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  • Analysis of neural clusters due to deep brain stimulation pulses BIOLOGICAL CYBERNETICS Kuelbs, D., Dunefsky, J., Monga, B., Moehlis, J. 2020; 114 (6): 589-607


    Deep brain stimulation (DBS) is an established method for treating pathological conditions such as Parkinson's disease, dystonia, Tourette syndrome, and essential tremor. While the precise mechanisms which underly the effectiveness of DBS are not fully understood, several theoretical studies of populations of neural oscillators stimulated by periodic pulses have suggested that this may be related to clustering, in which subpopulations of the neurons are synchronized, but the subpopulations are desynchronized with respect to each other. The details of the clustering behavior depend on the frequency and amplitude of the stimulation in a complicated way. In the present study, we investigate how the number of clusters and their stability properties, bifurcations, and basins of attraction can be understood in terms of one-dimensional maps defined on the circle. Moreover, we generalize this analysis to stimuli that consist of pulses with alternating properties, which provide additional degrees of freedom in the design of DBS stimuli. Our results illustrate how the complicated properties of clustering behavior for periodically forced neural oscillator populations can be understood in terms of a much simpler dynamical system.

    View details for DOI 10.1007/s00422-020-00850-w

    View details for Web of Science ID 000598085900003

    View details for PubMedID 33296013

    View details for PubMedCentralID 4282372