Howard Chiu

All Publications

• Neonatal brain-age models in full- and preterm infants. bioRxiv : the preprint server for biology Chiu, H., Richie-Halford, A. C., Lazarus, M. F., Rokem, A., Poblaciones, R. V., Marchman, V. A., Travis, K. E., Scala, M. L., Feldman, H. M., Yeatman, J. D. 2026

  Abstract

  Prematurity affects brain development and increases risk for neurodevelopmental impairments. Yet reliable biomarkers for at-risk infants remain limited. The goals of this study are (1a) to construct a white matter neonatal brain-age model including full-term and preterm neonates from a large publicly-available data set, (1b) to evaluate the accuracy of this model for characterizing the preterm brain from the same data set; (2) to determine if a similar model can predict brain-age based on clinical MRI scans from high-risk neonates born preterm; and (3) to evaluate whether this predictive model provides information about the infant's health beyond conventional clinical and demographic measures. We developed brain-age prediction models using diffusion magnetic resonance imaging-derived white matter features from two datasets: (1) the developing Human Connectome Project (dHCP; 368 healthy infants) and (2) a clinical sample collected at the Lucile Packard Children's Hospital (LPCH; 162 high-risk preterm infants). White matter features demonstrated strong predictive performance in the dHCP dataset (within 3.9 days) and the LPCH clinical dataset (within 6.6 days). However, brain-age metrics (i.e., brain-age gap) showed no significant associations with health complications measured by a composite score of common prematurity complications. While tractometry-derived brain-age models accurately characterize brain maturation in the neonatal brain, their sensitivity to clinical complications in preterm infants appears limited. Global white matter maturation measures derived from clinical grade data may be insufficiently sensitive to capture the cumulative burden of prematurity-related morbidities, suggesting need for multimodal or longitudinal biomarkers.

  View details for DOI 10.64898/2026.01.23.701337

  View details for PubMedID 41648111

  View details for PubMedCentralID PMC12871679

• Estimating the Replicability of Psychology Experiments After an Initial Failure to Replicate COLLABRA-PSYCHOLOGY Boyce, V., Prystawski, B., Abutto, A. B., Chen, E. M., Chen, Z., Chiu, H., Ergin, I., Gupta, A., Hu, C., Kemmann, B., Klevak, N., Lua, V. Y. Q., Mazzaferro, M. M., Mon, K., Ogunbamowo, D., Pereira, A., Troutman, J., Tung, S., Uricher, R., Frank, M. C. 2024; 10 (1)

  View details for DOI 10.1525/collabra.125685

  View details for Web of Science ID 001369676400001

• Prefrontal and frontostriatal structures mediate academic outcomes associated with ADHD symptoms Brain Disorders Chiu, H., et al 2021

  View details for DOI 10.1016/j.dscb.2021.100023