Gabrielle Barsh

All Publications

• Can electronic medical records predict neonatal seizures? The Lancet. Digital health Barsh, G. R., Wusthoff, C. J. 2023; 5 (4): e175-e176

  View details for DOI 10.1016/S2589-7500(23)00041-9

  View details for PubMedID 36963906

• Can electronic medical records predict neonatal seizures? LANCET DIGITAL HEALTH Barsh, G. R., Wusthoff, C. J. 2023; 5 (4): E175-E176

  View details for Web of Science ID 000995066100001

• Episodic ataxic gait in a healthy toddler: an exemplary case of recurrent vertigo of childhood. The Journal of pediatrics Silverman, A., Barsh, G. R., Jeng, S. 2022

  View details for DOI 10.1016/j.jpeds.2022.12.015

  View details for PubMedID 36549413

• Retinoic Acid Organizes the Zebrafish Vagus Motor Topographic Map via Spatiotemporal Coordination of Hgf/Met Signaling. Developmental cell Isabella, A. J., Barsh, G. R., Stonick, J. A., Dubrulle, J., Moens, C. B. 2020; 53 (3): 344-357.e5

  Abstract

  Information flow through neural circuits often requires their organization into topographic maps in which the positions of cell bodies and synaptic targets correspond. To understand how topographic map development is controlled, we examine the mechanism underlying targeting of vagus motor axons to the pharyngeal arches in zebrafish. We reveal that retinoic acid organizes topography by specifying anterior-posterior identity in vagus motor neurons. We then show that chemoattractant signaling between Hgf and Met is required for vagus innervation of the pharyngeal arches. Finally, we find that retinoic acid controls the spatiotemporal dynamics of Hgf/Met signaling to coordinate axon targeting with the developmental progression of the pharyngeal arches and show that experimentally altering the timing of Hgf/Met signaling is sufficient to redirect axon targeting and disrupt the topographic map. These findings establish a mechanism of topographic map development in which the regulation of chemoattractant signaling in space and time guides axon targeting.

  View details for DOI 10.1016/j.devcel.2020.03.017

  View details for PubMedID 32302545

  View details for PubMedCentralID PMC7237105

• COVID-19 and Kawasaki Disease: Novel Virus and Novel Case. Hospital pediatrics Jones, V. G., Mills, M. n., Suarez, D. n., Hogan, C. A., Yeh, D. n., Bradley Segal, J. n., Nguyen, E. L., Barsh, G. R., Maskatia, S. n., Mathew, R. n. 2020

  View details for DOI 10.1542/hpeds.2020-0123

  View details for PubMedID 32265235

• Vagus Motor Neuron Topographic Map Determined by Parallel Mechanisms of hox5 Expression and Time of Axon Initiation. Current biology : CB Barsh, G. R., Isabella, A. J., Moens, C. B. 2017; 27 (24): 3812-3825.e3

  Abstract

  Many networks throughout the nervous system are organized into topographic maps, where the positions of neuron cell bodies in the projecting field correspond with the positions of their axons in the target field. Previous studies of topographic map development show evidence for spatial patterning mechanisms, in which molecular determinants expressed across the projecting and target fields are matched directly in a point-to-point mapping process. Here, we describe a novel temporal mechanism of topographic map formation that depends on spatially regulated differences in the timing of axon outgrowth and functions in parallel with spatial point-to-point mapping mechanisms. We focus on the vagus motor neurons, which are topographically arranged in both mammals and fish. We show that cell position along the anterior-posterior axis of hindbrain rhombomere 8 determines expression of hox5 genes, which are expressed in posterior, but not anterior, vagus motor neurons. Using live imaging and transplantation in zebrafish embryos, we additionally reveal that axon initiation is delayed in posterior vagus motor neurons independent of neuron birth time. We show that hox5 expression directs topographic mapping without affecting time of axon outgrowth and that time of axon outgrowth directs topographic mapping without affecting hox5 expression. The vagus motor neuron topographic map is therefore determined by two mechanisms that act in parallel: a hox5-dependent spatial mechanism akin to classic mechanisms of topographic map formation and a novel axon outgrowth-dependent temporal mechanism in which time of axon formation is spatially regulated to direct axon targeting.

  View details for DOI 10.1016/j.cub.2017.11.022

  View details for PubMedID 29225029

  View details for PubMedCentralID PMC5755714

• Leucine-rich repeat transmembrane proteins instruct discrete dendrite targeting in an olfactory map NATURE NEUROSCIENCE Hong, W., Zhu, H., Potter, C. J., Barsh, G., Kurusu, M., Zinn, K., Luo, L. 2009; 12 (12): 1542-U89

  Abstract

  Olfactory systems utilize discrete neural pathways to process and integrate odorant information. In Drosophila, axons of first-order olfactory receptor neurons (ORNs) and dendrites of second-order projection neurons (PNs) form class-specific synaptic connections at approximately 50 glomeruli. The mechanisms underlying PN dendrite targeting to distinct glomeruli in a three-dimensional discrete neural map are unclear. We found that the leucine-rich repeat (LRR) transmembrane protein Capricious (Caps) was differentially expressed in different classes of PNs. Loss-of-function and gain-of-function studies indicated that Caps instructs the segregation of Caps-positive and Caps-negative PN dendrites to discrete glomerular targets. Moreover, Caps-mediated PN dendrite targeting was independent of presynaptic ORNs and did not involve homophilic interactions. The closely related protein Tartan was partially redundant with Caps. These LRR proteins are probably part of a combinatorial cell-surface code that instructs discrete olfactory map formation.

  View details for DOI 10.1038/nn.2442

  View details for Web of Science ID 000272065600014

  View details for PubMedID 19915565

  View details for PubMedCentralID PMC2826190