluate sex-based disease differences in type 2 MI among patients evaluated with coronary computed tomography angiography and fractional flow reserve.In a single-center, prospective study, patients with strictly adjudicated type 2 MI underwent coronary computed tomography angiography with fractional flow reserve.Among 50 study participants enrolled, 50% were women. A similar mix of MI precipitants was present in both sexes. ST-segment depression was more common in women (64% vs 32%), while men were more likely to have T wave inversion (68% vs 36%). Women and men had comparable coronary artery calcium scores (median: 152 [Q1, Q3: 45, 762] vs 234 [Q1, Q3: 56, 422]). Prevalence of any CAD (84% vs 100%), obstructive CAD (24% vs 28%), and hemodynamically significant focal stenosis (20% vs 32%) were similar between sexes. Total plaque volume was similar between sexes, but women had significantly lower levels of low-attenuation plaque (median: 3 [Q1, Q3: 1, 7] vs 9 [Q1, Q3: 3, 14]).Among patients with type 2 MI, prevalence of any CAD and obstructive CAD did not differ according to sex. Total plaque volume was similar between sexes, but women had a lower volume of low-attenuation plaque (DEFINing the PrEvalence and Characteristics of Coronary Artery Disease Among Patients With TYPE 2 Myocardial Infarction Using CT-FFR [DEFINE TYPE2MI]; NCT04864119).

  View details for DOI 10.1016/j.jacadv.2023.100795

  View details for PubMedID 38939381

  View details for PubMedCentralID PMC11198490

• Coronary Computed Tomographic Angiography With Fractional Flow Reserve in Patients With Type 2 Myocardial Infarction. Journal of the American College of Cardiology McCarthy, C. P., Murphy, S. P., Amponsah, D. K., Rambarat, P. K., Lin, C., Liu, Y., Mohebi, R., Levin, A., Raghavan, A., Miksenas, H., Rogers, C., Wasfy, J. H., Blankstein, R., Ghoshhajra, B., Hedgire, S., Januzzi, J. L. 2023; 82 (17): 1676-1687

  Abstract

  Type 2 myocardial infarction (T2MI) related to a supply/demand imbalance of coronary blood flow is common and associated with poor prognosis. Coronary artery disease (CAD) may predispose some individuals to T2MI and contribute to its high rate of recurrent cardiovascular events. Little is known about the presence and extent of CAD in this population.The goal of this study was to evaluate the presence and characteristics of CAD among patients with T2MI.In this prospective study, consecutive eligible individuals with Fourth Universal Definition of Myocardial Infarction criteria for T2MI were enrolled. Participants underwent coronary computed tomography angiography (CTA), fractional flow reserve derived with coronary CTA (FFRCT), and plaque volume analyses.Among 50 participants, 25 (50%) were female, and the mean age was 68.0 ± 11.4 years. Atherosclerotic risk factors were common. Coronary CTA revealed coronary plaque in 46 participants (92%). A moderate or greater stenosis (≥50%) was identified in 42% of participants, and obstructive disease (≥50% left main stenosis or ≥70% stenosis in any other epicardial coronary artery) was present in 26%. Prevalence of obstructive CAD did not differ according to T2MI cause (P = 0.54). A hemodynamically significant focal stenosis identified by FFRCT was present in 13 participants (26%). Among participants with a stenosis ≥50% (n = 21), FFRCT excluded lesion-specific hemodynamically significant stenosis in 8 cases (38%).Among individuals with adjudicated T2MI, CAD was prevalent, but the majority of patients had nonobstructive CAD. Mediators of ischemia are likely multifactorial in this population. (Defining the Prevalence and Characteristics of Coronary Artery Disease Among Patients with Type 2 Myocardial Infarction using CT-FFR [DEFINE TYPE 2 MI]; NCT04864119).

