Contact

  • Academic
    grbarsh@stanford.edu
    University - Other Teaching/Research Department: Pediatric Neurology Position: Instructor

Additional Info

  • Mail Code: 5784

All Publications

  • COVID-19 and Kawasaki Disease: Novel Virus and Novel Case. Hospital pediatrics Jones, V. G., Mills, M. n., Suarez, D. n., Hogan, C. A., Yeh, D. n., Bradley Segal, J. n., Nguyen, E. L., Barsh, G. R., Maskatia, S. n., Mathew, R. n. 2020

    View details for DOI 10.1542/hpeds.2020-0123

    View details for PubMedID 32265235

  • Leucine-rich repeat transmembrane proteins instruct discrete dendrite targeting in an olfactory map NATURE NEUROSCIENCE Hong, W., Zhu, H., Potter, C. J., Barsh, G., Kurusu, M., Zinn, K., Luo, L. 2009; 12 (12): 1542-U89

    Abstract

    Olfactory systems utilize discrete neural pathways to process and integrate odorant information. In Drosophila, axons of first-order olfactory receptor neurons (ORNs) and dendrites of second-order projection neurons (PNs) form class-specific synaptic connections at approximately 50 glomeruli. The mechanisms underlying PN dendrite targeting to distinct glomeruli in a three-dimensional discrete neural map are unclear. We found that the leucine-rich repeat (LRR) transmembrane protein Capricious (Caps) was differentially expressed in different classes of PNs. Loss-of-function and gain-of-function studies indicated that Caps instructs the segregation of Caps-positive and Caps-negative PN dendrites to discrete glomerular targets. Moreover, Caps-mediated PN dendrite targeting was independent of presynaptic ORNs and did not involve homophilic interactions. The closely related protein Tartan was partially redundant with Caps. These LRR proteins are probably part of a combinatorial cell-surface code that instructs discrete olfactory map formation.

    View details for DOI 10.1038/nn.2442

    View details for Web of Science ID 000272065600014

    View details for PubMedID 19915565

    View details for PubMedCentralID PMC2826190