Instructor, Neurology & Neurological Sciences
Board Certification: American Board of Psychiatry and Neurology, Neurology (2021)
Residency: Stanford University Dept of Neurology (2021) CA
Internship: Stanford University Internal Medicine Residency (2018) CA
Medical Education: University of Texas Southwestern Medical School (2017) TX
Atypical abnormal eye movements in PNPO-related epilepsy
LIPPINCOTT WILLIAMS & WILKINS. 2020
View details for Web of Science ID 000536058002073
Identification of a motor-to-auditory pathway important for vocal learning.
Learning to vocalize depends on the ability to adaptively modify the temporal and spectral features of vocal elements. Neurons that convey motor-related signals to the auditory system are theorized to facilitate vocal learning, but the identity and function of such neurons remain unknown. Here we identify a previously unknown neuron type in the songbird brain that transmits vocal motor signals to the auditory cortex. Genetically ablating these neurons in juveniles disrupted their ability to imitate features of an adult tutor's song. Ablating these neurons in adults had little effect on previously learned songs but interfered with their ability to adaptively modify the duration of vocal elements and largely prevented the degradation of songs' temporal features that is normally caused by deafening. These findings identify a motor to auditory circuit essential to vocal imitation and to the adaptive modification of vocal timing.
View details for DOI 10.1038/nn.4563
View details for PubMedID 28504672