Dario Pfyffer

All Publications

• Exploring Corticospinal Functional Connectome Using Resting-State Functional Magnetic Resonance Imaging Kaptan, M., Law, C. W., Weber, K., Pfyffer, D., Zhang, X., Maronesy, T., Glover, G., Mackey, S. CHURCHILL LIVINGSTONE. 2023: 17-18

  View details for Web of Science ID 000995432100047

• Imaging Noxious Thermal Intensity Encoding Along The Neuraxis Using Simultaneous Spinal Cord-Brain Functional Magnetic Resonance Imaging Pfyffer, D., Law, C. W., Weber, K. A., Kaptan, M., Maronesy, T., Glover, G. H., Mackey, S. CHURCHILL LIVINGSTONE. 2023: 76

  View details for Web of Science ID 000995432100203

• Magnetic resonance spectroscopy investigation in the right human hippocampus following spinal cord injury. Frontiers in neurology Pfyffer, D., Zimmermann, S., Simsek, K., Kreis, R., Freund, P., Seif, M. 2023; 14: 1120227

  Abstract

  Objective: Preclinical studies have shown that cognitive impairments following spinal cord injury (SCI), such as impaired spatial memory, are linked to inflammation, neurodegeneration, and reduced neurogenesis in the right hippocampus. This cross-sectional study aims to characterize metabolic and macrostructural changes in the right hippocampus and their association to cognitive function in traumatic SCI patients.Methods: Within this cross-sectional study, cognitive function was assessed in 28 chronic traumatic SCI patients and 18 age-, sex-, and education-matched healthy controls by a visuospatial and verbal memory test. A magnetic resonance spectroscopy (MRS) and structural MRI protocol was performed in the right hippocampus of both groups to quantify metabolic concentrations and hippocampal volume, respectively. Group comparisons investigated changes between SCI patients and healthy controls and correlation analyses investigated their relationship to memory performance.Results: Memory performance was similar in SCI patients and healthy controls. The quality of the recorded MR spectra was excellent in comparison to the best-practice reports for the hippocampus. Metabolite concentrations and volume of the hippocampus measured based on MRS and MRI were not different between two groups. Memory performance in SCI patients and healthy controls was not correlated with metabolic or structural measures.Conclusion: This study suggests that the hippocampus may not be pathologically affected at a functional, metabolic, and macrostructural level in chronic SCI. This points toward the absence of significant and clinically relevant trauma-induced neurodegeneration in the hippocampus.

  View details for DOI 10.3389/fneur.2023.1120227

  View details for PubMedID 37251221

• Width of Tissue Bridges Predicts Neurologic Recovery 3 Months After Spinal Cord Injury: a Multi Center Study Pfyffer, D., Smith, A., Weber, K., Draganich, C., Berliner, J., Tefertiller, C., Hothorn, T., Schwab, J., Curt, A., Freund, P. LIPPINCOTT WILLIAMS & WILKINS. 2022

  View details for Web of Science ID 000894020500066