Bio


I come from the beautiful view also known as Chula Vista, California. I graduated from the University of California Berkeley with a B.S. in Chemistry and a minor in Biological Engineering in 2019. At Berkeley, I worked under the guidance of Dr. Gabor Somorjai working in the field of surface science. I also spent time researching in the Vision Science Program studying lipid circuits and immune response with Dr. Karsten Gronert. While at UC Berkeley, I completed a summer internship at Genentech. In the Bogyo lab, I am interested in developing covalent cyclic peptide inhibitors for future use as therapeutics, imaging agents, and biological tools.

Honors & Awards


  • Cancer Early Detection Graduate Fellowship, Alliance for Cancer Early Detection, Canary Center (2022)
  • NIH Biotechnology Graduate Fellowship, NIH Stanford Biotechnology Training Program (2021)
  • Chemical Biology Interface Fellowship, Stanford CheM-H (2019)
  • Enhancing Diversity in Graduate Education Fellowship, Stanford (2019)
  • NSF Graduate Research Fellowship, National Science Foundation (2019)

Education & Certifications


  • Bachelors of Science, UC Berkeley, Chemistry, with Minor in Biological Engineering (2019)

Current Research and Scholarly Interests


Peptide Therapeutics and Diagnostics
Phage Display
Image Guided Surgery
Cancer Imaging
Macrocycles
Covalent Probes

All Publications


  • Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows Israel Journal of Chemistry Faucher, F., Abegg, D., Ipock, P., Adibekian, A., Lovell, S., Bogyo, M. 2023

    View details for DOI 10.1002/ijch.202300020

  • Strategies for Tuning the Selectivity of Chemical Probes that Target Serine Hydrolases. Cell chemical biology Faucher, F., Bennett, J. M., Bogyo, M., Lovell, S. 2020

    Abstract

    Serine hydrolases comprise a large family of enzymes that have diverse roles in key cellular processes, such as lipid metabolism, cell signaling, and regulation of post-translation modifications of proteins. They are also therapeutic targets for multiple human pathologies, including viral infection, diabetes, hypertension, and Alzheimer disease; however, few have well-defined substrates and biological functions. Activity-based probes (ABPs) have been used as effective tools to both profile activity and screen for selective inhibitors of serine hydrolases. One broad-spectrum ABP containing a fluorophosphonate electrophile has been used extensively to advance our understanding of diverse serine hydrolases. Due to the success of this single reagent, several robust chemistries have been developed to further diversify and tune the selectivity of ABPs used to target serine hydrolases. In this review, we highlight approaches to identify selective serine hydrolase ABPs and suggest new synthetic methodologies that could be applied to further advance probe development.

    View details for DOI 10.1016/j.chembiol.2020.07.008

    View details for PubMedID 32726586

  • Supported iron catalysts for Michael addition reactions MOLECULAR CATALYSIS Ye, R., Faucher, F. F., Somorjai, G. A. 2018; 447: 65-71
  • New Insights into Aldol Reactions of Methyl Isocyanoacetate Catalyzed by Heterogenized Homogeneous Catalysts NANO LETTERS Ye, R., Zhao, J., Yuan, B., Liu, W., De Araujo, J., Faucher, F. F., Chang, M., Deraedt, C. V., Toste, F., Somorjai, G. A. 2017; 17 (1): 584-589

    Abstract

    The Hayashi-Ito aldol reaction of methyl isocyanoacetate (MI) and benzaldehydes, a classic homogeneous Au(I)-catalyzed reaction, was studied with heterogenized homogeneous catalysts. Among dendrimer encapsulated nanoparticles (NPs) of Au, Pd, Rh, or Pt loaded in mesoporous supports and the homogeneous analogues, the Au NPs led to the highest yield and highest diastereoselectivity of products in toluene at room temperature. The Au catalyst was stable and was recycled for at least six runs without substantial deactivation. Moreover, larger pore sizes of the support and the use of a hydrophobic solvent led to a high selectivity for the trans diastereomer of the product. The activation energy is sensitive to neither the size of Au NPs nor the support. A linear Hammett plot was obtained with a positive slope, suggesting an increased electron density on the carbonyl carbon atom in the rate-limiting step. IR studies revealed a strong interaction between MI and the gold catalyst, supporting the proposed mechanism, in which rate-limiting step involves an electrophilic attack of the aldehyde on the enolate formed from the deprotonated MI.

    View details for DOI 10.1021/acs.nanolett.6b04827

    View details for Web of Science ID 000392036600082

    View details for PubMedID 27966991