Electrochemical [(11)C]CO2 to [(11)C]CO conversion for PET imaging.
Chemical communications (Cambridge, England)
2017; 53 (20): 2982–85
The development of a novel electrochemical methodology to generate carbon-11 carbon monoxide ([(11)C]CO) from cyclotron-produced carbon-11 carbon dioxide ([(11)C]CO2) using Ni(cyclam) and Zn(cyclen) complexes is described. This methodology allows up to 10% yields of [(11)C]CO from [(11)C]CO2. Produced [(11)C]CO was subsequently converted to [(11)C]N-benzylbenzamide under mild conditions with a radiochemical purity (RCP) of >98%.
View details for DOI 10.1039/c7cc00319f
View details for PubMedID 28234400