Stanford Advisors

Contact

  • Academic
    ew502@stanford.edu
    University - Scholar Department: Surgery Position: Postdoctoral Scholar

Additional Info

  • Mail Code: 5148

All Publications

  • Predictive Biomarkers for Immune Checkpoint Inhibitor Therapy in Advanced Melanomas. Surgical oncology clinics of North America Wagner, E., Larijani, B., Kirane, A. R. 2025; 34 (3): 437-451

    Abstract

    Biomarkers capable of predicting adverse melanoma patient responses to immune checkpoint inhibitor (ICI) therapies are an unmet need. Clinical biomarkers are largely prognostic and current response guidelines do not reflect the complex tumor-immune cell interaction dynamics attributed to ICI therapies. Validation of enhanced predictive biomarkers is dependent upon adoption of novel spatial imaging platforms capable of quantifying immune checkpoint receptor-ligand interactions within the tumor microenvironment. Assessments of these interactions at multiple points during neoadjuvant ICI regimens would inform biomarker selection based on changes in receptor-ligand interactions that best correlate with patient survival.

    View details for DOI 10.1016/j.soc.2025.01.006

    View details for PubMedID 40413009