Emma is a first-year PhD student in the neurosciences program. Before coming to Stanford, she worked in the laboratories of Dr. Vivian Gama and Dr. Erin Calipari at Vanderbilt University while she was an undergraduate. After graduating from Vanderbilt in May 2022 with BA in neuroscience, Emma moved to Palo Alto to start at Stanford in the summer through the ADVANCE program. Thus far, Emma has completed laboratory rotations with Dr. Jennifer Raymond and Dr. Lu Chen, and she is currently rotating with Dr. Lisa Giocomo. Her areas of interest include learning and memory, memory consolidation, and epigenetics. Outside of the lab, she is part of the leadership team for the Community College Outreach Program (CCOP). She also enjoys listening to music, spending time with friends, and dancing.
Education & Certifications
BA, Vanderbilt University, Neuroscience (2022)
Task parameters influence operant response variability in mice.
2023; 240 (1): 213-225
During operant conditioning, animals associate actions with outcomes. However, patterns and rates of operant responding change over learning, which makes it difficult to distinguish changes in learning from general changes in performance or movement. Thus, understanding how task parameters influence movement execution is essential.To understand how specific operant task parameters influenced the repetition of future operant responses, we investigated the ability of operant conditioning schedules and contingencies to promote reproducible bouts of five lever presses in mice.Mice were trained on one of the four operant tasks to test three distinct hypotheses: (1) whether a cue presented concurrently with sucrose delivery influenced the pattern of lever pressing; (2) whether requiring animals to collect earned sucrose promoted the organization of responses into bouts; and (3) whether only reinforcing bouts where interresponse time (IRT) variances were below a target promoted reproducible patterns of operant behavior.(1) Signaling reinforcer delivery with a cue increased learning rates but resulted in mice pressing the lever in fast succession until the cue turned on, rather than executing discrete bouts. (2) Requiring mice to collect the reinforcer between bouts had little effect on behavior. (3) A training strategy that directly reinforced bouts with low variance IRTs was not more effective than a traditional fixed ratio schedule at promoting reproducible action execution.Together, our findings provide insights into the parameters of behavioral training that promote reproducible actions and that should be carefully selected when designing operant conditioning experiments.
View details for DOI 10.1007/s00213-022-06298-z
View details for PubMedID 36572717