  View details for DOI 10.1016/j.jacc.2023.08.020

  View details for PubMedID 37777947

• Racial and Ethnic Differences in the Clinical Diagnosis of Aortic Stenosis. Journal of the American Heart Association Crousillat, D. R., Amponsah, D. K., Camacho, A., Kandanelly, R. R., Bapat, D., Chen, C., Selberg, A., Shaqdan, A., Tanguturi, V. K., Picard, M. H., Hung, J. W., Elmariah, S. 2022; 11 (24): e025692

  Abstract

  Background Racial and ethnic minority groups are underrepresented among patients undergoing aortic valve replacement in the United States. We evaluated the impact of race and ethnicity on the diagnosis of aortic stenosis (AS). Methods and Results In patients with transthoracic echocardiography (TTE)-confirmed AS, we assessed rates of AS diagnosis as defined by assignment of an International Classification of Diseases, Ninth Revision (ICD-9) and Tenth Revision (ICD-10) code for AS within a large multicenter electronic health record. Multivariable Cox proportional hazard and competing risk regression models were used to evaluate the 1-year rate of AS diagnosis by race and ethnicity. Among 14 800 patients with AS, the 1-year diagnosis rate for AS following TTE was 37.4%. Increasing AS severity was associated with an increased likelihood of receiving an AS diagnosis (moderate: hazard ratio [HR], 3.05 [95% CI, 2.86-3.25]; P<0.0001; severe: HR, 4.82 [95% CI, 4.41-5.28]; P<0.0001). Compared with non-Hispanic White, non-Hispanic Black (HR, 0.65 [95% CI, 0.54-0.77]; P<0.0001) and non-Hispanic Asian individuals (HR, 0.72 [95% CI, 0.57-0.90], P=0.004) were less likely to receive a diagnosis of AS. Additional factors associated with a decreased likelihood of receiving an AS diagnosis included a noncardiology TTE ordering provider (HR, 0.92 [95% CI, 0.86-0.97]; P=0.005) and TTE performed in the inpatient setting (HR, 0.72 [95% CI, 0.66-0.78]; P<0.0001). Conclusions Rates of receiving an ICD diagnostic code for AS following a diagnostic TTE are low and vary significantly by race and ethnicity and disease severity. Further studies are needed to determine if efforts to maximize the clinical recognition of TTE-confirmed AS may help to mitigate disparities in treatment.

  View details for DOI 10.1161/JAHA.122.025692

  View details for PubMedID 36533618

  View details for PubMedCentralID PMC9798798

• Racial and Ethnic Disparities in the Treatment of Aortic Stenosis: Current Challenges and Future Strategies for Achieving Equity in Care CURRENT TREATMENT OPTIONS IN CARDIOVASCULAR MEDICINE Amponsah, D. K., Crousillat, D. R., Elmariah, S. 2022; 24 (6): 109-121

  View details for DOI 10.1007/s11936-022-00963-4

  View details for Web of Science ID 000784861000001

• GLYCEMIC CONTROL IN INSULIN AND NON-INSULIN DEPENDENT DIABETIC PATIENTS WITH ST ELEVATION MYOCARDIAL INFARCTION PREDICTS TIME TO PRESENTATION Evans, J., Khachatryan, T., Hamilton, D., Stewart, A., Amponsah, D., Suh, E., Jutzy, K., Abudayyeh, I., Hilliard, A. ELSEVIER SCIENCE INC. 2017: 61

  View details for DOI 10.1016/S0735-1097(17)33450-2

  View details for Web of Science ID 000397342300062

• ISCHEMIC TIME AND RISK FACTORS ASSOCIATED WITH THE INCIDENCE OF CARDIOGENIC SHOCK IN PATIENTS PRESENTING WITH ST ELEVATION MYOCARDIAL INFARCTION Amponsah, D., Khachatryan, T., Hamilton, D., Evans, J., Stewart, A., Suh, E., Jutzy, K., Abudayyeh, I., Hilliard, A. ELSEVIER SCIENCE INC. 2017: 69

  View details for DOI 10.1016/S0735-1097(17)33458-7

  View details for Web of Science ID 000397342300070

• IMPACT OF DEMOGRAPHICS AND SOCIOECONOMIC STATUS ON MODE OF TRANSPORTATION AND TIME TO PRESENTATION IN PATIENTS WITH ST ELEVATION MYOCARDIAL INFARCTION Stewart, A., Khachatryan, T., Hamilton, D., Evans, J., Amponsah, D., Suh, E., Jutzy, K., Abudayyeh, I., Hilliard, A. ELSEVIER SCIENCE INC. 2017: 87

  View details for DOI 10.1016/S0735-1097(17)33476-9

  View details for Web of Science ID 000397342300088