Emma Wagner
Postdoctoral Scholar, General Surgery
All Publications
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Label-free spatial profiling of the melanoma tumor microenvironment using metasurface-enhanced Raman spectroscopy.
AMER ASSOC CANCER RESEARCH. 2026
View details for DOI 10.1158/1538-7445.AM2026-697
View details for Web of Science ID 001734581500019
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Predictive Biomarkers for Immune Checkpoint Inhibitor Therapy in Advanced Melanomas.
Surgical oncology clinics of North America
2025; 34 (3): 437-451
Abstract
Biomarkers capable of predicting adverse melanoma patient responses to immune checkpoint inhibitor (ICI) therapies are an unmet need. Clinical biomarkers are largely prognostic and current response guidelines do not reflect the complex tumor-immune cell interaction dynamics attributed to ICI therapies. Validation of enhanced predictive biomarkers is dependent upon adoption of novel spatial imaging platforms capable of quantifying immune checkpoint receptor-ligand interactions within the tumor microenvironment. Assessments of these interactions at multiple points during neoadjuvant ICI regimens would inform biomarker selection based on changes in receptor-ligand interactions that best correlate with patient survival.
View details for DOI 10.1016/j.soc.2025.01.006
View details for PubMedID 40413009